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See all Premium member Presentation Transcript Slide 1: Submitted by: ARUNA VILLURI Regd.No-07AC1ROO62 Under supervision of: B.BHAVANI M.pharm,( Ph.D,) Asst.Professor VIGNAN INSTITUTE OF PHARMACEUTICAL TECHNOLOGY (Approved by AICTE & Affiliated to JNTU) Beside VSEZ, Duvvada, Vadlapudi (P.O.), Gajuwaka, Visakhapatnam-530046 Fast Dissolving Drug Delivery Systems CONTENTS : CONTENTS Introduction Advantages Disadvantages Method of preparation Patented technologies Evaluation Marketed products Development of technology Conclusion References Slide 3: Introduction A fast-dissolving drug delivery system, in most cases, is a tablet that dissolves or disintrigrants in the oral cavity without the need of water or chewing. Most fast-dissolving delivery system films must include substances to mask the taste of the active ingredient. This masked active ingredient is then swallowed by the patient's saliva along with the soluble and insoluble excipients Advantages Patient’s compliance for disabled elderly patients and for travelling and busy People who do not have ready access to water. A middle-aged woman undergoing radiation therapy for breast cancer may be too nauseous to swallow her H2-blocker. Fast-dissolving/disintegrating tablets (FDDTs) are a perfect fit for all of these patients A schizophrenic patient in the institutional setting can hide a conventional tablet under his or her tongue to avoid their daily dose of an atypical antipsychotic. Slide 4: Disadvantages It is hygroscopic in nature so must be keep in dry place. Sometime it possesses mouth feeling. It is also show the fragile, effervesces granules property. FDDS requires special packaging for properly stabilization & safety of stable product. Method of preparation Freeze drying or Lyophilization Molding Spray drying Sublimation Direct compression Taste masking Any pre-gastric absorption avoids first-pass metabolism and can be an advantage in drugs that undergo a great deal of hepatic metabolism. Slide 5: Freeze drying Drying of heat sensitive drugs+Biological low temperature remove water by sublimation Lyophilization :- preparation Highly porous very high specific surface area dissolve rapidly improved absorption &bioavailability Slide 6: Molding :- Manufacturing process Moister the power + hydro alcoholic Wet mass is placed in mold plates Solvent is removed by air drying Less compact ;porous structure ;Fast dissolution Heat molding process Suspension contain drug, agar, sugar Pour suspension blister packing well as a mold Solidification agar solution at room temperature to form jelly Slide 7: Spray drying : Hydrolyzed and unhydrolyzed gelatin Mannitol as a bulking agent Sodium starch glycolate or crosscarmellose as adisintegrant. Disintegration and dissolution was further enhance adding acid (e.g., citric acid) or an alkali (e.g.,sodium bicarbonate) Sublimation: Highly water soluble ingredients Fall to dissolve rapidly & low porosity matrix volatile ingredients Sublimation Remove of volatile material, leaving behind porous matrix; Increases dissolution Slide 8: Direct compresion : Addition of disintegration Superdisintegrants -eg:-cross povidone Capillary action - eg:-microcrystalline cellulose Absorbing agents – eg:- agra power Sugar –based excipients :- eg;- dextrose , fructose, maltose, sorbitol Taste masking :- Microencapsulation:-to avoid bitter drug add acrylic polymers these are evaporated by solvent extraction techniques (Eudragit E,L-55& RL)when it coated with water insoluble polymer (EC,HMC)dissolution increases. sparofloxacin is a bitter drug when add low HPC to drug core &increases dissloution rate ,bioavaliablity Coacervation Macrolides Microcapsules Slide 9: Evalution General appearance Tablet thickness Weight variation Tablet hardness Tablet friability Tablet Disintegration Wetting time Tablet dispersion time Marketed products Zydis products: Zofran ODT –Ovidansetron – 5HT blocker Zyprexa Zydis –Olanzapine –anxolities Pepcid RPD – Famotidine-H2 blocker Orasol products Remeron soltab –Mirtazepine-anxolities Tempra first tab –Acetamino phen triaminic soft chew (OTC) Durasolv products: Nulev –Hyoscyamine sulfate Zomig ZMT-Zolmitriptan Wow tab produts: Benadry allergy & sinus fast melt (OTC) Childern’s Benadry allergy & cold fast melt Slide 10: In the year 1995 H.SEAGAR studied new FDDS and studied form and process technology of ZYDIS In the year 2000 PAPA.G & GRAFITANU E. studied FDDS as a new modern soiled dosage form and process technology of DIRECT COMPRESSION In the year 2000 FU.Y & PARK.K studied the application of polyacrylic super porous hydrogen microparticals as a super disintegrant in FDDS and process technology is DIRECT TECHNOLOGY I n the year 2003 VAN SCHAICK ET .AL did the pharmacokinetic comparision of FDDS of Resperidon In the year 2004 ABU LZZA ET AL patented a technology of making FDDS CIRRI M . & MURA P. developed FDDS of Glyburide based on ternary solid dispersion with PE-6000 and surfactants. P.D. CHOWDARY ET AL lated FDDS of Famotidi In the year 2006 proved to be the FDDS SAMMOUR O .A ; HAMMAAD M. A ; MEGRAD N .A ; Zidan A. S carried out the formulation. Development of technology Slide 11: Conclusion Pharmacists are in an ideal position to become familiar with different technologies and education their patients about different dosage regimens Patients may be surprised when a tablet begin to dissolve in the mouth . patients may expel it unknowingly &They might expect faster onset of therapeutic action Hence, patient demand and the availability of various technologies have increased the market share of Fast dissolving tablets, which in turn prolongs the patent life of a drug. Keeping in view of the advantages of the delivery system, rapidly disintegrating dosage forms have been successfully commercialized, and because of increased patient demand, these dosage forms are expected to become more popular. You do not have the permission to view this presentation. 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fast dissolving drug delivery system villuri Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 867 Category: Education License: All Rights Reserved Like it (2) Dislike it (0) Added: August 13, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... By: krishnabhe (11 month(s) ago) plz send ppt on my e mail Saving..... Post Reply Close Saving..... Edit Comment Close By: naresh.choudhary38 (12 month(s) ago) plz send me copy of it on naresh.choudhary38@gmail.com Saving..... Post Reply Close Saving..... 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See all Premium member Presentation Transcript Slide 1: Submitted by: ARUNA VILLURI Regd.No-07AC1ROO62 Under supervision of: B.BHAVANI M.pharm,( Ph.D,) Asst.Professor VIGNAN INSTITUTE OF PHARMACEUTICAL TECHNOLOGY (Approved by AICTE & Affiliated to JNTU) Beside VSEZ, Duvvada, Vadlapudi (P.O.), Gajuwaka, Visakhapatnam-530046 Fast Dissolving Drug Delivery Systems CONTENTS : CONTENTS Introduction Advantages Disadvantages Method of preparation Patented technologies Evaluation Marketed products Development of technology Conclusion References Slide 3: Introduction A fast-dissolving drug delivery system, in most cases, is a tablet that dissolves or disintrigrants in the oral cavity without the need of water or chewing. Most fast-dissolving delivery system films must include substances to mask the taste of the active ingredient. This masked active ingredient is then swallowed by the patient's saliva along with the soluble and insoluble excipients Advantages Patient’s compliance for disabled elderly patients and for travelling and busy People who do not have ready access to water. A middle-aged woman undergoing radiation therapy for breast cancer may be too nauseous to swallow her H2-blocker. Fast-dissolving/disintegrating tablets (FDDTs) are a perfect fit for all of these patients A schizophrenic patient in the institutional setting can hide a conventional tablet under his or her tongue to avoid their daily dose of an atypical antipsychotic. Slide 4: Disadvantages It is hygroscopic in nature so must be keep in dry place. Sometime it possesses mouth feeling. It is also show the fragile, effervesces granules property. FDDS requires special packaging for properly stabilization & safety of stable product. Method of preparation Freeze drying or Lyophilization Molding Spray drying Sublimation Direct compression Taste masking Any pre-gastric absorption avoids first-pass metabolism and can be an advantage in drugs that undergo a great deal of hepatic metabolism. Slide 5: Freeze drying Drying of heat sensitive drugs+Biological low temperature remove water by sublimation Lyophilization :- preparation Highly porous very high specific surface area dissolve rapidly improved absorption &bioavailability Slide 6: Molding :- Manufacturing process Moister the power + hydro alcoholic Wet mass is placed in mold plates Solvent is removed by air drying Less compact ;porous structure ;Fast dissolution Heat molding process Suspension contain drug, agar, sugar Pour suspension blister packing well as a mold Solidification agar solution at room temperature to form jelly Slide 7: Spray drying : Hydrolyzed and unhydrolyzed gelatin Mannitol as a bulking agent Sodium starch glycolate or crosscarmellose as adisintegrant. Disintegration and dissolution was further enhance adding acid (e.g., citric acid) or an alkali (e.g.,sodium bicarbonate) Sublimation: Highly water soluble ingredients Fall to dissolve rapidly & low porosity matrix volatile ingredients Sublimation Remove of volatile material, leaving behind porous matrix; Increases dissolution Slide 8: Direct compresion : Addition of disintegration Superdisintegrants -eg:-cross povidone Capillary action - eg:-microcrystalline cellulose Absorbing agents – eg:- agra power Sugar –based excipients :- eg;- dextrose , fructose, maltose, sorbitol Taste masking :- Microencapsulation:-to avoid bitter drug add acrylic polymers these are evaporated by solvent extraction techniques (Eudragit E,L-55& RL)when it coated with water insoluble polymer (EC,HMC)dissolution increases. sparofloxacin is a bitter drug when add low HPC to drug core &increases dissloution rate ,bioavaliablity Coacervation Macrolides Microcapsules Slide 9: Evalution General appearance Tablet thickness Weight variation Tablet hardness Tablet friability Tablet Disintegration Wetting time Tablet dispersion time Marketed products Zydis products: Zofran ODT –Ovidansetron – 5HT blocker Zyprexa Zydis –Olanzapine –anxolities Pepcid RPD – Famotidine-H2 blocker Orasol products Remeron soltab –Mirtazepine-anxolities Tempra first tab –Acetamino phen triaminic soft chew (OTC) Durasolv products: Nulev –Hyoscyamine sulfate Zomig ZMT-Zolmitriptan Wow tab produts: Benadry allergy & sinus fast melt (OTC) Childern’s Benadry allergy & cold fast melt Slide 10: In the year 1995 H.SEAGAR studied new FDDS and studied form and process technology of ZYDIS In the year 2000 PAPA.G & GRAFITANU E. studied FDDS as a new modern soiled dosage form and process technology of DIRECT COMPRESSION In the year 2000 FU.Y & PARK.K studied the application of polyacrylic super porous hydrogen microparticals as a super disintegrant in FDDS and process technology is DIRECT TECHNOLOGY I n the year 2003 VAN SCHAICK ET .AL did the pharmacokinetic comparision of FDDS of Resperidon In the year 2004 ABU LZZA ET AL patented a technology of making FDDS CIRRI M . & MURA P. developed FDDS of Glyburide based on ternary solid dispersion with PE-6000 and surfactants. P.D. CHOWDARY ET AL lated FDDS of Famotidi In the year 2006 proved to be the FDDS SAMMOUR O .A ; HAMMAAD M. A ; MEGRAD N .A ; Zidan A. S carried out the formulation. Development of technology Slide 11: Conclusion Pharmacists are in an ideal position to become familiar with different technologies and education their patients about different dosage regimens Patients may be surprised when a tablet begin to dissolve in the mouth . patients may expel it unknowingly &They might expect faster onset of therapeutic action Hence, patient demand and the availability of various technologies have increased the market share of Fast dissolving tablets, which in turn prolongs the patent life of a drug. Keeping in view of the advantages of the delivery system, rapidly disintegrating dosage forms have been successfully commercialized, and because of increased patient demand, these dosage forms are expected to become more popular.