logging in or signing up Complement system varuncn Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 885 Category: Science & Tech.. License: All Rights Reserved Like it (0) Dislike it (0) Added: December 05, 2012 This Presentation is Public Favorites: 0 Presentation Description A brief description of complement pathways Comments Posting comment... Premium member Presentation Transcript Complement system: Varun C N www.microboids.net Complement systemPowerPoint Presentation: Varun C N- Complement system 2PowerPoint Presentation: Complement system pathways: Classical pathway Alternative Pathway Lectin pathway Varun C N- Complement system 3PowerPoint Presentation: Daniel Ricklin & John D Lambris Nature Biotechnology 25, 1265 - 1275 (2007 ) Varun C N- Complement system 4PowerPoint Presentation: Varun C N- Complement system 5 Activation of complement system C3 convertase C5 convertase MACPowerPoint Presentation: Complement system 6 Structure of C1 molecule Source: Kuby; 5 th ed Classical PathwayPowerPoint Presentation: Varun C N- Complement system 7PowerPoint Presentation: Varun C N- Complement system 8 Alternative pathwayPowerPoint Presentation: Varun C N- Complement system 9 http://www.crystal.chem.uu.nl/~gros/figs/cvf-b-large.jpgPowerPoint Presentation: Varun C N- Complement system 10 http://www.crystal.chem.uu.nl/~gros/figs/c3bbd-large.jpgPowerPoint Presentation: Varun C N- Complement system 11 Activation of the terminal complement pathway results in formation of membrane-attack-complexes (MAC) that form large (100 Å wide) pores in the target membrane. http://www.crystal.chem.uu.nl/~gros/complement.htmlPowerPoint Presentation: Varun C N- Complement system 12PowerPoint Presentation: Varun C N- Complement system 13 Classic Alternative First reactant C1q C3b Reaction trigger Antigen Antibody complex Microbial products C3 convertase C14b2a C3bBb C5 convertase C14b2a3b C3bBb3bPowerPoint Presentation: Varun C N- Complement system 14 Component Biological Activity C2b Prokinin ; cleaved by plasmin to yield kinin , which results in edema C3a Anaphylotoxin ; can activate basophils and mast cells to degranulate resulting in increased vascular permeability and contraction of smooth muscle cells, which may lead to anaphylaxis C3b Opsonin ; promotes phagocytosis by binding to complement receptors Activation of phagocytic cells C4a Anaphylotoxin (weaker than C3a) C4b Opsonin ; promotes phagocytosis by binding to complement receptorsPowerPoint Presentation: Varun C N- Complement system 15 Kuby; 5 th edPowerPoint Presentation: Complement system 16 Thurman etal. Laboratory Investigation (2011) 91, 4–11 Nature Publishing groupPowerPoint Presentation: Varun C N- Complement system 17 Kuby; 5 th ed Functions of complement systemPowerPoint Presentation: 18 Complement system Disease Mechanism C1INH Hereditary angioedema Overproduction of C2b ( prokinin ) C1, C2, C4 Predisposition to SLE Opsonization of immune complexes help keep them soluble, deficiency results in increased precipitation in tissues and inflammation Classical Pathway Gene Mayer; Immunology Deficiency of complement components and associated diseasePowerPoint Presentation: Complement system 19 Factors B or D Susceptibility to pyogenic (pus-forming) bacterial infections Lack of sufficient opsonization of bacteria C3 Susceptibility to bacterial infections Lack of opsonization and inability to utilize the membrane attack pathway C5 , C6, C7 C8, and C9 Susceptibility to Gram-negative infections Inability to attack the outer membrane of Gram-negative bacteria Properdin (X-linked) Susceptibility meningococcal meningitis Lack of opsonization of bacteria Factors H or I C3 deficiency and susceptibility to bacterial infections Uncontrolled activation of C3 via alternative pathway resulting in depletion of C3 Alternative Pathway Gene Mayer; ImmunologyPowerPoint Presentation: Varun C N- Complement system 20 You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.