Endocrinology of Pancreas: Endocrinology of Pancreas Dr.Zafar
Islets of Langerhans: Islets of Langerhans A cells B cells D cells F cells
Insulin : Insulin Polypeptide of 51 amino acids A lpha chain (21 amino acids) Beta chain(30 amino acids)
Synthesis: Synthesis Site RER
Metabolism: Metabolism Binding of insulin to it’s receptors Receptors are present in the liver and kidney Insulin protease(IDE)
Mode of action: Mode of action H-R complex Autophosphorylation of tyrosine kinase Activation/inactivation of intracellular enzyme
Regulation of secretion: Regulation of secretion Normal blood glucose (80-100mg/ dL ) Normal insulin secretion(10µU/minute) Biphasic After meal (100µU/minute) After 15 minutes
PowerPoint Presentation: Role of proteins Arginine Lysine Role of lipid derivatives Beta ketoacids Role of GIT hormones Gastrin, CCK,Secretin Role of endocrine glands Growth hormone,cortisol ANS PNS stimulate SNS stimulate
Actions : Actions Increase in the uptake of glucose by the cells Liver,muscle,adipose tissues Increase in the number of GLUT-4 Renal tubules brain, wall of intestine,RBC’s Promotes peripheral utilization of glucose Promotes storage of glucose Inhibition of glycogenolysis Inhibition of gluconeogensis
Protein metabolism: Protein metabolism Increase in the uptake of amino acids Increase in t synthesis of proteins Prevents catabolism of proteins by decreasing activity of enzymes Prevents conversion of protein to glucose
Fat metabolism: Fat metabolism Transport of fatty acids into adipose tissues Prevents catabolism of fats by decreasing activity of enzymes Synthesis of fatty acids and triglycerides
Growth : Growth Anabolic
Signs &symptoms : Signs &symptoms Glucosouria Osmotic diursis Polyuria Polydipsia Polyphagia Asthenia Acidosis Acetone breathing, circulatory shock
PowerPoint Presentation: Wo jis ka aik hi beta ho , bhoka 8 pehroon sey Batao ! Ehl_e_danish,,wo gandum ley ? Ya takhti ley