TESTING ON COSMETIC INGREDIENTS

TESTING ON COSMETIC INGREDIENTS AND THEIR SAFETY EVALUATION : 

TESTING ON COSMETIC INGREDIENTS AND THEIR SAFETY EVALUATION SUBMITTED BY B.Vamsikrishna Reddy M.Pharm first year Pharmaceutics, MCOPS, Manipal. Phone:+91-9008418512 vamsikrishnareddy57@gmail.com

CONTENTS : 

CONTENTS Definition Types of Cosmetic ingredients Control over ingredients Types of Hazards Safety evaluation Challenges in safety evaluation Conclusion References

DEFINITION : 

DEFINITION Any chemical substance or preparation of synthetic or natural origin, used in the formulation of cosmetic products.

Types Of Cosmetic Ingredients : 

Types Of Cosmetic Ingredients Active ingredient Preservatives Antioxidants Coloring agents Miscellaneous

CONTROL OVER INGREDIENTS : 

CONTROL OVER INGREDIENTS Restrictions and prohibitions on ingredients by EU Cosmetic Directive and they are Annex2-Negative list Annex3- Restricted list Annex4- Positive list of Colorants Annex6-Positive list of Preservatives Annex7-Positive list of UV filters

TYPES Of HAZARDS : 

TYPES Of HAZARDS Topical effects Skin irritation Eye irritation Mucous membrane irritation Skin sensitization Systemic effects

SAFETY EVALUATION : 

SAFETY EVALUATION Irritation and corrosivity Skin sensitization Dermal/percutaneous absorption Repeated dose toxicity Mutagenicity/genotoxicity, Carcinogenicity Reproductive toxicity Toxicokinetics Photo-induced toxicity

Ethical Constraints In Human Testing : 

Ethical Constraints In Human Testing By eliminating animal testing, the need for human testing is increased Confirmatory safety tests are sometimes necessary and can be carried out in man. SCCNFP came to the conclusion that confirmatory tests on humans can only be considered when the toxicological profiles of all ingredients and of the finished cosmetic product, based on animal and/or alternative methods, are available and have all been found favorable

Challenges in safety evaluation : 

Challenges in safety evaluation Moving from in vivo to in vitro testing. Urgent need for appropriate exposure data. New role of raw material suppliers. The need for appropriate training. Ethical constraints in human testing. Special problems for small and medium enterprises (SMEs).

CONCLUSION : 

CONCLUSION Safety evaluation of cosmetic ingredients are necessary before formulation of cosmetic products and it helps to save money and time

REFERENCES : 

REFERENCES http://www.Ispe.it/en/defaultz.html http://www.cfsan.fda.gov/~dms/cos_toc.html Fischer AA. Cutaneous reactions to cosmetics, 2 nd edition Philadelphia: Lea and Febiger; 1973. p. 217-41.

THANK YOU : 

THANK YOU