Disintegration .

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Disintegration :

Disintegration implies penetration of the tablet by an aqueous liquid, disruption of internal bonds and the subsequent break down of tablet. Rapid penetration of liquid is an essential requirement for rapid disintegration of conveniently formulated tablets. Disintegration

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Effect of granule properties :

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Hardness and bulk density increases with amount of water used for granulation due to reduction in intragranule pore volume. Rapid penetration of the wider pores isolated some region of the compact, occluded air prevented subsequent penetration of the isolated regions and as a result, a lower than theoretical degree of saturation was attained.

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Geometry of the compact demands a reduction in the total pore cross sectional area available for the of liquid to the center of tablet. Liquid will penetrate until the increase in pressure of the occluded air is equal to the capillary pressure.

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Effect of die wall lubricants:

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When 1% of Mg. stearate was incorporated during the moist granulation, the penetration of water was completely inhibited. The pores were so well coated that the contact angle was greater than 90*. As the Cosine of an angle greater than 90* is (-ve), the volume of liquid in the pores (V)is also (-ve) and penetration of liquid cannot occur.

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Mode of disintegrate action : Starch has been used for many decades as disintegrating agent. Compression ratio is the ratio of the weight of a tablet to its thickness, as a measure of the degree of compaction in their studies. the disintegration time of tablets containing 15%of starch, dry mixed with phenacetin granules. C . R is 0.57 = 15 min C . R is 0.7 = 6 min C .R is 0.75 = 24 min

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Disintegrates facilitates tablet disintegration by swelling action is based on the known increase in the dimensions of starch grains exposed to aqueous fluids. Disintegrates also derive its disintegration property from capillary action in the intergranule pore system. Capillary action also prevent the complete collapse of the pore system during compaction.

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Disintegration time of tablets is effected by the complex interaction of a wide variety of factors. Rate at which liquid penetrates a tablet. Nature and method of incorporation of lubricants. Action of disintegrates. Degree of compaction. The reduction of inter-particle bond strength in the presence of water.

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