Transdermal drug delivery system by Kailash Vilegave

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transdermal drug delivery system, factors affecting transdermal delivery

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Presentation Topic: Transdermal Drug Delivery System (TDDS):

Presentation Topic: Transdermal Drug Delivery System (TDDS) Presented by Mr. Kailash Vilegave M. Pharm , Research scholar

Slide5:

1. Epidermis 75-150mm Stratum corneum 15-30 sheets of non viable biochemicaly active Stratum granulosum 3-5 sheets of non dividing keratinocytes Stratum spinosum 8-10 sheets of dividing keratinocytes Stratum basal. Hub for maturing/aging keratinocytes, melanocytes Dermis Hypodermis

Advantages of TDDS:

Advantages of TDDS

Slide9:

Transdermal delivery can increase the therapeutic value of many drugs via avoiding specific problems associated with the drug. E.g. GI irritation, lower absorption, decomposition due to ‘hepatic first pass’ effect. Treatment can be continued or discontinued whenever necessary. Greater patient compliance due to the reduction of dosing frequency. Easy elimination of drug delivery in case of toxicity. Transdermal medications deliver a steady infusion of a drug over an extended period of time. Adverse effects or therapeutic failure frequently associated with intermittent dosing can also be avoided.

Disadvantages of TDDS:

Disadvantages of TDDS It requires high blood concentration. It may be uneconomic. Transdermal drug delivery system is restricted to potent drug. Skin irritation (contact dermatitis) due to Excipient and absorption enhancers . Skin’s low permeability limits the number of drugs that can be delivered in this manner because the skin serves protective functions;

Uses:

Uses Nitroglycerin patches are used for the treatment of angina in lieu of sublingual pills. The first commercially available vapor patch of nicotine to reduce smoking was approved in Europe in 2007.

Factors Affecting of transdermal bioavailability:

Factors Affecting of t ransdermal bioavailability

Slide16:

Non irritating and non sensitizing to the skin

Mechanism of Transdermal Permeation:

Mechanism of Transdermal Permeation Transdermal permeation of a drug moiety involves the following steps- Sorption by stratum corneum Permeation of drug through viable epidermis Uptake of the drug moiety by the capillary network in the dermal papillary layer. The rate of permeation of drug moiety across the skin is governed by following equation: dQ/dt= P s (C d -C r ) Where, dQ/dt – Rate of permeation Ps – Permeability coefficient Cd – Concentration in donor compartment Cr – Concentration in receptor compartment

Types of TDDS:

Types of TDDS There are four main types of TDDS Single-layer Drug-in-Adhesive Multi-layer Drug-in-Adhesive Drug Reservoir-in-Adhesive Drug Matrix-in-Adhesive

Basic Components of TDDS:

Basic Components of TDDS Polymer matrix Drug Permeation enhancers. Pressure sensitive adhesives (PSAs) Backing membrane Release liner Other excipients

Recent Development of TDDS:

Recent Development of TDDS Several technologies have been successfully developed to provide a rate control over the release and the transdermal permeation of drugs. These technologies can be classified into four approaches as follows- Membrane permeation – controlled systems Adhesive dispersion – type systems. Matrix diffusion – controlled systems. Micro reservoir type systems.

Evaluation Parameters of TDDS:

Evaluation Parameters of TDDS The evaluation methods for ransdermal dosage form can be classified into following type- Physicochemical evaluation Thickness b)weight Uniformity In vitro evaluation a) Flow-Through Diffusion Cell b)The Paddle over Disc In vivo evaluation Animal models b)Human models Stability studies

Recent Techniques for Enhancing TDDS:

Recent Techniques for Enhancing TDDS Structure-Based Enhancement Techniques Electrically-Based Enhancement Techniques Velocity Based Enhancement Techniques Other Enhancement Techniques

Conclusion::

Conclusion: Transdermal drug delivery technologies are becoming one of the fastest growing sectors within the pharmaceutical industry. Despite some disadvantages, transdermal drug delivery offers many advantages capable of improving patient health and quality of life

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