STEROIDAL ALKALOIDS

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STEROIDAL ALKALOIDS:

STEROIDAL ALKALOIDS DR. NAUREEN SHEHZADI DEPARTMENT OF PHARMACEUTICAL SCIENCES, FACULTY OF PHARMACY, SUPERIOR UNIVERSITY

INTRODUCTION:

INTRODUCTION Steroidal alkaloids are the alkaloids with steroidal nucleus and N- atom. Steroidal nucleus refers to the carbon skeleton of four rings (cyclo pentano per hydro phenanthrene ring). N- atom in the alkaloids may be in closed ring or as side chain substituent . These group of alkaloids invariably occur in the plant kingdom as Glycosidal combination with carbohydrate moieties, therefore are known as “Glycoalkaloids”.

STEROIDAL RING:

STEROIDAL RING The basic ring systems present in the Veratrum alkaloids are not quite the same as seen in the usual steroidal nucleus, as present either in the cholesterol or in the aglycone residues of the cardiac glycosides. A: Normal steroidal structure B: Steroidal alkaloid structure

REPRESENTATIVE MEDICINAL PLANTS:

REPRESENTATIVE MEDICINAL PLANTS From plant sources are; Veratrum Solanum xanthocarpum Funtumia elastica From animal sources, include; Phyllobates aurotaenia Salamander

VERATRUM:

VERATRUM

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BOTANICAL ORIGIN Veratrum album FAMILY Melanthiaceae PART USED Dried r hizome CHEMICAL CONSTITUENTS Ceveratrum Alkaloids e.g. Protoveratrines A and B, veratridine, germine Jeveratrum Alkaloids e.g. veratramine, jervine and pseudojervine USES Proveratrines are used as an antihypertensive agent (exert their action through reflex inhibition of pressor receptors in the heart and carotid sinus). It also possesses emetic action. It is used in the treatment of toxemia of pregnancy

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Toxemia of pregnancy is a severe condition that sometimes occurs in the latter weeks of pregnancy. It is characterized by high blood pressure; swelling of the hands, feet, and face; and an excessive amount of protein in the urine. If the condition is allowed to worsen, the mother may experience convulsions and coma, and the baby may be stillborn .

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