Tumor antigen

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Tumor antigen:

Tumor antigen Eman Abd el-Raouf Ahmed

The content:

The content

Mechanism of tumor antigenesis :

Mechanism of tumor antigenesis

defination:

defination Tumor antigen is an antigenic substance produced in tumor cells .

Classification of tumor antigens :

Classification of tumor antigens *Tumor-Specific Antigens (TSA ) Tumor-Associated Antigens (TAA)

Tumor-Specific Antigens (TSA):

Tumor-Specific Antigens (TSA) Tumor-specific antigens represent fragments of novel proteins that are presented at the cell surface bound to the major histocompatibility complex class I molecules. In this form they are recognized by T lymphocytes (T cells) and eliminated.

Tumor-Specific Antigens (TSA):

Tumor-Specific Antigens (TSA)

Some tumor specific antigen:

Some tumor specific antigen UV-induced tumors Virus induced tumors Human T-cell leukemia virus Epstein –Barr virus Naso pharyngeal carcinoma Papilloma virus Cervical carcinoma

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES. :

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.

Tumor associated antigen:

Tumor associated antigen Definition: antigens that are highly correlated with certain tumor cells. They are not usually found, or are found to a lesser extent, on normal cells.

Tumor associated antigen:

Tumor associated antigen HCG-human chronic gonado tropin in testicular cancer α - feto protein in testicular cancer CA-125 in ovarian cancer PSA-prostate –specific antigen CEA- carcino embryonic AG

importance of Tumor associated antigen:

importance of Tumor associated antigen

Bio marker for tumor EX.prostate cancer:

Bio marker for tumor EX.prostate cancer

Tumor associated antigen:

Tumor associated antigen (1) The prostatic acid phosphatase (PAP) tumor-associated antigen and GM-CSF are incubated with the dendritic cells ; (2) the dendritic cells engulf the antigen and become activated; (3) the dendritic cells process the antigen; (4) activated dendritic cells are infused in the patient; (5) the dendritic cells activate T-cells; (6) T-cells attack PAP-bearing prostate cancer cells.

Identification of tumor-associated antigens as diagnostic and predictive biomarkers in cancer.:

Identification of tumor-associated antigens as diagnostic and predictive biomarkers in cancer.

Oncofetal antigens:

Oncofetal antigens

Importance of tumor antigen in general:

Importance of tumor antigen in general

references:

references http://www.annualreviews.org/doi/pdf/10.1146/annurev.iy.06.040188.002341 http://www2.massgeneral.org/wellman/faculty-hamblin-research-pdtinduced.htm http://www.slas.ac.cn/ts3.asp?id=54535 http://www.ncbi.nlm.nih.gov/pubmed/22318866

THANK YOU:

THANK YOU

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