Gene Regulation -Blackboard

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Slide 1:

MUTATION AND GENE REGULATION

Gene Mutation:

Gene Mutation Point mutation – one or more nucleotides are changed in the DNA sequence substitution insertion deletion Frameshift Mutation

Gene Mutation:

Gene Mutation

Gene Mutation:

Gene Mutation

Chromosome Mutations:

Chromosome Mutations involves changes in the structure of a chromosome Deletion Duplication Inversion Translocation

Chromosome Mutation:

Chromosome Mutation

Gene Expression:

Gene Expression Only a fraction of genes are expressed at a given time Genes can be turned on and off

Prokaryotic Gene Regulation:

Prokaryotic Gene Regulation Operon – a group of genes that acts together

Prokaryotic Gene Regulation:

Prokaryotic Gene Regulation In E. Coli , a lac operon controls the breakdown of lactose into glucose and galactose

Prokaryotic Gene Regulation:

Prokaryotic Gene Regulation Lac genes are turned off when repressors bind to operator sites Lac genes are turned on when lactose is present

Animation:

Lac Operon Animation

Eukaryotic Gene Regulation:

Eukaryotic Gene Regulation Most eukaryotic genes are controlled individually by regulatory sequences TATA box – DNA that also helps to position RNA polymerase Enhancer sequences – DNA sequence to which proteins bind to regulate transcription

Gene Regulation:

Gene Regulation

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