tablet coating

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Comments

By: bapujipharmacy (117 month(s) ago)

Very nice presentation.. Please can u snd this ppt..? email:[email protected]

By: lakhviri (119 month(s) ago)

Mrs. Modi, The presentation is very good.This covers almost all the factors regarding coating operation,factors that may effect the coating process. Dear mam I am working in a pharmaceutical company and need this valuable presentation to share this my subordinates working in manufacturing area. My mail id is [email protected] Kindly send the presentation we shall be very thankful . Lakhvir Insan

By: nagesh4660 (121 month(s) ago)

good ppt.pls could send to [email protected]

By: chariv1122 (124 month(s) ago)

gud .............................

By: chariv1122 (124 month(s) ago)

good.................................

Presentation Transcript

TABLET COATING : 

TABLET COATING Mrs. Chetana D. Modi

Tablet Coating : 

Tablet Coating

What is the rationale for coating a solid dosage form? : 

What is the rationale for coating a solid dosage form? Coating of a solid dosage form is often designed to perform a specific function. For example; protection against moisture, taste masking pH or time controlled release. Tablets can be easily coated and a variety of products are available on the market. Generally, the coating process gives rise to; Increased bioavailability Improved patient acceptance Formulation stability The rationale for coating pharmaceutical dosage form such as a tablet can be categorised into three main headings: Therapy Technology Marketing

What is the rationale for coating a solid dosage form? : 

What is the rationale for coating a solid dosage form? Therapy To minimise irritation of the oesophagus and stomach. Minimise inactivation in the stomach. Improve drug effectiveness. Improve patient compliance e.g. easier to swallow, masks unpleasant taste.

What is the rationale for coating a solid dosage form? : 

What is the rationale for coating a solid dosage form? Technology Minimise dust formation and contamination with respect to tablets. Masks batch differences in the appearance of raw materials. Facilitates their handling on high speed automated filling and packaging equipment. Improves drug stability e.g. Protection of active ingredient from environment such as sunlight, moisture.

What is the rationale for coating a solid dosage form? : 

What is the rationale for coating a solid dosage form? Marketing Aid sales appeal as improved appearance and acceptability with respect to gloss and colouration. Mask unpleasant taste. Improve product identity.

Key factors for tablet coating : 

Key factors for tablet coating

Tablet properties : 

Tablet properties

Key factors for tablet coating : 

Key factors for tablet coating

Coating process : 

Coating process Tablet coating is the application of a coating composition to a moving bed of tablets with the concurrent use of heated air to facilitate evaporation of the solvents. The distribution of the coating is accomplished by the movement of the tablets either perpendicular (coating pan) or vertical (air suspension coater) to the application of the coating composition.

Key factors for tablet coating : 

Key factors for tablet coating

Equipments : 

Equipments Energy efficient Automated system Total coating time is reduced Reduce man power

Pelligrini pan (baffled) : 

Pelligrini pan (baffled)

Glatt coater : 

Glatt coater

hi-coater : 

hi-coater

Fluidized bed coater : 

Fluidized bed coater

Key factors for tablet coating : 

Key factors for tablet coating

Parameters : 

Parameters Application zone Drying and spreading zone Perforated Coating pan

Parameters : 

Parameters Air capacity Temperature and humidity of air Coating composition Ingredients Solvents Visocosity Tablet surface area Size of the tablet Debossed features Equipment efficiency

Key factors for tablet coating : 

Key factors for tablet coating

Facility and ancillary equipment : 

Facility and ancillary equipment Coating operation should be designed to meet cGMP Adequate space for Coating equipments Solution preparation IPQC Safety requirements for explosive and toxic solvents, ventilation and explosion-proofing are required. EPA (federal environmental protection agency) have regulations for organic solvents

Key factors for tablet coating : 

Key factors for tablet coating

Automation : 

Automation Sensors Regulating devices for temp., airflow, spray rate, pans speed, Programmable controller Perforated pans-better efficiency Air inlet Air outlet Perforated pan Computer attached

Tablet Coating : 

Tablet Coating Types of coatings sugar coating film coating press coating (compression coating)

Sugar Coating : 

Sugar Coating stages involved sealing of tablet core subcoating Smoothing (syruping) Finishing polishing

Sealing : 

Sealing To prevent moisture penetration If no sealing-overwetting of tablet-absorb moisture-tablet softening-change in physical and chemical properties of drug. Shellac-effective polymer for sealing But on aging-polymerization of shellac-disntergration dissolution time increases.

Subcoating : 

Subcoating

Syruping : 

Syruping

Polishing : 

Polishing

Film Coating : 

Film Coating involves spraying a solution of polymer + pigments + plasticizers onto a rotated, mixed tablet bed forms a thin, uniform film on tablet surface

Film Formation : 

Film Formation latex particles dispersed in aqueous phase formation of thin film with water evaporation through film continuous film

Methods of film coating : 

Methods of film coating

Slide 35: 

For adequate mixing and uniform air distribution Too low-overwetting-tablet sticking Too high-no enough time to dry-rough coating Large-10 to 15 RPM-Non aqueous Small-3 to 10 RPM-aqueous Airless highpressure Air atomization low pressure By nozzle orifice Finely subdivide dplets Fine-dry before reaching to bed Large-orange peel effect. Depends on orifice diameter, nozzle configuration, fluid viscosity Depends on degree of mixing and drying efficiency. Depends on qty applied and spray width. Sensitivity of film former and product core Seasonal fluctuation, supply and exhaust air flow

Fluidized bed Process : 

Fluidized bed Process

Materials used in film coating : 

Materials used in film coating Solubility in all solvents Solubility required for intended use Elegant looking production Stability in presence of heat, light, air and moisture No color, odor and taste. Compatibility with other additives No bridging and filling of debossed tablets.

Non-enteric material : 

Non-enteric material

Enteric material : 

Enteric material To protect acid labile drugs To prevent gastric distress or nausea due to irritation For local action in intestine Delivery in small intestine and at a target site in concentrated form For delayed release and repeat action tablet.

Ideal enteric coating material : 

Ideal enteric coating material Resistance to gastric fluid Permeability to intestinal fluid Compatibility with other ingredients Stability. Should not aging Continuous film formation Non-toxicity Low cost Ease of application during coating

Enteric coating material : 

Enteric coating material Cellulose acetate phthalate (CAP) Acrylate polymers Hydroxypropyl methycellulose phthalate Polyvinyl acetate phthalate

Coating Problems : 

Coating Problems picking/chipping roughness sticking film cracking/peeling

Press Coating : 

Press Coating use of compression to form coat around a pre-formed core used mainly to separate chemically incompatible materials also dual release patterns possible

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