lipid lowering drugs

Views:
 
Category: Education
     
 

Presentation Description

No description available.

Comments

Presentation Transcript

PowerPoint Presentation:

LIPID-LOWERING DRUGS

PowerPoint Presentation:

LIPID-LOWERING DRUGS “Several drugs decrease plasma LDL. Drug therapy is used in addition to dietary measures and correction of other modifiable cardiovascular risk factors .” The main agents used clinically are: statins: 3-hydroxy-3-methylglutaryl-coenzyme A (HMG- CoA) reductase inhibitors fibrates inhibitors of cholesterol absorption nicotinic acid or its derivatives Fish oil derivatives.

PowerPoint Presentation:

Mechanism of action of lipid-lowering drugs:

PowerPoint Presentation:

STATINS: HMG-COA REDUCTASE INHIBITORS: Clinical uses of HMG-CoA reductase inhibitors (statins, e.g. simvastatin, atorvastatin) Secondary prevention of myocardial infarction and stroke in patients who have symptomatic atherosclerotic disease . Primary prevention of arterial disease in patients who are at high risk because of elevated serum cholesterol concentration, especially if there are other risk factors for atherosclerosis. Atorvastatin lowers serum cholesterol in patients with homozygous familial hypercholesterolaemia. In severe drug-resistant dyslipidaemia . Contraindicated in pregnancy.

PowerPoint Presentation:

Adverse effect: Myalgia gastrointestinal disturbance, raised concentrations of liver enzymes in plasma Insomnia myositis angio-oedema.

PowerPoint Presentation:

FIBRATES Clinical uses of fibrates (e.g. gemfibrozil, fenofibrate): Mixed dyslipidaemia, provided this is not caused by excessive alcohol consumption. Fenofibrate is uricosuric, which may be useful where hyperuricaemia coexists with mixed dyslipidaemia. In patients with low high-density lipoprotein and high risk of atheromatous disease. Combined with other lipid-lowering drugs in patients with severe treatment-resistant dyslipidaemia. This may, however, increase the risk of rhabdomyolysis.

PowerPoint Presentation:

Adverse effect: Myositis M yoglobinuria A cute renal failure. H ypertriglyceridaemia Gastrointestinal symptoms; P ruritus Rash C holecystectomy

PowerPoint Presentation:

DRUGS THAT INHIBIT CHOLESTEROL ABSORPTION EZETIMIBE Clinical use of drugs that reduce cholesterol absorption: ezetimibe or bile acid-binding resins (e.g. colestyramine) As an addition to a statin when response has been inadequate (ezetimibe). For hypercholesterolaemia when a statin is contraindicated. Uses unrelated to atherosclerosis, including: - pruritus in patients with partial biliary obstruction. - bile acid diarrhoea, for example caused by diabetic neuropathy .

PowerPoint Presentation:

NICOTINIC ACID Clinical uses of nicotinic acid derivatives As adjunct to a statin and diet in dyslipidaemia, especially when associated with low HDL and raised triglycerides. When a statin is contraindicated.

PowerPoint Presentation:

FISH OIL DERIVATIVES Fish oil is contraindicated in patients with type IIa hyperlipoproteinaemia because of the increase in LDL that it causes. A preparation of omega 3-acid ethyl esters is licensed in the UK for prevention of recurrent events after myocardial infarction in addition to treatment of hypertriglyceridaemia; it causes less increase in LDL and fewer problems with fishy odour, weight gain and dyspepsia than the older fish oil preparations.

PowerPoint Presentation:

REFERANCE RANG AND DALE’S Pharmacology

authorStream Live Help