lipid metabolism-fatty liver and alcohol metabolism

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LIPID METABOLISM- Fatty liver, Alcohol, Adipose Tissue metabolism:

LIPID METABOLISM- Fatty liver, Alcohol, Adipose Tissue metabolism Dr. Hariharan , V Assistant professor, Department of Biochemistry, Karpagam Faculty of Medical Sciences and Research, Coimbatore. Free ppt available in www.authorstream.com/ search drhari

At the end of this class you ll understand:

At the end of this class you ll understand Adipose tissue metabolism Regulation of fat mobilization in adipose tissue Brown Adipose tissue metabolism What is fatty liver and its pathogenesis Ethanol metabolism Free ppt available in www.authorstream.com/ search drhari

Regulation of VLDL secretion:

Regulation of VLDL secretion Increased VLDL is produced by liver when Increased lipid uptake in diet Increased carbohydrate uptake-especially fructose and sucrose Increased FFA in circulation High insulin / glucagon ratio Ethanol ingestion Free ppt available in www.authorstream.com/ search drhari

Fatty liver:

Fatty liver Accumulation of TAG in liver leads to fatty liver Etiology Raised level of FFA Starvation, uncontrolled DM, high fat diet Metabolic block in production of lipoproteins Ethanol, Essential FA deficiency, CCl4, puromycin , choline deficiency Free ppt available in www.authorstream.com/ search drhari

Fatty liver due to increased Plasma FFA:

Fatty liver due to increased Plasma FFA In starvation, uncontrolled DM there is excess lipolysis from adipose tissue leading to increased plasma FFA. Also in high fat feeding there is excess FFA in plasma. Liver cannot handle all this FFA and convert them to VLDL. So TAG accumulates in the liver. Free ppt available in www.authorstream.com/ search drhari

Fatty liver due to block in lipoprotein production:

Fatty liver due to block in lipoprotein production This id due to deficient formation of VLDL from TAG in the liver. So TAG accumulates leading to Fatty liver Block in apolipoprotein synthesis- CCl4, puromycin Block synthesis of lipoprotein from apoprotein and lipid-CCl4 Failure in provision of phospholipids to form lipoproteins- Dietary EFA deficiency Failure in secretory mechanism- orotic acid Free ppt available in www.authorstream.com/ search drhari

PowerPoint Presentation:

Free ppt available in www.authorstream.com/ search drhari Adipose tissue Liver VLDL TAG TG FA Beta oxidation Ethanol TAG EFA Phospho lipid Secretion Orotic acid Translation Apoprotein Puromycin , CCl4 CCl4  FFA Starvation Uncontrolled DM High fat diet

Pathology :

Pathology Extensive accumulation of TAG leads to fatty liver Fat accumulation will lead to chronic fibrotic changes in liver This progresses to cirrhosis of liver if the cause of fatty liver not removed Free ppt available in www.authorstream.com/ search drhari

Lipotrophic factors :

Lipotrophic factors Some chemicals which prevent formation of fatty liver are called lipotrophic factors They are Choline Vitamin E Essential fatty acids Free ppt available in www.authorstream.com/ search drhari

Metabolism of ethanol (Alcohol):

Metabolism of ethanol (Alcohol) Ethanol is dehydrogenated to acetal dehyde . Acetaldehyde is dehydrogenated to acetic acid by aldehyde dehydrogenase The increased NADH produced competes with reducing equivalents from fatty acids leading to reduced oxidation of fatty acids  leading to their accumulation TAG production  fatty liver. Free ppt available in www.authorstream.com/ search drhari Ethanol Acetaldehyde Alcohol dehydrogenase NAD + NADH2

PowerPoint Presentation:

The increased NADH/NAD leads to reduced availability of NAD for Lactate dehydrogenase  lactic acidosis Lactic acidosis inhibits uric acid excretion aggrevates Gout Free ppt available in www.authorstream.com/ search drhari

Summary :

Summary Free ppt available in www.authorstream.com/ search drhari

References:

References Harper Free ppt available in www.authorstream.com/ search drhari

PowerPoint Presentation:

Free ppt available in www.authorstream.com/ search drhari Thank you

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