Inflammation-Susi 4.24.13

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Diabetes Self Education:

Diabetes Self Education Inflammation and Insulin Resistance Presented By: Susanne Schenk, RN, Holistic Health Coach [email protected]

Inflammation and Immunity:

Inflammation and Immunity Survival Mechanism Fight Infection Heal Damage

Metabolism and Immunity:

Metabolism and Immunity Most basic requirement of life Well orchestrated and balanced system: linked and interdependent Hormones, enzymes, proteins function in both roles and regulate each other

Fight or Flight:

Fight or Flight The same machinery used to i lli c it this response also is used to divert energy and suppress the function of digestion. Same goes for infection. If the body is fixing damage its recruiting Infection fighting resources (catabolic) while diverting energy away from something like insulin signaling (anabolic).

Metabolic Challenge Under-Nutrition:

Metabolic Challenge Under-Nutrition A metabolic and immune balance is necessary for optimal health If we have starvation and malnourishment (metabolic challenge) immunity is suppressed and infection takes over (immune overload) resulting in: INFLAMMATION

Metabolic Challenge Over-Nutrition:

Metabolic Challenge Over-Nutrition Pendulum swings both ways! Over - nutrition also presents a metabolic challenge with implications of immune dysfunction and resulting: INFLAMMATION

Optimal Nutrition:

Optimal Nutrition Imperative for optimal immune response

Inflammatory Cytokines:

Inflammatory Cytokines In over-nutrition (obesity): inflammatory hormone cytokines are over expressed in the fat tissues. As if there was an injury! Over time: chronic inflammation results in impaired insulin action called: INSULIN RESISTANCE

Leptin:

Leptin Important in immune function Made in our adipose tissue Regulates appetite and body weight: tells us when and how much to eat, and tells the body what to do with the energy- insulin signaling Malfunctions in obesity: leptin resistance Result: chronic over insulinization, impaired immune response, leading to- INFLAMMATION

Lipids Cholesterol, Triglycerides, LDL, HDL:

Lipids Cholesterol, Triglycerides, LDL, HDL These are important in coordinating and regulating inflammation and metabolism Elevated plasma lipids are characteristic of obesity, infection, and inflammatory states Elevated plasma lipids result in insulin resistance, cardiovascular atherosclerosis

Signs of Metabolic Stress:

Signs of Metabolic Stress Excess weight : associated with a state of chronic, low grade inflammation. Elevated lipids : leading to faulty insulin action Inflammatory signaling in the cells become activated by this “metabolic stress” (Stress at a cellular level)

Inflammation and Insulin resistance:

Inflammation and Insulin resistance They reinforce each other: one causes the other and the other worsens the one!

Diseases of chronic Inflammation:

Diseases of chronic Inflammation Allergies, ADD/ADHD, Alzheimer’s, Anemia, Asthma, Autism, Arthritis, Celiac, Crohn’s Disease, Congestive Heart failure, Chronic Fatigue, Diabetes, Eczema, Fibromyalgia, Fibrosis, Gall Bladder Disease, GERD, Thyroid disease, Heart disease, Kidney disease, Lupus, Metabolic Syndrome, MS, Neuropathy, PCOS, Pancreatitis, Psoriasis, Rheumatoid Arthritis, Scleroderma, Stroke, and more…

Leaky Gut: Inflammation:

Leaky Gut: Inflammation The gut is semi permeable however; inflammation result s in much larger openings allowing passage of incompletely digested foods, and toxins to pass through to the blood. The body views these as intruders and mounts an immune attack.

What Causes Leaky Gut (gastrointestinal dysfunction):

What Causes Leaky Gut (gastrointestinal dysfunction) Drugs : Antibiotics, NSAIDS, Steroids drugs, Antacids, Diet : refined SUGAR , flour, artificial colors, flavors, artificial sweeteners, alcohol, soda, caffeine, high fructose corn syrup, food preservatives … Vitamin and mineral deficiencies : zinc, B 6, Vit. A, certain amino acids Infection : bacterial, viral, yeast Stress : chronic daily stress- inc. cortisol

How to Fix it!:

How to Fix it! Diet- stabilize blood glucose, remove food autoimmune triggers, gut flora, restore nitric oxide and glutathione pathways, include fermented foods, supplement if necessary: vitamins and minerals. Reduce Stress- Create conditions of love and appreciation, attitude, practice self care, meditation Exercise- resistance, interval, daily practice Sleep Social interactions

Gut Flora:

Gut Flora The ADA published a paper October 2010 acknowledging the connection between gut flora and metabolism and inflammation and obesity related disorders.

Factors that Influence Gut Flora:

Factors that Influence Gut Flora Vaginal delivery vs. C-section, Breast feeding vs. formula feeding Hospitalizations Antibiotic use Diet

2 divisions of Gut Flora:

2 divisions of Gut Flora Human gut hosts over a trillion bacteria and over 1000 species (Gastroenterology 2009; 136: 65-80) mouse studies show Bacteroidetes- found in guts of lean mice eating a mostly plant based diet Firmicutes- found in guts of mice with diet induced obesity.

Gut Flora Affects many aspects of a balanced system :

Gut Flora Affects many aspects of a balanced system hormone signaling- gut hormones, insulin the kind of energy metabolized from the food we eat the kind of fat that is conserved the integrity of the intestinal wall (think leaky gut) our behavior and mental health

Gut Flora metabolic endotoxemia :

Gut Flora metabolic endotoxemia Gut bacteria is definitively linked to the inflammatory state of obesity and insulin resistance because of leaking bacterial toxins out of the gut. essentially a low grade septicemia resulting in an immune response and resulting systemic inflammation

Healing Leaky Gut & Restoring Healthy Gut Flora:

Healing Leaky Gut & Restoring Healthy Gut Flora Plant based diet- Dark green leafy veggies. Cruciferous veggies. 50% or more raw fruits and veggies. If you eat meat eat the best quality and in moderation. Grass fed, Pasture raised (know where your food comes from) No GMO foods- Take a probiotic daily- diverse strains

Healing Leaky Gut & Restoring Healthy Gut Flora:

Healing Leaky Gut & Restoring Healthy Gut Flora Eat fermented foods- fermented vegetables, miso, natto, kefir, yogurt. Reduce stress- meditation, self care Supplement- minerals and vitamins: zinc, B-complex for stress, Vit. D, Vit. C (can help with overactive immune system- allergies) Krill oil- good omega 3 source Eliminate all processed foods- refined sugar, flour

Healing Leaky Gut & Restoring Healthy Gut Flora :

Healing Leaky Gut & Restoring Healthy Gut Flora Experiment with eliminating high allergen foods: dairy, wheat, gluten, eggs. Takes about 3-4 weeks to rest the gut then add them back one at a time. Notice how you feel. Include increasing amounts of raw foods: raw foods have powerful antioxidants, enzymes, and beneficial microflora

Top 11 Anti-Inflammatory Foods (dLife.com) :

Top 11 Anti-Inflammatory Foods (dLife.com) Salmon- anti-inflammatory fats Omega-3. Eat wild! All salmon from Alaska is wild. Atlantic salmon is farmed. Grass Fed beef, pork, and pastured poultry- as opposed to traditional grain fed. Olive Oil- Oleic acid- anti-inflammatory Salads- dark green leafy veggies and greens

Top 11 Anti-Inflammatory Foods (dLife.com) :

Top 11 Anti-Inflammatory Foods (dLife.com) Cruciferous Veggies- broccoli, cauliflower, brussels sprouts, kale - loaded with antioxidants and important mineral sulfur that the body needs to make it's own antioxidants. Cherries- packed with antioxidants and low glycemic Blueberries Turmeric- powerful natural anti-inflammatory compound

Top 11 Anti-Inflammatory Foods (dLife.com) :

Top 11 Anti-Inflammatory Foods (dLife.com) Ginger- blood glucose lowering and anti-inflammatory Garlic- natural anti-microbial and anti-viral to help fight infection Green tea-

Create a SMART goal around this subject:

Create a SMART goal around this subject Dietary change Stress management- meditation Exercise goal- incorporate 20 min interval 2x/week Shop at a farmers market Visit a CSA to buy food/meat/cheese Cut out sugar for 4 weeks Go grain free for 4 weeks- try paleo!

References:

References www.http://forcast.diabetes.org/magazine/your-ada/how-inflammation-affects-insulin-resistance www.http://care.diabetesjournals.org/content/33/10/2277.long www.ncbi.nlm.nih.gov/pmc/articles/PMC2518440

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