Tablet Coating

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Recent advances in tablet coating & use of excipients

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tablet excipients AND COATING :

tablet excipients AND COATING Dr. Ganesh S.Bangale Assistant Professor Govt.College of Pharma cy ,Amravati

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Contents: Introduction What is mean by Excipients ? Factors affecting Types of Excipients Novel Drug Delivery System Sustained Release Technology Issues with Excipients Innovation in Pharmaceutical Excipients Advances in Tablet Excipients

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Introduction : Tablets are solid unit dosage forms consisting of active ingredient(s) and suitable pharmaceutical excipients . According to the Indian Pharmacopoeia they may vary in size, shape, weight, hardness, thickness, disintegration and dissolution characteristics, and in other aspects. They may be class yfied , according to the method of manufacture, as compressed tablets or molded tablets.

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What is mean by Excipients? An excipient is a pharmacologically inactive substance formulated alongside the active pharmaceutical of medication. Purposes served by excipient: Provide bulk to the formulation. Aid in handling of “API” during manufacturing. Provide stability and prevent from denaturation etc.

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Types of Excipients: Excipients are inactive ingredients used as carriers for the active ingredients in a pharmaceutical product. These may be classified into the following categories: Antiadherents Binders Disintegrants Coating Fillers and Diluents Glidants Lubricants Preservatives Sorbents Sweeteners

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The pharmaceutical ingredients must be stabilized toward: Environmental factors (air, water vapor, sunlight) Interactions between different ingredients in the drug or different functionalities in the same molecule Manufacturing stress (sterilization, compaction, etc.)

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The breakup of the tablets to smaller particles is important for dissolution of the drug and subsequent bioavailability. Disintegrators promote such breakup. To rupture or breakup of tablets, disintegrating agents must swell or expand on exposure to aqueous solution. Thus, the most effective disintegrating agents in most tablet systems are those with the highest wa-ter uptake property. In general, the more hydrophilic, the better disinte -grating agents are therefore highly hydrophilic. A list of typical disinte -grants is tabulated in Table DISINTEGRATORS:

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Binders promote the adhesion of particles of the formulation. Such adhesion enables preparation of granules and maintains the integrity of the final tablet. As listed in the Table , Commonly used binding agents include: starch, gelatin and sugars ( sucrose, glucose, dextrose, and lactose ) . BINDERS:

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Coatings Types of Coating : Sugar coating Film coating Enteric coating Most coated tablets are coated with hydroxypropylcellulose .

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Antifrictional Agents and Antiadherents Antiadherents are used to keep the powder from sticking to the tablet punch face during the manufacture of tablets. The most common is magnesium stearate Magnesium Stearate

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Lubricant is a substance capable of reducing or preventing friction, heat, and wear when introduced as a film between solid surfaces. It works by coating on the surface of particles, and thus preventing adhesion of the tablet material to the dies and punches. Glycerylmonostearate is one example of a lubricant. Lubricants play more than one role in the preparation of tablets as described below. LUBRICANTS:

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Novel Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration. NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. 15 Novel Drug Delivery System:

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Sustained Release Technology

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Issues with Excipients: Solubility: Almost 10% of the current marketed drug poorly soluble and almost 40% of new chemical entities are dropped due to solubility issues. Low solubility of drug candidates can translate into poor bioavailability.

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Three types of Innovation in Pharmaceutical Excipients : Modified Excipients: Excipients with established quality standards can be modified with regard to their impurity profile or their physical properties. Co- processed Excipients: Two or more Excipients are formulated without chemical changes in order to achieve new performance charecteristics which cannot be achieved by simple physical mixing.

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Novel Excipients: It is used for first time in a drug product of a new route of administration. Novel Excipients development is substantially similar to the non clinical developments of new active ingredients.

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Advances in Tablet Excipients : Increase the manufacturing efficiency. Better process performances. Improve manufacturing ability. Greater stabilization. Improve material properties. Targeting moieties to improve specificity. Taste-masking. New solubilizer with good tolerability. Reduce frequency of administration. Achievement of high dose.

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Thank you

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