tablet coating

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Presentation Transcript

Tablet coating : 

Tablet coating Presented by: Gautam Singhvi

Aspects of tablet coating: : 

Aspects of tablet coating: I. Therapy i) Avoid irritation of stomach ii) Avoid bad taste iii) Avoid inactivation of drug in the stomach iv) Prolong dosing interval v) Improve patient compliance

Aspects of tablet coating: : 

II. Technology i) Reduce influence of moisture ii) Avoid dust formation iii) Reduce influence of atmosphere iv) Improve drug stability v) Improve shelf life Aspects of tablet coating:

Aspects of tablet coating: : 

III. Marketing i) Avoid bad taste ii) Improve product identity iii) Improve appearance and acceptability Aspects of tablet coating:

Slide 5: 

Tablet coating is the application of coating composition to moving bed of tablets with concurrent use of heated air to facilitate evaporation of solvent. Basic principle of tablet coating

Type of tablet coating: : 

Type of tablet coating: Sugar coating Film coating Enteric coating Controlled release coating Specialized coating Compressed coating Electrostatic coating Dip coating Vacuum film coating

Process: : 

Process: Coating machine and process: Standard coating pan Perforated coating pan Fluidized bed coater Process parameters inlet temp, outlet temp., pan speed, spray rate, pan load, solid content of coating solution, atomization pressure, nozzle-to-bed distance, drying time. Coating solution

Sugar coating : 

Sugar coating Sugar coating process involves five separate operations: I. Sealing/Water proofing: provides a moisture barrier and harden the tablet surface. e.g :Shellac, Zine, Cellulose acetate phthalate (CAP), Polyvinylacetate phthalate, Hyroxylpropylcellulose, Hyroxypropylmethylcellulose etc.

Sugar coating : 

Sugar coating II. Subcoating: causes a rapid buildup to round off the tablet edges. Generally two methods are used for subcoating: i)The application of gum based solution followed by dusting with powder and then drying. This routine is repeated until the desired shape is achieved. ii)The application of a suspension of dry powder in gum/sucrose solution followed by drying.

Sugar coating : 

III. Grossing/Smoothing: it is specifically for smoothing and filing the irregularity on the surface generated during subcoating. It also increases the tablet size to a predetermined dimension. IV. Colouring: gives the tablet its colour and finished size. V. Polishing: produces the characteristics gloss. Polishing is achieved by applying the mixture of waxes like beeswax, carnubawax, candelila wax or hard paraffin wax to tablets in polishing pan. Sugar coating

Film Coating : 

Film Coating

Film Coating : 

Film Coating

Film Coating : 

Film Coating Materials used in film coating I. Film formers, which may be enteric or non-enteric II. Solvents III. Plasticizers IV. Colourants V. Opaquant-Extenders VI. Miscellaneous coating solution components

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