Lung Cancer and its causes

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Lung Cancer:

Lung Cancer Presented to : Zaig 2000 Presented by:

Outline:

O utline Introduction Sign and Symptoms Causes Treatment Gene Protein Drug Ligand analysis with the help of VMD

Introduction:

Introduction Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. The main types of lung cancer are: small-cell lung carcinoma (SCLC ) non-small-cell lung carcinoma (NSCLC )

Sign and Symptoms:

Sign and Symptoms Coughing weight loss bone pain fever chest pain wheezing

Causes:

Causes Smoking Smoking , particularly of cigarettes, is by far the main contributor to lung cancer. Radon gas Radon is a colorless and odorless gas generated by the breakdown of radioactive radium, which in turn is the decay product of uranium, found in the Earth's crust. Air pollution Air pollution has a small effect on increasing the risk of lung cancer.

Treatment:

Treatment Surgery Radiotherapy Chemotherapy

Gene:

Gene Cause by oncogene . Mutations in the K- ras proto-oncogene are responsible for of lung adenocarcinomas.

Proto-oncogene:

Proto-oncogene A proto-oncogene is a normal gene that can become an oncogene due to mutations.

  RAS :

RAS Ras is the member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviors. Ras proteins function as binary molecular switches that control intracellular signaling networks.

Chemotherapy:

Chemotherapy In SCLC, cisplatin and etoposide are most commonly used. NSCLC is often treated with cisplatin or carboplatin.

cisplatin:

cisplatin

Structural Properties:

Structural Properties Pharmacophore Feature Binding Interaction No Aromatic ring Ionic Bonding No Electron Donor Covalent bonding

etoposide:

etoposide

Structural Properties:

Structural Properties Pharmacophore Feature Binding Interaction 7 Aromatic ring Hydrogen bonding 1 Electron Donor No Dipole-Dipole interaction 3 Hydrogen Bond Donor Van der Waal’s forces 1 Hydrogen Bond Donor Hydrophobic interactions

carboplatin:

carboplatin

Structural Properties:

Structural Properties Pharmacophore Feature Binding Interaction no Aromatic ring Ionic Bonding 1 Electron Donor No Dipole-Dipole Interactions 3 Hydrogen Bond Donor Van der Waal’s forces 1 Hydrogen Bond Donor Covalent bonding

Drug Side Effects:

Drug Side Effects Cisplatin hearing problems drowsiness, mood changes, increased thirst, loss of appetite, nausea and vomiting. Etoposide fever, chills, body aches, flu symptoms, sores in your mouth and throat pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating Carboplatin severe or ongoing vomiting stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

PowerPoint Presentation:

Ligands with binding interactions

1O1S :

1O1S

2CHW:

2CHW

2CHZ:

2CHZ

4EPW:

4EPW

4GTM:

4GTM

PowerPoint Presentation:

http://www.rcsb.org/pdb/home/home.do http://www.rcsb.org/pdb/results/results.do?qrid=B9EC27A4&tabtoshow=Current http://www.drugs.com/sfx/carboplatin-side-effects.html http://www.drugs.com/sfx/etoposide-side-effects.html http://www.drugs.com/sfx/cisplatin-side-effects.html

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