Blood cells

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Blood Cells Varun C N

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Each type of leukocyte is present in the blood in different proportions: Neutrophil 50 - 70 % Eosinophil 2 - 4 % Basophil 0.5 - 1 % Lymphocyte 20 - 40 % Monocyte 3 - 8 % Neutrophils are very active in phagocyting bacteria and are present in large amount in the pus of wounds. Unfortunately, these cells are not able to renew the lysosomes used in digesting microbes and dead after having phagocyted a few of them. Eosinophils attack parasites and phagocyte antigen-antibody complexes. Basophil secrete anti-coagulant and vasodilatory substances as histamines and serotonin. Even if they have a phagocytory capability, their main function is secreting substances which mediate the hypersensitivity reaction. 4 Varun C N

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Eosinophils Large specific granules Major basic protein (MBP) Eosinophil cationic protein (ECP) Eosinophil derived neurotoxin (EDN) Eosinophil peroxidase (EPO) Small granule Aryl sulphatase, acid phosphatase 92 kDa metalloproteinase Gelatinase. 7 Varun C N

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Basophil Histamine Proteoglycans-Heparin, chondroitin Proteolytic enzymes- Elastase, lysophospholipase. 8 Varun C N

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Lymphocytes T cells B cells Helper Cytotoxic Memory Regulatory Natural killer (CD4 + T cells) (CD8 + cells) Either CD4 + or CD8 + CD45RO 9 Varun C N

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Regulatory T-cells CD4 + regulatory T cells Naturally occurring T reg cells (CD4 + CD25 + FoxP3 + T reg cells ) FoxP3 + The adaptive T reg cells (Tr1 cells or Th3 cells ) Myeloid (CD11c+) Plasmacytoid (CD123+) Uncharacterized 10 Varun C N

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Plasma cells B cell types Memory B cells B-1 cells Follicular B Cells B-2 cells Marginal-zone B cells 11 Varun C N

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A large, circulating, phagocytic white blood cell, having a single well-defined nucleus and very fine granulation in the cytoplasm. 3 types of monocytes in human blood Classical CD14++ CD16- monocyte The non-classical monocyte CD14+CD16++ The intermediate monocyte CD14++CD16+ 12 Varun C N

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Platelets are composed of three principal components Membrane structures Microtubules Granules 14 Varun C N

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Varun C N 15 Thank you for your kind attention You can also follow me at my blog. Varuncnmicro.blogspot.com