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Peptides Peptides from Greek language πεπτός peptós “digested” derived from πέσσειν péssein “to digest” are short chains of amino acids linked by peptide amide bonds.1 The simplest peptides are dipeptides followed by tripeptides tetrapeptides etc. A polypeptide is a long continuous and unbranched peptide chain. Hence peptides fall under the broad chemical classes of biological oligomers and polymers alongside nucleic acids oligosaccharides and polysaccharides etc. Peptides are distinguished from proteins on the basis of size and as an arbitrary benchmark can be understood to contain approximately 50 or fewer amino acids.23 Proteins consist of one or more polypeptides arranged in a biologically functional way often bound to ligands such as coenzymes and cofactors or to another protein or other macromolecule DNA RNA etc. or to complex macromolecular assemblies.4 Finally while aspects of the lab techniques applied to peptides versus polypeptides and proteins differ e.g. the specifics of electrophoresis chromatography etc. the size boundaries that distinguish peptides from polypeptides and proteins are not absolute: long peptides such as amyloid beta have been referred to as proteins and smaller proteins like insulin have been considered peptides. Source - Wikipedia

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