Directly Compresible Vehicle

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Directly Compresible Vehicle By Mr. Vishal Shelke https://youtube.com/vishalshelke99 https://instagram.com/vishal_stagram Introduction These are the diluents or fillers designed to make up the required bulk of the tablets. These are inactive ingredients that are added to tablets in addition to the active drug. Some very common diluents in tablets include lactose and their derivatives, starch, cellulose derivatives. Used in the direct compression of the tablets. Requirements For A Good DCV : Non-toxic and acceptable to the regulatory agencies. Low cost. Physiologically inert. Must be color-compatible Stability. Controlled particle size. Good flowability. What is Direct compression ? Direct compression (DC) is the tabletting of a blend of ingredients i.e. the compression mix, without a preliminary granulation or aggregation process. The compression mix contains the active pharmaceutical ingredient (API) blended with one or more excipients. The excipients may include binders, fillers/diluents, disintegrant and lubricants. Advantages of DC : More Economic compare to wet granulation since it requires fewer unit operations. Documentation and validation requirements are reduced. It requires less equipment REFERENCES - * Pharmaceutical dosage forms tablet Vol-II second edition lachman leon, lieberman H.A. Page.No 77-160.

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1 PDEA’s SGRS College of Pharmacy, Saswad PRESENTATION ON DIRECTLY COMPRESSIBLE VEHICLE PRESENTED BY: Mr. Vishal Dattatraya Shelke. M.Pharm Sem - I GUIDED BY : Mrs. S.S Mutha DEPARTMENT OF PHARMACEUTICS

CONTENTS:

CONTENTS 2 Introduction of Directly Compressible Vehicle Requirements for Good DCV What is Direct Compression ? Advantages Disadvantages Classification of DCV References

DIRECTLY COMPRESSIBLE VEHICLE:

DIRECTLY COMPRESSIBLE VEHICLE Introduction These are the diluents or fillers designed to make up the required bulk of the tablets. These are inactive ingredients that are added to tablets in addition to the active drug. Some very common diluents in tablets include lactose and their derivatives, starch, cellulose derivatives. Used in the direct compression of the tablets. 3

Requirements For A Good DCV : :

Requirements For A Good DCV :  Non-toxic and acceptable to the regulatory agencies. Low cost. Physiologically inert . Must be color-compatible Stability. Controlled particle size. Good flowability. 4

What is Direct compression :

What is Direct compression Direct compression (DC) is the tabletting of a blend of ingredients i.e. the compression mix, without a preliminary granulation or aggregation process. The compression mix contains the active pharmaceutical ingredient (API) blended with one or more excipients. The excipients may include binders, fillers/diluents, disintegrant and lubricants. 5

Advantages of DC ::

Advantages of DC : More Economic compare to wet granulation since it requires fewer unit operations. Documentation and validation requirements are reduced. It requires less equipment , and space, time. lower power consumpation , and less labor leading to reduce production cost of tablets . More suitable for moisture and heat sensitive APIs , since it eliminates wetting and drying steps. Lower microbial contamination Faster drug release. 6

Disadvantages of DC ::

Disadvantages of DC : Segregation because of the difference in the density of the API and excipients. The dry state of the material during mixing may induce static charge and lead to segregation. due to this problems like weight variation and content uniformity may occur. APIs that have poor flow properties and low bulk density is difficult to process by direct compression. DC excipients are costly because these are prepared by spray drying, fluid bed drying, roller drying or co-crystallization.   7

Classification of DCV::

Classification of DCV: Disintegrants And Poor Flow: ex. Microcrystalline cellulose , Starch . Free-flowing Materials That Do Not Disintegrate : ex. Dicalcium phosphate dihydrate. Free-flowing Powders That Disintegrate By Dissolution: ex. Lactoses,Sucrose, Dextrose Sorbitol , Mannitol Co-processed exicipients : ex. Ludipress 8

Disintegrants And Poor Flow::

Disintegrants And Poor Flow: Microcrystalline cellulose: It is a purified, partially depolymerized cellulose , which is prepared by treating a-cellulose with mineral acids , producing bundles of needle-like microcrystals. It is White crystalline powder, odourless & tasteless most useful filler for direct compression. the compactibility of microcrystalline cellulose decreased with a reduction in its moisture content. 9

Disintegrants And Poor Flow::

Disintegrants And Poor Flow: Starch : Good compactability . Starch -1500 :it is a form of pregelatinized starch that has been modified to make it more compressible and flowable in character. Useful as a result of their good binding and disintegrant properties High moisture content 12-13%. Accelerate the decomposition of moisture sensitive drugs. 10

Free-flowing Materials That Do Not Disintegrate::

Free-flowing Materials That Do Not Disintegrate: Dicalcium phosphate dihydrate: Filler produced by A complicated process using phosphoric acid and slaked lime. low cost and desirable flow . Used in vitamin and mineral supplements because of the high calcium and phosphorus content. Rapidly and completely penetrated by the liquid 11

Free-flowing Powders That Disintegrate By Dissolution::

Free-flowing Powders That Disintegrate By Dissolution: Lactose : Natural disaccharide - 4.6% of cow’s milk. Lactose present in different polymorphs depending on the crystallization conditions. i.e a and b lactose . Most popular as a tablet filler . Lactose derivatives :  a-lactose monohydrate :- It is hard crystal. Non hygroscopic. Excellent physical and chemical stability. Good water solubility. Poor binding property . Good flowability 12

Free-flowing Powders That Disintegrate By Dissolution:

Free-flowing Powders That Disintegrate By Dissolution Sucrose:- Used as a filler in tablets. Used as co-crystallized sucrose with 3% modified dextrin. Good flow properties. Need glidant only above 50% relative humidity. Excellent color stability. 13

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Dextrose :- It is crystallized dextrose contains 3-5% maltose. Moisture content 9%. Available in both anhydrous and hydrous product. Highly compatible. At 75% relative humidity it becomes quite hygroscopic. Good flowability, & filler-binder 14 Free-flowing Powders That Disintegrate By Dissolution:

Free-flowing Powders That Disintegrate By Dissolution:

Free-flowing Powders That Disintegrate By Dissolution Sorbitol : Affect the compactability and stability. Moisture content 0.5-2% . Mostly used in chewable tablets. It has cool taste so used in ‘sugar free’ mints. It is hygroscopic Need of lubricant when moisture content exceeds 2% in formulation. 15

Free-flowing Powders That Disintegrate By Dissolution:

Free-flowing Powders That Disintegrate By Dissolution Mannitol :- It is used where complete solubility is required. It is costly . Used as A filler in chewable tablets . It is non-hygroscopic. It also has cooling mouth feel. Maltodextrin :- It is highly compactible. Completely soluble. Low hygroscopicity.   16

Co-processed exicipients::

Co-processed exicipients: Ludipress : It consisting of three components:a filler, a binder and a disintegrant. The exact concentrations of its constituents are stated below: 93.4% a-lactose monohydrate, 3.2% polyvinyl pyrrolidone and 3.4% crospovidone. Excellent flowability. 17

REFERENCES -:

REFERENCES - Pharmaceutical dosage forms tablet Vol-II second edition lachman leon, lieberman H.A. Page.No 77-160. www.authorstream.com 18

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Also available on Youtube! Youtube :- https://youtube.com/vishalshelke99 Instagram :- https://instagram.com/vishal_stagram

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