Endocrinology of Pancreas

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Endocrinology of Pancreas:

Endocrinology of Pancreas Dr.Zafar

Islets of Langerhans:

Islets of Langerhans A cells B cells D cells F cells

Insulin :

Insulin Polypeptide of 51 amino acids A lpha chain (21 amino acids) Beta chain(30 amino acids)

Synthesis:

Synthesis Site RER

Metabolism:

Metabolism Binding of insulin to it’s receptors Receptors are present in the liver and kidney Insulin protease(IDE)

Mode of action:

Mode of action H-R complex Autophosphorylation of tyrosine kinase Activation/inactivation of intracellular enzyme

Regulation of secretion:

Regulation of secretion Normal blood glucose (80-100mg/ dL ) Normal insulin secretion(10µU/minute) Biphasic After meal (100µU/minute) After 15 minutes

PowerPoint Presentation:

Role of proteins Arginine Lysine Role of lipid derivatives Beta ketoacids Role of GIT hormones Gastrin, CCK,Secretin Role of endocrine glands Growth hormone,cortisol ANS PNS stimulate SNS stimulate

Actions :

Actions Increase in the uptake of glucose by the cells Liver,muscle,adipose tissues Increase in the number of GLUT-4 Renal tubules brain, wall of intestine,RBC’s Promotes peripheral utilization of glucose Promotes storage of glucose Inhibition of glycogenolysis Inhibition of gluconeogensis

Protein metabolism:

Protein metabolism Increase in the uptake of amino acids Increase in t synthesis of proteins Prevents catabolism of proteins by decreasing activity of enzymes Prevents conversion of protein to glucose

Fat metabolism:

Fat metabolism Transport of fatty acids into adipose tissues Prevents catabolism of fats by decreasing activity of enzymes Synthesis of fatty acids and triglycerides

Growth :

Growth Anabolic

Signs &symptoms :

Signs &symptoms Glucosouria Osmotic diursis Polyuria Polydipsia Polyphagia Asthenia Acidosis Acetone breathing, circulatory shock

PowerPoint Presentation:

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