A RARE CASE OF GARLIC INDUCED HYPERSENSITIVITY REACTION

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Aim of the study: The objective of present study is to report a rare Case of contact dermatitis that was seen in 30 years old female from Narasaraopet of Guntur district, South India. Place of study: This case was studied in the outpatient department of Dermatology, Guntur City Hospital, Guntur. Period of Study: This case was studied and investigated in detail in the month of May 2014 in the above hospital. Case Report: A young female aged 30years came with past history of Hyperthyroidism for the past 11months and Obese. She needed support to have food. On examination she had Hoarse throat, Body pains Irregular periods .along with this on application of Raw Garlic for pimples turned into Contact Dermatitis. This study was compared and well correlated with available literature. Conclusion: Since this is a rare case of Garlic Induced Hypersensitivity reaction made us interesting to study.

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104 | P a g e International Standard Serial Number ISSN: 2319-8141 Full Text Available On www.ijupbs.com International Journal of Universal Pharmacy and Bio Sciences 34: July-August 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES IMPACT FACTOR 1.89 ICV 5.13 Bio Sciences CASE REPORT …… A RARE CASE OF GARLIC INDUCED HYPERSENSITIVITY REACTION Dr. D. Naga SatishBabu K. Mallikarjun Reddy G. Raghavendra Kumar D. Narasimharao Dr. J. N. Suresh Kumar T. Swarupa Rani Department of Pharmacy practice Narasaraopet Institute of Pharmaceutical Sciences Narasaraopet Guntur D.t A.P. KEYWORDS: Contact Dermatitis Hypersensitivity Hypothyroidism Garlic. For Correspondence: Dr. D.Naga Satish Babu Address: Department of Pharmacy practice Narasaraopet Institute of Pharmaceutical Sciences Narasaraopet Guntur D.t A.P. Email ID: babusatish1437gmail.c om ABSTRACT Aim of the study: The objective of present study is to report a rare Case of contact dermatitis that was seen in 30 years old female from Narasaraopet of Guntur district South India. Place of study: This case was studied in the outpatient department of Dermatology Guntur City Hospital Guntur. Period of Study: This case was studied and investigated in detail in the month of May 2014 in the above hospital. Case Report: A young female aged 30years came with past history of Hyperthyroidism for the past 11months and Obese. She needed support to have food. On examination she had Hoarse throat Body pains Irregular periods .along with this on application of Raw Garlic for pimples turned into Contact Dermatitis. This study was compared and well correlated with available literature. Conclusion: Since this is a rare case of Garlic Induced Hypersensitivity reaction made us interesting to study.

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105 | P a g e International Standard Serial Number ISSN: 2319-8141 Full Text Available On www.ijupbs.com INTRODUCTION: Food allergies occur when the immune system identifies the proteins in a particular food as harmful to the body subsequently reacting to try to "fight off" the "harmful" proteins which are in fact harmless. Garlic allergies are not very common but are especially inconvenient to chefs who have to handle garlic on a regular basis. Allergic reactions dont occur only when you consume a food allergen but may also occur when you handle it or even breathe in particles of it. Some symptoms of a garlic allergy include:  Itching or swelling of the mouth tongue or lips  Skin reactions eczema contact dermatitis hives swelling and redness of the extremities or face  Gastrointestinal symptoms abdominal pain nausea vomiting diarrhea  Respiratory symptoms runny or stuffy nose coughing sneezing wheezing difficulty breathing  Cardiovascular symptoms drop in blood pressure lightheadedness fainting If you experience symptoms of anaphylaxis which include nausea vomiting weak or rapid pulse difficulty breathing confusion and loss of consciousness seek immediate medical attention as this can be fatal. Anaphylaxis is a fairly rare reaction to a garlic allergy but has been known to happen. If you have a severe allergy to garlic you may need to carry epinephrine with you so you can treat yourself in case you come into contact with garlic at any point. Garlic is usually a trouble-free herb providing more benefits than complication but thats not always the case. Prolonged contact with garlic may cause irritation to the skin or even lesions. Garlic has very little toxicity and garlic allergies are rare occurrences compared with other foods. Even so it does happen and sometimes with very serious effects. Cooked Versus Raw Garlic 2 The enzyme in garlic responsible for allergic reactions is also responsible for its healthiest benefits. The Linus Pauling Institute at Oregon State University reports that the enzyme produces the chemical compound allicin which breaks down into other important compounds some of which may be effective for fighting cancer. If you want the benefits of garlic without the risk crush it let it sit for 10 minutes and cook it. By letting it sit for a while you allow time for the enzyme to produce allicin. Cooking it eliminates the enzymatic activity and most if not all of the risk of an allergic reaction. What doesnt get eliminated are most of the healthy benefits of garlic.

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106 | P a g e International Standard Serial Number ISSN: 2319-8141 Full Text Available On www.ijupbs.com Photo: 1 Photo: 2 Case Reports: A young female aged 30years came with past history of Hyperthyroidism for the past 11months. She needed support to have food. On examination she had Hoarse throat Body pains Irregular periods .along with this on application of Raw Garlic for pimples turned into Red colored patches on skin. Past History: past history of Hyperthyroidism for the past 11months. She needed support to have food. No past history of weight loss evening rise of temperature. Family History: There was no family history of hyperthyroidism diabetes but her mother has hypothyroidism On Examination: she was moderately built and under nourished. She had no cyanosis Clubbing neither jaundice nor lymphadenopathy. But Red colored patches on Skin observed. No history of trauma radiation exposure. All the other systems like respiratory system cardiovascular systems were normal and abdomen was soft and no mass felt. All his other parameters were normal. Investigations: Hormonal Assay shows TSH LEVEL 0.60 Micro/ML which shows abnormal. Skin prick tests and specific IgE immunoassay with several pollens and foods were performed as well as the prick-prick test with young garlic and SDS-PAGE followed by immunoblotting IgE to young garlic and other Liliaceae species mustard sesame parsley celery hazelnut almond and pollen of birch and mugwort. Conclusion: Garlic is well known to cause contact dermatitis and asthma. However it is a very rare cause of skin allergyWe describe IgE-mediated reaction to young garlic in patient sensitized to pollen and dried fruit. Take Home Message: Garlic induced anaphylactic reaction is a rare condition how ever be careful while applying Garlic for pimples for a persons with other co morbid conditions

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107 | P a g e International Standard Serial Number ISSN: 2319-8141 Full Text Available On www.ijupbs.com REFERENCES: 1. http://www.livestrong.com/article/524637-raw-garlic-allergies. 2. http://www. health.howstuffworks.com 3. Anaphylactic reaction to young garlic.Pérez-Pimiento AJ PMID:10435479 PubMed – indexed for MEDLINE

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