The Mouse / Human Anatomy Project: The Mouse / Human Anatomy Project Jim Kadin The Jackson Laboratory


mouse-human anatomyproject objective: mouse-human anatomy project objective To provide a mapping and harmonization of anatomical descriptors as they are currently used for murine and human models by Mouse Genome Informatics and the NCI Thesaurus


Slide3: to facilitate closer integration of human and mouse cancer data to promote the use of the mouse as model for cancer research to accelerate translation of basic research discoveries into new clinical therapies


Participants: Participants MGI project team Terry Hayamizu Jim Kadin Martin Ringwald NCI project team Sherri De Coronado Gilberto Fragoso Nick Sioutos Wen-Ling Shaiu Frank Hartel BAH Michael Keller Brian Davis NCI VCDE-WS lead George Komatsoulis


mouse-human anatomyproject activities: mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus


mouse-human anatomyproject activities: mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus


mouse-human anatomyproject activities: mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus


Specific Tasks for Comparative Analysis: Specific Tasks for Comparative Analysis Compare the anatomy ontologies - e.g. overall structure, local similarities and differences, and differences in granularity Identify reasons for all types of differences. Identify anatomical concepts that are identical and/or equivalent ˛ i.e. “matching terms” Identify concepts defined in one context, but missing in the other ˛ i.e. possible terms to add to other ontology


Slide10: Legend Red: non-matching terms Black: matching terms Straight blue lines: terms that match and the ontology structures match Wavy blue lines: terms that match but ontology structures don’t Comparison of High Level Structure


mouse-human anatomyproject activities: mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus


mouse-human anatomyproject activities: mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus


Harmonization at the Top Levels: Harmonization at the Top Levels


Slide15: Example of Detail Level Harmonization Before


Slide16: Example of Detail Level Harmonization After


mouse-human anatomyproject activities: mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus


mouse-human anatomyproject activities: mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus


Ongoing: Ongoing MGI will continue to maintain the MA and mappings Have agreed on procedures for bi-directional updates EVS is working on incorporating MA into the NCI Thesaurus