Biosynthesis of Amino Acids

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BIOCHEMISTRY

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Biosynthesis of Amino Acids:

Biosynthesis of Amino Acids M.Prasad Naidu MSc Medical Biochemistry, Ph.D,.

Overview:

Overview

Overview (cont):

Overview (cont)

Biosynthetic Families:

Biosynthetic Families Metabolic Precursors Amino Acids a -ketoglutarate Glutamate Glutamine Proline Arginine 3-Phophoglycerate Serine Glycine Cysteine

Biosynthetic Families (cont):

Biosynthetic Families (cont) Metabolic Precursors Amino Acids Oxaloacetate Aspartate, Asparagine Methionine, Threonine, Lysine Pyruvate Alanine, Valine, Leucine Isoleucine

Biosynthetic Families (cont):

Biosynthetic Families (cont) Metabolic Precursors Amino Acids Phosphoenolpyruvate Tryptophan and erythrose 4-phosphate Phenlyalanine Tyrosine Ribose 5-phophate Histidine

a-Ketoglutarate Family:

a- Ketoglutarate Family

a-Ketoglutamate to glutamate/glutamine:

a -Ketoglutamate to glutamate/glutamine Glutamate + NH 4 + + ATP Glutamine synthetase Glutamine + ADP + Pi + H + a -Ketoglutamate + glutamine + NADPH + H + Glutamate synthase 2 glutamate + NADP +

a-Ketoglutamate to glutamate/glutamine:

a -Ketoglutamate to glutamate/glutamine Net Reaction: a -Ketoglutarate + NH 4 + + NADPH + ATP L-glutamate + NADP + + ADP + Pi

a-Ketoglutarate Family:

a- Ketoglutarate Family

Synthesis of Proline:

Synthesis of Proline

Synthesis of Proline:

Synthesis of Proline

Synthesis of Arginine:

Synthesis of Arginine

Synthesis of Arginine:

Synthesis of Arginine

3-Phosphoglycerate Family:

3-Phosphoglycerate Family

Synthesis of Serine and Glycine:

Synthesis of Serine and Glycine

Synthesis of Cysteine:

Synthesis of Cysteine

Oxoloacetate Family:

Oxoloacetate Family

Synthesis of Aspartate and Asparagine:

Synthesis of Aspartate and Asparagine Oxaloacetate Aspartate Transamination from glutamate Amidation with Glutamine donating NH 4 + Asparagine

Synthesis of Lysine, Methionine, and Threonine:

Synthesis of Lysine, Methionine, and Threonine See handout

Pyruvate Family:

Pyruvate Family

Synthesis of Alanine:

Synthesis of Alanine Pyruvate Alanine Transamination from glutamate

Synthesis of Isoleucine, Valine,and Leucine:

Synthesis of Isoleucine, Valine,and Leucine See handout

Phosphoenolpyruvate and erythrose 4-phosphate Family:

Phosphoenolpyruvate and erythrose 4-phosphate Family

Synthesis of Chorismate:

Synthesis of Chorismate

Synthesis of Tryptophan:

Synthesis of Tryptophan

Synthesis of Tyrosine and Phenylalanine:

Synthesis of Tyrosine and Phenylalanine

Synthesis of Tyrosine and Phenylalanine (cont):

Synthesis of Tyrosine and Phenylalanine (cont)

Biosynthesis of Histidine:

Biosynthesis of Histidine See handout

Possible Test Questions:

Possible Test Questions Provide the 6 metabolic precursors and the amino acids which they lead to. Duplicate the Amino Acid Synthesis Overview Flow Chart. Expand the sections need to show the synthesis of Glutamate, Glutamine, Proline, Arginine, Serine, Cysteine, Glycine, and starting from Chorismate Tryptophan, Tyrosine and Phenylalanine. (40 points!!)

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