Contagious Caprine Pleuro Pneumonia

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Contagious Caprine Pleuro Pneumonia:

Contagious Caprine Pleuro Pneumonia Synonyms : CCPP, Pleuro pneumonia contagiosa, Abu Nini (Sudan)and Dey chevres LIST-B DISEASE

What is CCPP:

What is CCPP C CPP Contagious

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C C PP Caprine Affects pre dominantly Goats.

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CC P P Pleuropneumonia Pleurisy Pneumnonia

Etiology:

Etiology There is serious discrimination regarding its etiology as - Mycoplasma capricolum subsp. Capripneumoniae (was previously known as mycoplasma strain F38.) (according to Blood and Radosites book) Mycoplasma mycoides subsp. Caprae is also given as causative agent of the disease. by Amalendu chakrabarti book

Host range:

Host range Limited only to goats But atleast two international papers have reported it in ovines Doesn’t transmit to cattle Also reported in captive wild goats, Nubian ibex, Laristan mouflon and gerenuk.

Epidemiology:

Epidemiology Clinically disease is present in around 38 countries. Most of them in Asia and Africa. Reported from India . Difficult to isolate from clinical material, and hence its presence has not been confirmed in all affected countries.

Epidemiology:

Epidemiology Incubation period – 6 to 10 days . Morbidity – reaching around 100% Mortality - 60-100% So it has been included in List B of OIE.

Mode Of Transmission:

Mode Of Transmission Spread through inhalation . Bot fly can also transmit the infection.

Clinical findings (Pathology restricted to lungs only):

Clinical findings (Pathology restricted to lungs only) Highly fatal disease so cause huge mortality in flock. Anorexia Dullness Depression Nasal discharge (watery in early stage and turns mucopurulent in later stages) Frothy salivation Abdominal respiration Fever (104.5-106°F may reach up to 109°F ) Dry painful cough Tongue protrusion

Various forms Of The Disease:

Various forms Of The Disease Peracute Acute Chronic

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Peracute Death may occur within 1 to 2 days. No clinical signs

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Acute very high fever (41-43 o C [106-109 0 F]) lethargy anorexia, Violent coughing and labored respiration. Inability to move stands with its front legs wide apart neck stiff and extended. Saliva can drip continuously from the mouth the animal may grunt or bleat in pain. Frothy nasal discharge and stringy saliva may be seen terminally. Pregnant goats can abort. Acutely affected goats generally die within seven to 10 days.

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Chronic form Chronic cough Nasal discharge Debility Recovery have been reported in some experimentally infected goats It is not known whether mild disease can also occur in naturally infected animals, or if the inoculated organisms had become attenuated during culture.

Post Mortem Lesions:

Post Mortem Lesions These are limited to the respiratory system Unilateral or bilateral pneumonia Serofibrinous pleuritis with straw-colored fluid in the thorax. Cut surface of the lung is granular with copious straw-colored exudate . Pea-sized, yellow nodules may be found in the lungs. Varying degrees of lung consolidation or necrosis can be seen, The regional (bronchial) lymph nodes are enlarged. Some long-term survivors have chronic pleuropneumonia or chronic pleuritis , with encapsulation of acute lesions and numerous adhesions to the chest wall. The interlobular septa is not thickened in domesticated goats while thickening of the interlobular septa has been reported in some wild animals.

Histopathology:

Histopathology Interstitial intralobular edema is seen rather than a thickening of the interlobular septa seen with other mycoplasmal infections Sequestra are NOT seen as seen in contagious bovine pleuro pneumonia .

Diagnosis :

Diagnosis On the basis of clinical findings – severe respiratory disease high morbidity and mortality rates. The typical necropsy lesions aid diagnosis.

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On the basis of laboratory tests – Serological tests are ineffective due to cross reaction with other members of M. mycoides (although can be used as herd test) Isolation from lung tissue or pleural fluid at necropsy. Thiaucourt's medium, ' viande foie goat' (VFG), modified Hayflick's and modified Newing's tryptose . small, irregular colonies in early passage, the classic 'fried egg' colony morphology can be seen in older cultures. PCR is used as Gold standard test. M. capripneumoniae has not been found in lesions from animals with chronic disease.

Samples To Be Collected:

Samples To Be Collected Samples from active lung lesions. Pleural fluid Regional lymph nodes Tissue samples should be collected aseptically, placed in a transport medium, kept cold, and shipped to the laboratory on wet ice. Samples should be frozen if they will not reach the laboratory within a few days If necessary, samples can be stored at -20ºC for months with little apparent loss of mycoplasmal viability.

Differential Diagnosis:

Differential Diagnosis Pasteurellosis and other forms of bacterial pneumonia, Peste des petits ruminants Caseous lymphadenitis. Some other mycoplasmas, particularly Mycoplasma mycoides subsp. capri and Mycoplasma mycoides subsp. mycoides

Treatment:

Treatment Tylosin tartrate 10 mg/kg BW Oxytetracycline (15 mg/kg/d) is highly successful in limiting the severity of disease. Treated animals are still source of infection

Control:

Control Herd Biosecurity Vaccination Inactivated mycoplasma F38 Booster dose 1 month after the first vaccination Immunity is strong but generally short-lived.

Thank you:

Thank you Presented by: Vishal Thakur ( V-09-04-45)

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