KIRANS SWINE FLU final

Views:
 
Category: Education
     
 

Presentation Description

No description available.

Comments

By: rahulnakra (107 month(s) ago)

very nice presentation can i download it thanks dr rahul

By: titanicman785 (109 month(s) ago)

very thankful to u.can i have ur ppt.thanks kiran.

By: mohamadobedat (112 month(s) ago)

Thank you very much for a nice PPT on swineflu. If you can send me a copy of the same to my email address, I will remain grateful to you. I have been associated with teaching and training viral diseases. With thanks

By: rrmtexas (115 month(s) ago)

can i copy ur ppt in Ah1n1 for my public lecture? this is my email add: rrmtexas@yahoo.com. Please help thanks.

By: sairidhi (116 month(s) ago)

Very good presentation. please could you allow me to down load tour presentation. Thanks roshini

See all

Presentation Transcript

INFLUENZA A (H1N1) : 

INFLUENZA A (H1N1) SPEAKER DR. KIRAN PATIL 2ND YR POST GRADUATE G.S.V.M. MEDICINE DEPTT. KANPUR. MODERATOR DR.B.P.PRIYADARSHI ASST.PROFFESSOR G.S.V.M. MEDICINE DEPTT. KANPUR.

What is Swine Flu : 

What is Swine Flu Swine influenza virus (referred to as SIV) refers to influenza cases that are caused by Orthomyxovirus endemic to pig populations. SIV strains isolated to date have been classified either as Influenza(virus C or one of the various subtypes of the genus Influenza virus A)

QUADRUPLE REASSORTMENT GENETICS : 

QUADRUPLE REASSORTMENT GENETICS Human swine SHIFT Avian swine H1N1

INFLUENZA VIRUS : 

INFLUENZA VIRUS

TYPES : 

TYPES

PIG THE CREATOR : 

PIG THE CREATOR

VIRAL VARIANTS : 

VIRAL VARIANTS INFLUENZA A VIRUS Swine Human Avian H1N2 H1N1(pandemics) H5N1 H3N1 H3N2 (rare) H3N2

EPIDEMIOLOGY : 

EPIDEMIOLOGY Incubation period- 1-7 days Transmission PRIMARY CASE –direct contact with pigs SECONDARY CASES sneezing, coughing resp droplets body fluids(diarroeal stool) contact surfaces

Slide 9: 

This virus is not transmitted from eating pork or pork products Contagiousness: 1 day onset of symptoms 7 days Children are contagious for longer periods. . Majority of pts were previously healthy. Clinical course mild in PCR negative influenza.

Risk factors : 

Risk factors COPD Immunocompromised state DM Pregnancy Cardiac disease Obesity CHF ,Renal failure,hepatic failure Children <5 yrs, elder>65 yrs. Cancer.

DEFINITIONS : 

DEFINITIONS Influenza-like illness (ILI) is defined as fever (temperature of 100ºF [37.8ºC] or greater) with cough or sore throat in the absence of a known cause other than influenza

Case Definitions By CDC : 

Case Definitions By CDC A confirmed case acute febrile respiratory illness with laboratory-confirmed H1N1 influenza A virus detection by real-time reverse transcriptase (RT)-PCR or culture. A probable case acute febrile respiratory illness who is positive for influenza A, but negative for H1 and H3 by RT-PCR

Slide 13: 

A suspected case acute febrile respiratory illness who:       - Develops symptoms within seven days of close contact with a person who is a confirmed case of H1N1 influenza A virus infection or       - Develops symptoms within seven days of travel or resides in a community where there are one or more confirmed H1N1 influenza A cases

CLINICAL FEATURES : 

CLINICAL FEATURES Vomiting or diarrhea (not typical for influenza but reported by recent cases of swine influenza infection)

Other Manifestations: : 

Other Manifestations: Tachycardia Tachypnoea Low O2 sat. Hypotension Cyanosis Acute myocarditis Cardiopulmonary arrest

H1 N1 Pneumonia : 

H1 N1 Pneumonia

COMPLICATIONS : 

COMPLICATIONS Similar to those of seasonal influenza Exacerbation of underlying chronic medical conditions Upper respiratory tract disease (sinusitis, otitis media, croup) Lower respiratory tract disease (pneumonia, bronchiolitis, status asthmaticus)

Slide 18: 

Cardiac (myocarditis, pericarditis) Neurologic (Acute and post-infectious encephalopathy, encephalitis, febrile seizures, status epilepticus) Toxic shock syndrome Secondary bacterial pneumonia with or without sepsis

Children Emergency Warning Signs : 

Children Emergency Warning Signs Fast breathing or trouble breathing Bluish or gray skin color Not drinking enough fluids Severe or persistent vomiting Not waking up or not interacting Being so irritable that the child does not want to be held Flu-like symptoms improve but then return with fever and worse cough

In adults, emergency warning signs : 

In adults, emergency warning signs Difficulty breathing or shortness of breath Pain or pressure in the chest or abdomen Sudden dizziness Confusion Severe or persistent vomiting Flu-like symptoms improve but then return with fever and worse cough

CATEGORISATION 14/8/09 : 

CATEGORISATION 14/8/09 CATEGORY -A: Mild fever plus sore throat /cough with or without bodyache, headache,diarrohea/ vomiting. CATEGORY-B(i) : A+ High grade fever and severe sore throat. B (ii) :A + HIGH RISK GROUPS.

CATEGORISATION 14/8/09 : 

CATEGORISATION 14/8/09 CATEGORY C: A/B + 1/MORE OF THE FOLLOWING Breathlessness,chest pain,drowiseness,hypotension,cynosis,irritability or worsening of the existing chronic condition.

COMPARISION : 

COMPARISION

contd : 

contd

DIAGNOSTIC TESTS : 

DIAGNOSTIC TESTS

LABORATORY FINDINGS : 

LABORATORY FINDINGS CBC- leucocytosis/leucopenia lymphopenia Elevated CPK, LDH Elevated UREA,CREATININE Elevated AST,ALT CHEST RADIOGRAPH-bilateral patchy pneumonia.

INVESTIGATIONS-Specimens : 

INVESTIGATIONS-Specimens Nasopharyngeal swab, nasal swab, throat swab, combined oropharyngeal/ nasopharyngeal swab, or nasal aspirate Swabs with a synthetic tip (eg, polyester or Dacron) and an aluminum or plastic shaft should be used. Swabs with cotton tips and wooden shafts are not recommended. The collection vial in which the swab is placed should contain 1 to 3 mL of viral transport media.

Slide 29: 

Respiratory specimen should be collected within 4 to 5 days of illness. Specimens should be placed in viral transport media and placed on ice (4ºC) or refrigerated immediately for transportation to the laboratory

LAB TESTS : 

LAB TESTS Real time RT PCR-confirmatory culture is usually too slow to help guide clinical management. A negative viral culture does not exclude pandemic H1N1 influenza A infection. Rapid antigen tests — evaluation of patients suspected of having influenza, but results should be interpreted with caution the QuickVue Influenza A+B (Quidel) assay (sensitivity 51 percent specificity 99 percent)

Slide 31: 

Rapid influenza antigen tests & Direct or indirect immunofluorescent antibody testing (DFA or IFA) can distinguish between influenza A and B but negative test does not exclude infection.

TREATMENT : 

TREATMENT Only neuraminidase inhibitors ORALTamiflu (oseltamivir) and Relenza( zanamivir) are approved to cure the viral infection. H1N1 is resistant to Amantadine Rimantadine Antiviral drugs can be given to treat those who become severely ill with influenza.

Tamiflu (Oseltamivir ) : 

Tamiflu (Oseltamivir ) Block the active site of the influenza viral enzyme neuraminidase This effect results in viral aggregation at the host cell surface and reduces the number of viruses released from the infected cell

Tamiflu : 

Tamiflu

Tamiflu : 

Tamiflu

Tamiflu(contd) : 

Tamiflu(contd) If one dose missed? take as soon as you remember unless it is within 2 hours of next dose do not take two doses at a time . With other medications? minimal drug interaction no intranasal flu vaccine(Flu Mist) within 2weeks before or 48 after taking tamiflu

Tamiflu (Contd) : 

Tamiflu (Contd) With kidney disease Flu treatment :one 75mg dose OD for 5 days Flu prevention:one 75 mg dose alternate day or 30 mg dose OD . Storage: capsules- <25 degree C liquid - 2 to 8 degree C

Tamiflu(Cont) : 

Tamiflu(Cont) Side effects: GI ,occasionally bronchitis ..insomnia..vertigo,angina,pseudomembranous colitis,peritonsilar abscess. Price-2250 for 10 tabs.

Zanamivir ( Relenza) : 

Zanamivir ( Relenza) It is not recommended for people with underlying respiratory disease such as asthma or chronic obstructive pulmonary disease or lactose intolerance Treatment of 7 year & older patients 10mg (2puffs)BID 5d Prophylaxis of 5 year & older patients 10mg OD 10d-28 days Status in India

Hand washing : 

Hand washing

N95 Mask : 

N95 Mask

What should I do to keep from getting the flu? : 

What should I do to keep from getting the flu? First and most important: wash your hands Get plenty of sleep Drink plenty of fluids Try not to touch surfaces that may be contaminated with the flu virus. Avoid close contact with people who are sick.

Avoid close contact : 

Avoid close contact Avoid close contact with people who are sick. When you are sick, keep your distance ( > 1 meter )from others to protect them from getting sick too. Aerosols spread the virus in any environment

N95 RESPIRATORS : 

N95 RESPIRATORS

Prevention : 

Prevention management of the outbreak such as closure of schools, advising avoidance of mass gatherings and distribution of antivirals Avoiding close contact Staying home from work, school Covering mouth and nose with a tissue or N95 mask (three layered) when coughing or sneezing. Change the mask every 6 to 8 hours Washing your hands

Why do we need vaccine : 

Why do we need vaccine

Conclusion : 

Conclusion Be cautious but no need to panic Need for further guidelines beyond diagnosis & management. Judicious use of diagnostic tests Early suspecting and treating cytokine storm is very important Not to forget universal precautions

authorStream Live Help