Science Behind Zerona

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ZERONA® Science Behind Body Slimming

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History of Low-Level Laser Therapy (LLLT) Used worldwide for over 40 years with no negative side effects A significant body of peer-reviewed published research has illustrated low-level laser therapy’s ability to modulate cell bioenergetics, consequentially influencing numerous intracellular biochemical pathways, culminating as an observable clinical outcome. (635nm) ZERONA is a low-level laser therapy (3LT™). Laser therapy is used across a myriad of neurologic, dental, ophthalmic, dermatologic disorders and injuries. Applications of 3LT™ are diverse and potentially limitless. ZERONA emits a “cold output” producing no thermal effect on the body’s tissue. ZERONA helps the body absorb fat by stimulating biological function. Intracellular response To laser therapy

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The Zerona device employs 5 independent laser diodes The wavelength utilized falls within the visible spectrum at 635nm The intensity is 17.5 mW per diode, categorizing the laser as a class IIIb. The device emits a patented line-generated beam, which allows the Zerona to deliver a high concentration of photons across a large surface area. ZERONA® BASICS

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Real science behind ZERONA body slimming ZERONA The FIRST Aesthetic Laser with double blinded, placebo controlled, randomized, multi-site, peer reviewed clinical studies that provide statistically relevant clinical evidence for circumferential reduction. “90% of devices at the FDA do not have clinical data to back their claims… Of the 10% that do have clinical studies, almost all are not randomized double-blind, placebo controlled, multi-site .” ~ Heather Rosecrans, Director, 510k staff, Office of Device Evaluation, CDRH

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Efficacy standards of placebo-controlled, double-blind, randomized, multi site study set by FDA Sixty-seven subjects were enrolled 35 test participants 32 control participants Patients were not allowed to change their diet or lifestyle in any way, including increased fluid intake, use of supplements, or an increase in exercise. Patient’s waist, hip, and thighs were treated simultaneously. Patients were treated consecutively for two weeks, every-other-day (MWF), for a total of 6 treatments. Real science behind ZERONA body slimming PHASE 1 MEDICAL DEVICE CLINICAL TRIAL

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Mean change in total combined circumference from the waist, hips, and thighs. This outcome exceeded the pre-established target of 35% difference between treatment groups by 22%. The odds are 1 in 100,000 that these results were due to random chance. Statistically Significant (t = -7.30; df = 65; p<0.0001). PHASE 1 MEDICAL DEVICE CLINICAL TRIAL Real science behind ZERONA body slimming

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0 Minute 1 Minute 6 Minutes 12 Minutes 18 Minutes Filled Adipose Cell Emulsified Fatty Debris Outside Cell Empty & Collapsed Adipose Cell Real science behind ZERONA body slimming

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Transitory Pore Forming Emulsified Fatty Debris leaking out of Cell Empty & Collapsed Adipose Cell Real science behind ZERONA body slimming

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When 1,000’s of Adipose cells are emptied of their fatty debris the slimming effect occurs. Panel of Collapsed and emptied Adipose Cells Real science behind ZERONA body slimming

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How Does the Fatty Debris Leave the Body? The fat leaves the cell and enters into the interstitial space. The fatty material is absorbed by the lymphatic system Transported via afferent lymph vessels to lymph nodes Triglycerides are broken down via lipases (Lysosomal Acid Lipase) Transported to the circulatory system where the debris can be processed by the liver (fatty acid oxidation). Overall, the body has a natural system in place to transport and degrade triglycerides without inducing an adverse outcome. Real science behind body slimming Several studies were completed on Lipid panels to determine that Triglyceride and Cholesterol levels did not increase.

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CurvaTM, a supplement formulated specifically for ZERONA to help enhance the body’s natural pathways used to transport and breakdown the fat. Active Ingredients 200mg Niacin 200mg Green Tea Extract 100 mg L-carnitine 60 mg Ginkgo Biloba 880 mg of Omega 3 and Omega 6 fatty acids BODY SLIMMING PROTOCOL – Enhancing Results ZERONA has been PROVEN EFFECTIVE as a standalone device. However, by making simple lifestyle changes patients can enhance their results.

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