logging in or signing up drug discovery and development up62m2134sam Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 1923 Category: Entertainment License: All Rights Reserved Like it (1) Dislike it (0) Added: March 13, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... By: zhuthegreat (38 month(s) ago) very good Saving..... Post Reply Close Saving..... Edit Comment Close By: zhuthegreat (38 month(s) ago) good Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript drug discovery and development : drug discovery and development SAMIR KUMAR GUPTA ENROLL-NO- 28830 BATCH -2nd INTRODUCTION : INTRODUCTION FOR MORE THAN 40 YEAR, DRUG DISCOVERY AND DEVELOPMENT HAS BEEN ONE CORE RESEARCH ACTIVITIES WE WORK WITH PHARMACEUTICAL COMPANIES & GOVERNMENT AGENCIES TO BRING NEW MEDICINES TO MARKET, AND TO ENSURE THE SAFETY AND EFFICACY OF THOSE IN THE MARKETPLACE. How are new drugs discovered? : How are new drugs discovered? NEW DRUGS BEING IN THE LOBORATORY WITH SCIENTISTS,INCLUDING CHEMISTS AND PHARMACOLOGISTS. THEY IDENTIFY CELLULAR AND GENETIC FACTORS THAT PLAY A ROLE IN SPECIFIC DISEASES. THEY SEARCH FOR CHEMICAL AND BIOLOGICAL SUBSTANCES THAT TARGET THESE BIOLOGICAL MARKERS AND ARE LIKELY TO HAVE DRUG-LIKE EFFECTS. PROCESS OF NEW DRUG DISCOVERY & DEVELOPMENT : TARGET IDENTIFICATION. TARGET VALIDATION. EXAMINE DEVELOPMENT & SCREENING. HIT TO LEAD SELECTION. LEAD OPTIMIZATION. CONDIDATE SELECTION. MANUFACTURING PROCESS OF NEW DRUG DISCOVERY & DEVELOPMENT TARGET IDENTIFICATION- : TARGET IDENTIFICATION- Drugs usually act on either cellular or genetic chemicals in the body, known as targets, which are believed to be associated with disease. Scientists use a variety of techniques to identify and isolate individual targets to learn more about their functions and how they influence disease. Compounds are then identified that have various interactions with the drug targets that might be helpful in treatment of a specific disease. TARGET VALIDATION- : TARGET VALIDATION- To select targets most likely to be useful in the development of new treatments for disease, researchers analyze and compare each drug target to others based on their association with a specific disease. Tests are conducted to confirm that interactions with the drug target are associated with a desired change in the behavior of diseased cells. EXAMINE DEVELOPMENT & SCREENING : EXAMINE DEVELOPMENT & SCREENING Easily determine optimum solution conditions. Predictive tool that corresponds well to industry standards for assessing long-term stability. Predict the tendency to aggregate. Easily determine the stability contribution of individual percipients. HIT TO LEAD SELECTION : HIT TO LEAD SELECTION A lead compound or substance is one that is believed to have potential to treat disease. Laboratory scientists can compare known substances with new compounds to determine their likelihood of success. Leads are sometimes developed as collections, or libraries, of individual molecules that possess properties needed in a new drug. Testing is then done on each of these molecules to confirm its effect on the drug target. LEAD OPTIMIZATION : LEAD OPTIMIZATION Lead optimization compares the properties of various lead compounds and provides information to help biopharmaceutical companies select the compound or compounds with the greatest potential to be developed into safe and effective medicines. MANUFACTURING : MANUFACTURING CHOOSE THE NEW DRUG AND THEN MANUFACTURING THE PRODUCT. MANUFACTURING THE USE FULL DRUGS. THANKS : THANKS You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.