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emin-vitroem-drugdrug-interaction-studies-of-apixaban-with-atorvastati
Poly-pharmacy of cardiovascular drugs is a common cause of a few unexpected drug-drug interactions (DDI)which may lead to the occurrence of the adverse effects of the drugs co-administered. The High Performance ThinLayer Chromatography method was adopted for the analysis of apixaban and atorvastatin. The method validation forthe individual drugs was carried out according to the ICH guidelines. The validated method was applied for the invitro drug-drug interaction study is at the biological pH of stomach at 4.0, of blood at 7.4 and intestinal condition at9.0. The aim of the study is to evaluate the effect of atorvastatin under the simulated conditions of the human body.The in vitro drug-drug interaction studies suggest that the drug apixaban does not have any profound change at pH4 and 9 when present with atorvastatin. When apixaban and atorvastatin are present at a pH 7.4 the significantvariation in the detector response is indicative of the decrease in the level of apixaban
Tags:
ToxicologyJournals , ToxicologyOpen Access Journals , ToxicologyPeer Review Journals , ToxicologyResearch Journals , ToxicologyScholarly Journals
By:
jessicamia1
Science & Technology
16 months ago
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Lipitor Lawsuit
Lipitor (atorvastatin) has become one of the more popular drugs available by prescription to treat high cholesterol. You might have seen commercials for this drug on TV, heard about it on the radio, as well as in newspapers, magazines and online advertisements. While these ads do list the potential side effects of using Lipitor and the other drugs in its class of medications called HMG-CoA reductase inhibitors (statins), many doctors continue to prescribe it to their patients.Visit our site http://lipitorlawsuitsettlements.com/ for more information on Lipitor Lawsuit
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Lawsuit , Lipitor
By:
LipitorLawsuitx
Entertainment
92 months ago
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Drug Interactions of Statins
It is contraindicated to use statins like Simvastatin and Lovastatins along with medications such as Azole Antifungals, Macrolide Antibiotics, Antivirals (Protease Inhibitors), Fibrates and Potent CYP3A4 Inhibitors. The drugs interacting majorly with statins include weak CYP3A4 inhibitors, CYP3A4 inducers, Warfarin, Niacin, Colchicine, Daptomycin and Grapefruit Juice.
Tags:
Atorvastatin , Drug Interactions of Statins , HMG CoA Reductase Inhibitors , Lovastatin , SIMVASTATIN
By:
nainamohamedpakk
Education
58 months ago
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Drug Interactions of Fibrates
· Contraindicated Combinations of Fibrates include Fibrates & Ciprofibrate, Gemfibrozil & Repaglinide, Gemfibrozil & Dasabuvir and Gemfibrozil & Simvastatin.· Major Interactions of Fibrates include Fibrates & Ezetimibe, Fibrates & Sulfonylurea Antidiabetics (Glyburide, Glipizide, Glimepiride, etc), Gemfibrozil & Other Statins (Lovastatin, Atorvastatin, Fluvastatin, Pravastatin), Gemfibrozil & Colchicine, Fenofibrate & Anticoagulants, Bezafibrate & Bile acid Sequestrants (Cholestyramine, Colestipol, Colesevelam).
Tags:
Antihyperlipidemics , Clofibrate , Drug Interactions of Fibrates , Fenofibrate , Gemfibrozil
By:
nainamohamedpakk
Education
57 months ago
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