role of wettability, solubility & dissolution

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ROLE OF WETTABILITY , SOLUBILITY & DISSOLUTION IN DRUG DELIVERY & TARGETTING Submitted by: VISHAL SACHDEVA Seth g. l. Bihani s. d. college of technical education ( Institute of Pharmaceutical Sciences & Drug Research) Gagan path, sri Ganganagar (Raj.) 335001, india

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WETTING

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EXPLANATION

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CONTACT ANGLE

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CONTACT ANGLE Contact angle Degree of wetting Strength of: Solid/liquid interactions Liquid/liquid interactions θ = 0 Perfect wetting strong weak 0 < θ < 90° high wettability strong strong weak weak 90° ≤ θ < 180° low wettability weak strong θ = 180° perfectly non-wetting weak strong

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DETERMINATION OF WETTABILITY MICROSCOPIC OBSERVATION AMOTT MEAS UREMENTS USBM (U.S. BUREAU OF MINES) METHOD

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ROLE OF WETTABILITY EMULSIONS COSMETICS CONTACT LENSES OCCUSERTS TOPICAL DELIVERY

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SOLUBILITY

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FACTORS SOLUTE-SOLVENT RELATIONS COMMON-ION EFFECT TEMPERATURE PRESSURE

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SOLUTE – SOLVENT RELATION

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TEMPERATURE

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PRESSURE

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DISSOLUTION

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THEORIES OF DISSOLUTION DIFFUSION LAYER MODEL INTERFACIAL BARRIER MODEL DANCKWERT’S MODEL

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FACTOR AFFECTING DISSOLUTION SURFACE AREA DRUG SOLUBILITY SALT FORM CRYSTAL FORM

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THANKS