slide 1: Scenario of Precision Medicine in MENA Region
Precision medicine is a specific type of approach that allows doctors to select treatments for patients
based on the genomic understanding of the patients’ disease. Recent advancements in Research and
Development have sped up the pace of research in the MENA region. Precision medicine is an evolving
method for a disease that analyses a persons’ variability in genes environment and lifestyle which is
specific to that person. The approach will also help doctors and researchers to foresee which treatment
and prevention strategy for a particular disease will work and in which group of people. Predominantly
this region is considered a highly prevalent region of consanguineous marriage and eminent incidence of
some Mendelian disorders such as Muscular dystrophy Thalassemia and Cystic fibrosis. This is the
region where various disease studies are facing the problem of too many variants per sequencing
experiment.
The UAE is among few countries in the MENA region which is adopting modern innovative healthcare
approaches to combat such issues. Increase in funding and revolutionary initiatives have led to
astonishing growth of the UAE healthcare market. To further streamline its process the country’s current
agenda Vision 21 focuses on developing world-class healthcare infrastructure. Personalised medicine is
one of the novel therapy approach where researchers and physicians of the country are focusing owing to
the increased prevalence of non-communicable diseases such as diabetes and cancer. HIV prevalence is
categorized as one of the lowest in the world as per the Global AIDS Response Progress Report 2014
however among the migrants higher prevalence is notably observed.
slide 2: The optimism lies in the research advances relating to genetic diseases and expansion efforts of
laboratories’ offerings to include personalised diagnostic services across UAE In April 2018 the Middle
East’s first C4IR affiliate centre was launched in UAE in collaboration with the Ministry of Cabinet
Affairs and the Future. C4IR UAE will strengthen the Forum’s strategic relationship with the UAE and
will emphasize on precision medicine as well as blockchain artificial intelligence and machine learning.
Other countries in the MENA region are also testing the waters by experimenting in personalised
medicine. Speaking of other countries one such example is of Qatar where in order to facilitate genome
understanding for precision medicine significant allele SNPs and indels were identified and
the GRCh37 reference genome was modified at these sites to produce the Qatar Reference Genome
QTRG.
Also in December 2016 The Magdi Yacoub Heart Foundation Egypt started a new research centre
in Aswan with the main focus directed towards precision medicine and personalised therapies. A
researcher from this centre clarifies that with the help of the latest genome sequencing technology this
information gap can be closed and new personalised or precision treatments can be used for the better
cure of the diseases.
The MENA region without a doubt has witnessed impressive growth in the healthcare sector with high
quality of research aiming to innovate the diseases are treated. Several educational centres and
investigators have started to study the scope of precision medicine in treating disorders which are poised
to be a burden on the region. Moreover initiatives to incorporate genetic research and creating a new
focus on translational research is also being carried out by the laboratories and health institutes.
The feasibility of utilizing precision medicine in the MENA region for treating diseases can be
accelerated by the population scale genome projects state art infrastructure awareness and acceptance of
genomics and a universal healthcare system. Although some of the genome projects from the region are
still under consideration however it is to be emphasized that with the collaborative efforts between
projects in the region suitable funding creation of regulatory frameworks together with clear policies and
procedures that govern IP would empower successful commercial manipulation of the knowledge base.
Consequently collaborations and consensus will be the key success of precision medicine in this region.
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Source: DelveInsight – www.delveinsight.com