logging in or signing up LIPO PROTEIN METABOLISM vuddandiprabodh Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 1111 Category: Education License: All Rights Reserved Like it (1) Dislike it (0) Added: February 20, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... By: afjam (42 month(s) ago) Dear Dr. S.Prabodh I'm lecturer in biochemistry and would you please kindly let me to copy your PPT in LIPO PROTEIN METABOLISM. thank you. sincerely yours Dr.M. Rahbani Nobar Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript LIPO PROTEIN METABOLISM : LIPO PROTEIN METABOLISM Dr. V. Siva Prabodh MD Associate Professor Dept. of Biochemistry NRI Medical College Lipoproteins : Lipoproteins These are molecular complexes which contains Lipids & proteins Function: Transports Lipids in blood. Classification of Lipoproteins Five Major classes Chylomicrons VLDL LDL HDL FFA with albumin Lipo proteins are seperated by Ultra centrifugation/Electrophoresis : Lipo proteins are seperated by Ultra centrifugation/Electrophoresis Slide 4: Chylomicrons: Synthesized in the Intestine. Transport Exogenous lipids (Dietary Lipids) 99% Lipids, 1% protein, Density very less. 2) VLDL : Produced in the Liver & Intestine Transport Endogenous lipids Slide 5: 3) LDL : Formed from VLDL in blood Transport cholesterol from Liver to other tissues. 4) HDL : Mostly synthesized in Liver Transport cholesterol from peripheral tissues to Liver (Reverse cholesterol transport) 5) FFA with albumin: Each molecule of albumin hold 20-30 molecules of FFA. Apoproteins : Apoproteins The protein forms of Lipoproteins are known as Apolipoproteins or Apoproteins. Functions: Structural component – apo A, apo B, apo B100 apo C Recognizes surface receptors – apo E, apo B100 Activate Lipoprotein Lipase – apo C II LDL : LDL Low density Lipoprotein is formed from VLDL and the Intermediate is IDL. LDL contain high cholesterol and less TAG. Function:– Supply cholesterol to extra hepatic tissues. LDL particles bind to specific receptors over the cell membrane which are clathrin coated pit Apo B100 recognizes the receptors over the cell membrane Deficiency of LDL receptors leads to Increased circulating LDL and hence cholesterol increases Eg: Type IIa hyperbeta lipoproteinemia. HDL : HDL High density Lipoproteins (Three types HDL1, HDL2, HDL3) Cholesterol is transported from Extra hepatic tissue to Liver where it is excreted in the form of bile. Anti – atherogenic, Good cholesterol Intestinal cells synthesize HDL and release into blood. LCAT: Lecithin cholesterol Acyl transferases, transfer PUFA from Lecithin to cholesterol to form cholesterol ester, which moves into interior of HDL APO A I activates LCAT The HDL with more cholesterol are taken up by Liver cells, and cholesterol is released into Liver. (Reverse cholesterol transport) HYPER LIPOPROTEINEMIAS : HYPER LIPOPROTEINEMIAS Slide 11: Familial hypercholesterolemia (type II a) Slide 13: Thank you You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.