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Acetaminophen Molecular Imprinted P-Phenylenediamine Glassy Carbon
We report for the first time on the elaboration of a molecular imprinted polymer (MIP) based on the electropolymerization of pphenylenediamine on a glassy carbon electrode (GCE) and dedicated to acetaminophen control in commercialized tablets. Cyclic voltammetry (CV) and square wave voltammetry (SWV) electrochemical technics are exploited to elaborate a low-cost, reproducible and very simple methodology for the determination of acetaminophen in pharmaceutical tablets. A linear evolution between the response currents at Ep=+0.52 V/SCE and acetaminophen concentration ranging from 01 mg/L to 500 mg/L is determined for MIP sensor elaborated with a limit of detection (LOD) of 30 μg/L at a signal to noise ratio (S/N) of 3. An excellent selectivity for the paracetamol vs p-nitrophenol, dopamine and dopac interferents molecules is demonstrated and recovery values obtained between 97.4% and 101.4% indicating the accuracy and repeatability of the proposed method dedicated to the quality control of commercialized tablets.
Tags:
Acetaminophen , Electrode , Glassy
By:
tsijournals
Science & Technology
29 months ago
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L&OD Report
Presenting for the first time ever - an indepth report on the changing paradigms and unique trends of the L&D industry in India. Download the full report here: http://www.24x7learning.com/reports/
Tags:
Lod , Report
By:
24x7learning
News & Reports
78 months ago
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