stemcells

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Presented by T.SHIVAKUMAR [email protected] KOTTAM INSTITUTE OF PHARMACY STEM CELLS

DEFINITION:

DEFINITION Stem cells are the generic cells which are a class of undifferentiated cells that are able to differentiated into specialized cell

SOURCES:

SOURCES THE MAJOR SOURCES OF STEMCELLS ARE Embryos Adult tissues/organs Umbilical cords Cadavers (survival of neural progenitor cells from human post-mortem tissues up to 20hr after death)

TYPES:

TYPES BASED ON THE TYPE OF ORIGIN AND POTENCY EMBRYONIC STEM CELLS ADULT STEM CELLS

PROPERTIES:

PROPERTIES Self-renewal The ability to go through numerous cycles cell division by maintaining undifferentiated state Potency The capacity to differentiate into specialized cell types

Self-renewal:

Self-renewal Two mechanisms are involved Obligatory asymmetric replication Stochastic differentiation

POTENCY:

POTENCY Potential classification includes Totipotent: Ex : zygote Pluripotent: Ex : embryonic stem cells Multipotent: Ex: hematopoietic stem cells(RBC&WBC) Oligopotent: Ex: lymphoid/myeloid stem cells Unipotent: Ex: muscle stem cells

IDENTIFICATION:

IDENTIFICATION Examining chromosomes under microscope Presence of surface markers 1.Transcription factors like proteins oct-4,nanog,sox-2 2.Cellsurface antigens- glycolipids,keratan sulfate antigen

STEM CULTURES:

STEM CULTURES

TREATMENTS:

TREATMENTS

THERAPIES:

THERAPIES ADULT STEMCELL TRANSPLANT BONE MARROW STEM CELLS ADULT STEMCELL TRANSPLANT PERIPHERAL BLOOD STEM CELLS UMBILICAL CORD BLOOD STEM CELL TRANSPLANT

PowerPoint Presentation:

Umbilical Cord Blood Stem Cell Transplant BONE MARROW STEM CELLS STEM CELL TRANSPLANTS

CAN THESE STEM CELLS CURE HEART DISEASES?:

CAN THESE STEM CELLS CURE HEART DISEASES? Rodent Model of Myocardial Infarction

Heart Muscle Repair with Adult Stem Cells :

Heart Muscle Repair with Adult Stem Cells

CONCLUSION:

CONCLUSION Now days these stem cells are effectively used in the treatment of heart diseases & addressing the nations leading causes of death .

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THANK YOU

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