Nimesulide Medicine - Formulation, Properties, Clinical Study, Benefit

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Nimesulide Medicine - Formulation, Properties, Clinical Study, Benefits and Dosage:

Nimesulide Medicine - Formulation, Properties, Clinical Study, Benefits and Dosage


Contents Introduction Chemical Formulation Properties of Nimesulide Clinical Study Benefits Dosage Conclusion Disclaimer

Introduction :

Introduction Nimesulide ( Nise 100mg ) is an NSAID ( Non-steroidal Anti-inflammatory Drugs) a preferential COX II inhibitor a multi-factorial mode of action a analgesic drug a antipyretic drug Fg.1: Nise 100 mg

Chemical Formulation :

Chemical Formulation Chemical Formula: C 13 H 12 N 2 O 5 S . Chemical Name : 4-nitro-2-phenoxymethanesulfoanilide and belongs to BCS category II. exhibit low and variable oral bioavailability. may be a selective Cox-2 anti-inflammatory drug. by-product of p- nitrophenyl methane series sulfa . belongs to selective COX-2 inhibitors. Fg.2:Structure of Nimesulide

Properties of Nimesulide :

Properties of Nimesulide 1.Pharmacokinetic: acts as an aggressive inhibitor of histamine discharge in-vivo and in-vitro. antihistaminic and anti-allergic properties. Gastro-duodenal symptoms . beginning of pain relieving and antipyretic activity : is 1.6– 3.17 h and the term of activity is 10– 12 h. 2 . Absorption: It is well absorbed from the GI tract following oral intake. 3. Pinnacle Plasma Levels: PPL: 1-3 hours. the study state is accomplished in 24 to 36 hours ( Offer administrator of 100 mg).

Clinical Study :

Clinical Study Nimesulide's remedial incentive in viable and quickly controlling aggravation and agony is bolstered by indispensable clinical proof. The drug prescribed is supposed to be suitable when the advantage can give to a specific patient exceed the dangers related to its utilization . Hence , a cautious examination of individual hazard factors is along these lines of urgent significance.

Benefits of Nimesulide:

Benefits of Nimesulide Nimesulide 100mg treats : Headache, back pain, Sprains and strains. intense pain and primary dysmenorrhoea. fascinating results by acting quick and fast effects. No facet effects and gastro-duodenal symptoms. Rheumatic inflammatory disease, degenerative joint disease, alternative chronic joint disorders treatment. Musculoskeletal disorders, Thrombophlebitis and Cancer. Agonizing degenerative joint pains.

Nimesulide Dosage :

Nimesulide Dosage Adults: 100 mg twice daily after meals. Children: 5 mg/kg of body weight in 2 or 3 divided doses. The minimum effective dose should be used for the shortest duration to reduce the undesirable effects. The maximum duration of a treatment course with Nimesulide is 15 days.


Conclusion Analgesics form a key part of a treatment, where pain and inflammation is experienced. Nimesulide well known for its analgesic or pain-relieving properties. Offers the aforementioned benefits and the drug’s effectiveness. Therefore, Nimesulide is widely used to treat ailments causing acute pain.


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