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Blood:

Blood

Blood:

Blood Blood is not an epithelial tissue, and it’s not loose or dense connective tissue; it’s classified as a “special connective tissue”. You have about 5 liters of blood, but that is only half of the body fluid. The other half includes fluid around each cell, and joint fluids, etc.

Blood:

Blood PLASMA  EXTRACELLULAR FLUID ↑ ↓ SYNOVIAL FLUIDS, ETC

Blood consists of the following::

Blood consists of the following: Plasma Red blood cells White blood cells Platelets

FUN FACTS:

FUN FACTS In one day, your blood travels nearly 12,000 miles. Your heart beats around 35 million times per year. Your heart pumps a million barrels of blood during the average lifetime -- enough to fill three supertankers. If an artery is cut, blood will shoot out 30 feet.

Plasma:

Plasma Plasma is what the blood cells float around in. If you spin a blood sample in a test tube, the red blood cells sink to the bottom, and you’ll see the yellow plasma on top. Some people who need blood just need the packed RBCs, some need the platelets, others need the plasma, and some need whole blood, which is both plasma and RBCs. The plasma also carries around the platelets and some white blood cells.

Overview: Composition of Blood:

Overview: Composition of Blood Figure 17.1

PLASMA CONTENTS :

PLASMA CONTENTS Water (90%) Dissolved substances (10%) Proteins Albumin (egg white). Most common protein in blood (homeostasis) Antibodies Clotting factors called fibrinogen and fibrin. Lipoproteins (move fats through blood: HDL , LDL) Nutrients Glucose (main energy source) Amino Acids (builds proteins) Wastes (urea) Gases (O2, CO2, Nitrogen) Electrolytes = ions (Na+, K+, Cl-, Ca++)

Blood Cells:

Blood Cells

ERYTHROCYTES (Red blood cells):

ERYTHROCYTES (Red blood cells) 5 million Like a doughnut with the hole not fully cut out. These are among the smallest cells in the body They have no nucleus Biconcave to increase surface area Filled with hemoglobin ( Hgb ), which carries O2 throughout the body. Oxygenated Hgb is bright red, deoxy Hgb is deeper red, almost a bluish-purple.

Slide 13:

Erythrocytes

Hemoglobin Molecule:

Hemoglobin Molecule

Hemoglobin Molecule:

Hemoglobin Molecule

ERYTHROCYTES::

ERYTHROCYTES: Average life span is 120 days. Old ones are destroyed in the spleen and liver, and Hgb is recycled. During your lifetime, about 250 billion of these cells are destroyed, and 250 billion are made: where? Red marrow.

Microbiology:

Microbiology To understand the function of white blood cells, you will need to learn some general concepts and terminology from Microbiology: Pathogen General size of bacteria and viruses Antigen

Pathogen “Path” = disease “ogen” = generating:

Pathogen “Path” = disease “ ogen ” = generating A pathogen is something that causes disease. A biological pathogen is a bacterium, virus, fungi, yeast, protozoa, worms, etc. A non-biological pathogen can be a toxic chemical, asbestos, etc. Usually, the term “pathogen” refers to a biological pathogen.

Sizes of Pathogens:

Sizes of Pathogens Bacteria are so small that hundreds of them can fit inside one white blood cell. However, bacteria usually do not invade body cells. They live between the cells of the body, using up nutrients in the area, and they cause harm by secreting toxins. Viruses are so small that thousands of them can fit inside the NUCLEUS of one white blood cell. They always try to invade body cells because they need a piece of our DNA or RNA in order to replicate. When a body cell has been invaded by a virus, the entire cell must be killed by a white blood cell.

Antigen:

Antigen An antigen is anything that causes an immune response, which isn't necessarily a biological pathogen (disease-causing organism). A non-biological antigen can be pollen, dust, grass, or anything that a person is allergic to. Pollen can be an antigen to a person with allergies, but it is not an antigen to a person without allergies, because no immune response was launched.

LEUKOCYTES (White blood cells) all fight infection:

LEUKOCYTES (White blood cells) all fight infection BASOPHILS MAST CELL EOSINOPHILS NEUTROPHILS MONOCYTES MACROPHAGES LYMPHOCYTES B CELLS T CELLS

BASOPHILS:

Basophils – only about 0.5% of all leukocytes Granules secrete histamines ( vasodilation ; more WBCs can get to the infection site) Antihistamines interfere with the function of basophils . Mast Cell: a basophil that leaves the blood vessel and enters the tissues. BASOPHILS

Eosinophils:

Eosinophils Eosinophils – compose 1-4% of all WBCs Play roles in: Ending allergic reactions , parasitic infections During these conditions they increase in numbers

Neutrophils:

Neutrophils – most numerous WBC First to respond to infection Phagocytize and destroy bacteria Also destroy bacterial toxins in body fluids Nucleus – has two to six lobes Neutrophils

Neutrophils:

Neutrophils Neutrophils are the white blood cells that contribute to immunity mainly by engulfing BACTERIA and foreign bodies (thorns, dirt, etc) in a process called phagocytosis. They release the contents of their lysosomes onto the invader, dissolving it. When a bacterium has a capsule, it makes it hard to phagocytize, so the neutrophil requires opsonization by antibodies.

Opsonization:

Opsonization Some bacteria have evolved a slippery capsule around them as a defense against phagocytosis. The neutrophil cannot engulf this type of bacteria. Neither can a macrophage. When an antibody attaches to this type of bacteria, the neutrophil can now grab onto the antibody like a handle, enabling it to phagocytize the bacteria. This process of facilitation of phagocytosis is called opsonization .

Slide 30:

When an invading bacteria has the antibody attached to its cell membrane, the entire structure is now called an antigen-antibody complex. If a bacterium does not have a capsule, the neutrophil can destroy it without opsonization . The antibody can also destroy the bacterium by itself by popping the cell membrane. But when a capsule is present, the neutrophil and antibody work best together. Neutrophils are also the ones that primarily destroy the dissolved toxins that bacteria secrete into body fluids.

Monocytes:

Monocytes Comprise about 5% of all WBC’s. Like neutrophils, they phagocytize (eat) bacteria, old cells, and foreign bodies. They have more types of lysosome enzymes than neutrophils so they are better at killing difficult pathogens. They also use antibodies for opsonization . When they leave the bloodstream and enter the tissues, they are called MACROPHAGES.

WBC’s leave the blood vessel to enter the tissues:

WBC’s leave the blood vessel to enter the tissues

What’s the Difference between Neutrophils and Monocytes/Macrophages?:

What’s the Difference between Neutrophils and Monocytes /Macrophages? There are 10x more neutrophils in the bloodstream than monocytes/Macrophages. Consider neutrophils to be the most numerous white blood cell. However, there are more macrophages in the tissues of the body. They are everywhere! Neutrophils live only a few days. Monocytes/Macrophages live a few months. Lymphocytes live for years. Monocytes/Macrophages are larger and slower than neutrophils, but they can phagocytize larger organisms and more of them. Neutrophils usually just phagocytize bacteria until they die. Macrophages phagocytize and then take pieces of the dead bacteria and present them to lymphocytes so a larger immune response can occur.

Differences in Function:

Differences in Function There are two types of phagocytes: Neutrophils and macrophages. Neutrophils and macrophages both mainly function by phagocytizing bacteria (not viruses). Lymphocytes are mostly needed to kill off body cells infected by viruses.

Differences in Function:

Differences in Function Neutrophils just phagocytize bacteria and secrete chemicals to recruit more white blood cells to the site. Unlike neutrophils, macrophages have surface receptors ; these "recognize" the surface of the pathogen’s cell membrane. Macrophages phagocytize the bacteria, pop their lysosomes onto it, and dissolve it, except for some pieces of the bacteria’s cell membrane. The macrophage places these pieces of bacteria on its own cell membrane, and finds a lymphocyte to present it to.

Differences in Function:

Differences in Function Macrophages present these pieces to T cell lymphocytes and to B cells lymphocytes. The lymphocyte feels the shape of the bacteria pieces on top of the macrophage, (this is called “antigen presentation”) and the lymphocyte can then launch an attack on the rest of the bacteria still alive in the body. In this way, the macrophage recruits even more lymphocytes to join the war. So, what is a lymphocyte?

Lymphocytes:

20–45% of WBCs The most important cells of the immune system There are two types of lymphocytes; one type is effective in fighting infectious organisms like body cells infected with viruses Both types of lymphocytes act against a specific foreign molecule (antigen) Lymphocytes

Lymphocytes:

Two main classes of lymphocyte B cells – Originate in the bone marrow, mature into plasma cells. A mature plasma cell fights infection by producing antibodies T cells – Originate in the thymus gland. They attack foreign cells directly ( including organ transplants!). They can also kill viruses. Lymphocytes

Lymphocytes:

B cells – mature into plasma cells Plasma cells secrete antibodies; the plasma cell’s antibodies are what kills the attacking cell. Antibodies attack in two ways: They attach to bacteria and pop the cell membrane They attach to encapsulated bacteria to help neutrophils and macrophages to phagocytize them. Lymphocytes

Disorder of B-cell Lymphocytes:

Mononucleosis : Epstein Barr virus attacks B lymphocytes. It is characterized by inflammation of lymph vessels ( lymphangitis ). Lymphangitis : lymph vessel inflammation; usually from infection. Infected lymphocytes have a characteristic scalloped edge where they touch RBC’s Disorder of B-cell Lymphocytes

Function of a B Lymphocyte:

Function of a B Lymphocyte Figure 17.6b

T-cell Lymphocytes:

T cells – coordinate the immune response by recruiting other white blood cells. They can directly destroy bacteria by popping their cell membrane. T cells can also directly destroy foreign cells by popping the cell membrane. They do not need to phagocytize the invading cell. They do not need the assistance of antibodies. T-cells can therefore kill a body cell that has become infected with viruses. T-cell Lymphocytes

T-Cell:

T-Cell

T-cell Lymphocytes:

T cells are the cells that attack organ transplants! Immunosuppression drugs are designed to inhibit the action of T cells. T cells are attacked by the HIV (AIDS) virus. The thymus gland secrets certain hormones which can cause T cells to become immunocompetent (makes the cells mature and start to work) T-cell Lymphocytes

T Cells:

T Cells There are several types of T cells. The main types are Cytotoxic (Killer) T cells Go out and directly kill bacteria or infected host cells Helper T cells Release chemicals called “cytokines” to stimulate the plasma cells to produce antibodies against the bacteria. Cytokines also call in more white blood cells of all types to join in the war. Suppressor T cells Stop the immune process when it is over, and also "tell" some plasma cells to "remember" how to destroy that specific pathogen. Those plasma B-cells are then called Memory B-Cells. They can react to the same pathogen faster, the next time it invades because Memory B-cells already have the proper antibodies stored up for that pathogen.

Killer T-Cell:

Killer T-Cell

Virus-Infected Cell:

Virus-Infected Cell

Function of a T- Lymphocyte:

Function of a T- Lymphocyte Figure 17.6a

Summary:

Summary A pathogen somehow gets past the body's physical and chemical barriers and the inflammation response. The pathogen is engulfed by a macrophage (or neutrophil ). The macrophage releases the contents of its lysosomes onto the bacterium and dissolves most of it. There are still some pieces of the bacterium’s cell membrane left. The macrophage then forces the surface proteins of the bacterium (antigens) to it's own cell surface. Helper T-Cells touch these surface antigens, make a copy of their shape, and present them to B-cells to make antibodies against them.

Summary:

Summary These Helper T-Cells begin to multiply and have two main roles. The first is to activate B-Cells and "tell" them how to neutralize the pathogen by presenting the pieces of the bacterium cell membrane so the B-cells can turn into plasma cells which make the antibodies. The B-Cells (now called Plasma cells because they have been activated) begin to multiply and produce the antibodies to neutralize this specific pathogen. The second role of Helper T-Cells is to activate the Killer T-Cells by secreting cytokines. Killer T-Cells can either destroy the pathogen itself (bacteria), or destroy the entire body cell which is infected (viruses). When the immune response is over, Suppressor T-Cells stop the process and also "tell" some B-Cells (plasma cells) to "remember" how to destroy that specific pathogen. Those B-cells (plasma cells) now become Memory B-Cells.

Antibodies:

Antibodies Antibodies (also known as immunoglobulins , abbreviated Ig ) are proteins made by plasma cells. They are used to identify and neutralize foreign objects, such as bacteria and viruses. They are typically made of basic structural units—each with two large heavy chains and two small light chains—to form a unit shaped like the letter “Y”

A Typical Antibody:

A Typical Antibody The tips of the “Y” have receptors that are specific for a particular antigen. The stem of the “Y” can be grasped by a phagocyte.

Antibodies:

Antibodies The small region at the tip of the protein is extremely variable, allowing millions of antibodies with slightly different tip structures, or antigen binding sites, to exist. This region is known as the hypervariable region. Each of these variants can bind to a different target, known as an antigen. This huge diversity of antibodies allows the immune system to recognize an equally wide diversity of antigens.

Antibodies:

Antibodies Some of these “Y” shaped units exist by themselves (monomers) Some are in pairs (dimers) Some are in a cluster of five (pentamers) There are five different antibody types , which perform different roles, and help direct the appropriate immune response for each different type of foreign object they encounter.

Types of Antibodies:

Types of Antibodies

Slide 56:

Neutrophil Macrophage (Monocyte in bloodstream) B-Cell Killer T-Cell Helper T-Cell Suppressor T-Cell Plasma Cell Lymphocytes Phagocytosis Bacteria Virus Presentation Y Y Y Antibodies Y Y Pops the cell Capsule Cytokines Pops the cell STOP Opsonization Bacteria Presentation

IMMUNITY:

IMMUNITY B Cells that have matured into plasma cells which have made antibodies are now called Memory lymphocytes, after their first war. Most people are sick more often as children than as adults in their 20s through 30s because we build up many varieties of memory lymphocytes during childhood, providing immunity from more and more antigens during adulthood.

Myasthenia gravis:

Myasthenia gravis Myasthenia gravis (MG): autoimmune disease where antibodies destroy or block receptors for acetylcholine, a neurotransmitter. Causes muscle paralysis. First attacks small muscles especially those that keep eyes open; will spread to diaphragm  death. To stave off effects, do thymectomy .

PLATELETS:

PLATELETS Very small compared to all other blood cells. These are pieces of another cell found in the red marrow called a MEGAKARYOCYTE. Pieces break off of a megakaryocte and are known as platelets. When a platelet encounters a broken blood vessel it releases a substance that clots blood. Platelets are responsible for clot formation .

Platelets:

Platelets Platelets need certain proteins in the plasma called CLOTTING FACTORS in order for them to become activated and form a clot. Two main clotting factors are called FIBRIN and FIBRINOGEN.

Platelets:

Platelets Cell fragments Break off from megakaryocytes Function in clotting of blood Megakaryocyte Platelets

Slide 62:

Blood Clot

Summary of Formed Elements:

Summary of Formed Elements Table 17.1 (1)

Summary of Formed Elements:

Summary of Formed Elements Table 17.1 (2)

Life span, from longest-lived to shortest-lived::

Life span, from longest-lived to shortest-lived: Lymphocytes Erythrocytes Platelets Neutrophils

STEM CELLS IN THE RED MARROW:

STEM CELLS IN THE RED MARROW STEM CELL: A cell that has not matured and differentiated yet. An embryo has lots of stem cells which have not decided to become a nerve cell, muscle cell, liver cell, etc. Stem cells become the type of cell the body needs. The placenta of a newborn infant has many of these stem cells, too, but not as many as an embryo. That’s why people want to research stem cells on embryos; there are more stem cells there.

Stem Cells:

Stem Cells The first step for a stem cell is to DIFFERENTIATE , which is to decide what system of cells it will belong to. A stem cell that matures in the bone marrow will become a blood cell. Adults don’t have too many stem cells that are so immature that they have not yet decided what system of cells to belong to. Most of our stem cells have matured to the next step, which is that they have decided what system to evolve into. An adult has stem cells that will ONLY become blood, nerve tissue, organs, etc.

Blood Cell Formation:

Blood Cell Formation Hematopoiesis – process by which blood cells are formed 100 billion new blood cells formed each day The plasma proteins are made in the liver. The blood cells are made in the red marrow.

Bone Marrow as the Site of Hematopoiesis:

Bone Marrow as the Site of Hematopoiesis Bone marrow – located within all bones Red marrow – actively generates new blood cells Contains immature erythrocytes Remains in epiphyses, girdles, and axial skeleton

Bone Marrow as the Site of Hematopoiesis:

Bone Marrow as the Site of Hematopoiesis Yellow marrow – dormant Contains many fat cells Located in the long bones of adults

RED BONE MARROW:

RED BONE MARROW Most blood cells mature in the red bone marrow. When they are almost completely mature, they are released into the bloodstream. When they are old, they are destroyed in the spleen.

Cell Lines in Blood Cell Formation:

Cell Lines in Blood Cell Formation All blood cells originate in bone marrow All originate from one cell type – blood stem cell Erythroblasts – give rise to red blood cells Lymphoblasts – give rise to lymphocytes Myeloblasts – give rise to all other white blood cells

Stages of Differentiation of Red Blood Cells:

Stages of Differentiation of Red Blood Cells

RBC Development:

RBC Development ERYTHROBLASTS mature until they are ready to enter the circulation. The nucleus gets pinched off as it enters the blood vessel. When a RBC loses its nucleus, it gains room for more hemoglobin. Some bits of its nucleus are still there for about 2 days, so during this time, they are called RETICULOCYTES.

RBC Development:

RBC Development A mature RBC is called an ERYTHROCYTE, which circulates in the blood. If the body makes too few erythrocytes it can lead to one form of ANEMIA.

ERYTHROBLASTS:

ERYTHROBLASTS These mature into RETICULOCYTES , a RBC with bits of nucleus material, which later dissolves to make room for more Hgb. It is now called an E RYTHROCYTE .

LYMPHOBLASTS:

LYMPHOBLASTS Give rise to lymphocytes

MYELOBLASTS:

MYELOBLASTS These are the stem cells that mature into the other leukocytes: Neutrophil , macrophage, eosinophil , basophil , platelets.

Leukemia:

Leukemia Leukemia is cancer of the stem cells. See all these different types of stem cells? That’s about how many types of leukemia there are.

Stages of Differentiation of White Blood Cells:

Stages of Differentiation of White Blood Cells Figure 17.9

Disorders of RBCs:

Disorders of RBCs Polycythemia Anemia Too few RBC’s Iron deficiency Hemorrhagic anemia (person lost blood) Pernicious anemia (lack of vitamin B12 or intrinsic factor) Excess RBC destruction (immune disorder or infection) Hemoglobin abnormalities Thalassemia Sickle cell disease Megaloblastic anemia

Polycythemia Too many RBC’s; can cause clots. Need to donate blood frequently:

Polycythemia Too many RBC’s; can cause clots. Need to donate blood frequently

ANEMIA:

ANEMIA Any condition of RED BLOOD CELLS in which the blood’s capacity for carrying oxygen is diminished.

Anemia:

Anemia Characteristic sign of anemia: see reticulocytes in the blood (immature red blood cells). Remnants of the nucleus are still in the cell.

Reticulocytes:

Reticulocytes

Anemia can be caused by many things. One type of anemia is from too few RBC’s.:

Anemia can be caused by many things. One type of anemia is from too few RBC’s.

Anemia can also be caused from Iron Deficiency:

Anemia can also be caused from Iron Deficiency

IRON DEFICIENCY ANEMIA that was treated with blood transfusion:

IRON DEFICIENCY ANEMIA that was treated with blood transfusion These are the healthy RBCs from blood transfusion

More Causes of Anemia:

More Causes of Anemia Hemorrhagic anemia: loss of blood Pernicious anemia: lack of vitamin B12 or intrinsic factor, which is needed for RBC formation Excess RBC destruction (from an autoimmune disease, infection, etc) Genetic defect in Hemoglobin (deforms the cell)

Slide 93:

TEAR DROP SPHEROCYTE TARGET CELLS Thalassemia A form of anemia where the RBCs have abnormal hemoglobin that deforms the cells

Sickle Cell Disease:

Sickle Cell Disease Present in African Americans more than in other groups, and is always characterized by sickled erythrocytes.

Sickle Cell Anemia:

Sickle Cell Anemia SICKLE CELL

Megaloblastic Anemia:

Megaloblastic Anemia (Large RBCs: Note that the lymphocyte is the same size as the huge RBCs)

Hematocrit:

Hematocrit A quick screening test for anemia is the hematocrit . A drop of blood is drawn up a small glass capillary tube and the tube is centrifuged to pack the red blood cells at the bottom with the plasma on top. Hematocrit measures the percentage of blood volume that consists of erythrocytes. The hematocrit is the ratio of packed red blood cells to total blood volume. Normal is about 45% (46% for men and 38% for women.)

Hematocrit:

Hematocrit

LEUKEMIA:

LEUKEMIA Cancer of the blood is called leukemia. It actually only involves the white blood cells. Something goes wrong in one stem cell, and it starts making huge amounts of clones of itself which don’t work right and not enough normal white blood cells are made. Therefore, the body cannot fight infection. So, the immature white cells are sent into the bloodstream. It’s better to send a young cell with no weapons to the war than to send nothing at all! Think of Leukemia as too few mature white blood cells. Even though the WBC count is high, they are all immature forms.

Disorders of WBCs:

Disorders of WBCs Disorders of leukocytes Leukemia – too few mature WBC’s (may see increase in immature forms); a form of cancer Classified as lymphoblastic (too many immature lymphocytes) or myeloblastic (too many immature neutrophils)

Bone Marrow Transplant:

Bone Marrow Transplant People with severe leukemia may need a bone marrow transplant. First, all of their WBC’s have to be killed off with a medicine because they are mostly malfunctioning anyway. A donor has a small cylinder of bone removed from their hip. This is ground up and given by i.v. to the recipient. The new WBC’s may kill the patient or it may save their life. It is done as a last resort.

Disorders of Platelets:

Disorders of Platelets Thrombocytopenia Abnormally low concentration of platelets Blood does not clot properly

HEMOPHILIA:

HEMOPHILIA A hereditary disease of males, where they are unable to clot properly because they are missing some clotting factors. When they get even a slight bump or bruise they have to have an intravenous infusion of clotting factors or they will bleed to death. This is probably the disease that was in the genes of Henry VIII, which caused all of his male children to become weak and die in infancy.

Blood Clots:

Blood Clots Thrombus A clot in a vessel Embolism a thrombus that broke away and travels in the blood stream. It usually lodges in a smaller blood vessel and blocks circulation distal to that point.

Blood Clots:

Blood Clots Thrombus Embolism

Thrombus:

Thrombus

Thrombus:

Thrombus

BLOOD TYPING: The ABO SYSTEM :

BLOOD TYPING: The ABO SYSTEM Blood typing is the technique for determining which specific protein type is present on RBCs. Only certain types of blood transfusions are safe because the outer membranes of the red blood cells carry certain types of proteins that another person’s body will think is a foreign body and reject it.

BLOOD TYPING:

BLOOD TYPING These proteins are called antigens (something that causes an allergic reaction). There are two types of blood antigens: Type A and Type B. A person with Type A antigens on their blood cells have Type A blood. A person with Type B antigens have Type B blood. A person with both types has type AB blood. A person with neither antigen has type O blood.

BLOOD TYPING:

BLOOD TYPING If a person with type A blood gets a transfusion of type B antigens (from Type B or Type AB, the donated blood will clump in masses (coagulation), and the person will die. The same is true for a type B person getting type A or AB blood. Type O- blood is called the universal donor, because there are no antigens, so that blood can be donated to anyone. Type AB+ blood is considered the universal acceptor, because they can use any other type of blood. This blood type is fairly rare. The rarest blood type is AB negative.

RH FACTOR:

RH FACTOR There is another term that follows the blood type. The term is “positive” or “negative”. This refers to the presence of another type of protein, called the Rh factor. A person with type B blood and has the Rh factor is called B positive. A person with type B blood and no Rh factor is called B negative.

RH FACTOR:

RH FACTOR The reason this is so important is that if an Rh- mother has an Rh+ fetus in her womb (from an Rh+ father), her antibodies will attack the red blood cells of the fetus because her body detects the Rh protein on the baby’s red blood cells and thinks they are foreign objects. This is called Hemolytic Disease of the Newborn (HDN).

HDN:

HDN This can be prevented if the doctor knows the mother is Rh - and the father is Rh +, because that means the baby has a 50% chance of being Rh + like the father. Therefore, anytime a mother is Rh -, even if the mother says the father is Rh -, you can’t be sure who the father is, so they will proceed as though the baby may be Rh +. They will give her an injection of a medicine ( Rhogam ) that will prevent her immune system from attacking the baby.

Rhogam:

Rhogam Rhogam is given at 18 weeks into the pregnancy and again within 72 hours after giving birth. It is usually given within 2 hours after giving birth since you can’t trust the patient to return after they leave the hospital. The first baby is not at risk; during the first birth (or miscarriage), the placenta tears away and that’s when the baby’s blood cells get into the mother’s bloodstream. She then forms antibodies against the Rh factor, which are ready to attack the second fetus. The baby does not make the Rh factor until about 18 weeks into the pregnancy.

IMMUNE SYSTEM:

IMMUNE SYSTEM INFLAMMATORY REACTION: When you get stuck by a thorn or have an infected cut, the body goes through a series of events called an inflammatory reaction. Four outward signs: Redness (erythema or rubor ) Heat ( calor ) Swelling (edema) Pain (dolor)

INFLAMMATORY REACTION:

INFLAMMATORY REACTION Redness is caused from the blood vessels dilating to allow more blood flow to the area. Within the blood are platelets to clot the blood, proteins to repair the damage, and macrophages, which are white blood cells that eat up the foreign body, bacteria, or the dead cells. Heat is caused because of the extra amount of warm blood flow to the area. Swelling is caused from the plasma that leaks out of the swollen blood vessels. Pain is caused from the pressure of the extra fluid pressing on nerves in the area.

ADAPTIVE IMMUNITY:

ADAPTIVE IMMUNITY Two types of Adaptive Immunity ACTIVE immunity Naturally Acquired Artificially Acquired PASSIVE immunity Naturally Acquired Artificially Acquired You can also think of it this way

Active Immunity:

Active Immunity Naturally Acquired The body is naturally exposed to an infectious agent and launches an immune reaction Artificially Acquired The person is injected with a weakened (attenuated) or killed organism, as found in a vaccination

Naturally Acquired Active Immunity:

Naturally Acquired Active Immunity This is when the body is exposed to an infectious agent and the body has to work to produce antibodies which specifically attack that infectious agent. The white blood cells secrete these antibodies which will continue to circulate sometimes for years, ready to attack that type of bacteria and cause them to pop like a balloon before the body can become sick.

Naturally Acquired Active Immunity:

Naturally Acquired Active Immunity You catch a cold and eventually get better. You can never get the same cold virus twice because you will have become immune to it. Your next cold is from a different virus. There are hundreds of thousands of cold viruses; that’s why there is no cure for the common cold. Another example is when an unvaccinated child is exposed to the measles at school and gets the disease, but never gets the disease again.

Slide 125:

However, there are some diseases that you don’t want to get, even once, such as polio, diphtheria, tetanus, and influenza, because the first exposure could kill or disable you. For these diseases, we have vaccines which are made of those organisms which have been altered (attenuated) so that the body recognizes them as foreign, but they can’t cause disease. That way, if the person is exposed to the real organism later, the antibodies are already there to kill it off without the body getting sick.

Artificially Acquired Active Immunity:

Artificially Acquired Active Immunity An example is when a child is vaccinated against measles as a baby, so when he gets to school and is exposed to the disease, he doesn’t get sick.

Passive Immunity:

Passive Immunity Naturally Acquired Example is the passing of antibodies from mother to infant in breast milk Artificially Acquired Example is when a person receives an infusion of antibodies from someone else.

Active vs. Passive Immunity:

Active vs. Passive Immunity Active immunity is long-lived, and may last for years or even a life time. Passive immunity is short lived, and may last only for a few months. NOTE: A vaccination is not the same as receiving an anti-toxin or anti-venom injection. More on that in Micro class.

ALLERGIES:

ALLERGIES From a hypersensitivity to substances such as pollen or animal hair that would not ordinarily cause a reaction. There are two types of allergic responses: Immediate Delayed

Immediate allergic response:

Immediate allergic response Occurs within seconds of contact with the thing causing the allergy. This is the case with anaphylactic allergies, where someone who is allergic to seafood or peanuts can actually die within minutes because the allergic reaction is so severe the throat swells shut and they can’t breathe. They need an injection immediately of something that will stop the reaction.

Delayed allergic response:

Delayed allergic response Delayed allergic response is when the body’s first exposure to the substance will not cause a reaction, but all exposures afterward will trigger the response. An example is poison ivy. You won’t itch the first time you touch it.

AUTOIMMUNE DISEASE:

AUTOIMMUNE DISEASE A hereditary problem where the body thinks its own tissues are foreign bodies, and it constantly tries to kill off its own tissues.

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