Presentation on Lactobacillus heliveticu

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??????????????????? : 

??????????????????? ???? zhaozheng@163.com

????????????? : 

????????????? ???????2005????????????????????,?????????????,2006???10????? ?????????; ??????; ?????; ????????????

CFDA???????? : 

CFDA???????? ??????????????????????,????????????????????????????????,???????????????? http://www.gdfs.gov.cn/zcfg/ShowArticle.asp?ArticleID=1424

???????????? : 

???????????? ?????? Bifidobacterium bifidum ?????? Bifidobacterium infantis ????? Bifidobacterium longum ????? Bifidobacterium breve ?????? Bifidobacterium adolescentis ?????????? Lactobacillus delbrueckii subsp. Bulgaricus ????? Lactobacillus acidophilus ????????? Lactobacillus casei subsp. Casei ????? Streptococcus thermophilus ?????? Lactobacillus reuteri http://www.gdfs.gov.cn/zcfg/ShowArticle.asp?ArticleID=1424

??????? : 

??????? ?????,(Lactobacillus helveticus)0.6-1.0×2.0-6.0 ??,?????,??????? ???????42?,??????,????2~3 ?????,?????,??????,??????? ???????????,??Swiss, Parmesan, Romano, Provolone ? Mozzarella??????

??????? : 

??????? ????????????Val-Pro-Pro?IIe-Pro-Pro???? ????????????????(ACEIPs)?C-??Pro????????? ?????????? ???????????????????????????? ?????????????????

Slide 8: 

??VALIO????????“EVOLUS”??????????2005????????????20??????????? VALIO?????“EVOLUS”??????? ??????????? ??CALPIS????????????????????????????????????????????????,?????10??????????

Slide 9: 

http://www.valio.fi/portal/page/portal/valiocom/Valio_worldwide/Subsidiaries/valio_ltd._shanghai_representative_office04082006150253

Slide 10: 

http://www.valio.fi/portal/page/portal/valiocom/R_D/Nutritional_research ???? ????? ?????? ???? ?????? ????????? ?????

Valio????????? : 

Valio?????????

EVOLUS??????? : 

EVOLUS??????? ??????????ACE????,????????????????? ??????Evolus???SHR ?????????,???????????

??????????? : 

??????????? ??????????????????(CPPs)?????????????????,????????????? Narva??????????????????????????????????, ?????????? ???????????????????,???????????? ???????????CPPs????????Kawahara?????????????????CPPs ? ?EVOLUS????,????????????????????CCPs????????

Calpis?????? : 

Calpis?????? ????(Calpis,????)??????????????????????(calcium )?+???(sanbis ?????)???? 1902?,Calpis????????????????????????????1915??????????????????? ????????????????????????????? 1991?,?CALPIS WATER????CALPIS??????? ?CALPICO Concentrate???????????? Calpis????????????????????? http://info.tjkx.com/news/00001098EF/2007-11-13/95796C3E9A.html

Slide 15: 

Feed Additives Improve feed efficiency Increase body weight Lactic dairy beverage and water Dietary supplement Maintain healthy blood pressure Ameal Peptide clinically proven, bioactive ingredient maintain healthy blood pressure. ??CALPIS??

Slide 16: 

?8??,???????95ml???????? ????????????(?15mm Hg),???????????? ???????????????????????500ml??????? ?????????????????? ???????

Slide 17: 

??3?ICR??,????+???????+? ?,????????? ?????????91.8±20.0?? ???84.4±17.4?????84.9±18.9?? ?????????8%,?????? Calpis???????

????????? : 

????????? ???????????? ????????????????????? ?

Slide 19: 

??????????????,???????????? ?????,???????????????? ?????????????????????? ??????? ????????

???????? : 

???????? ??????????:?????????????????;????????;??????????;?????? Vesely??(1990)???????????????????,???????????180 ???????? kitazaw?(2002) ?????????????9 ????? (S-180) ????,????????????????????????????T????,?????????????

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????????

Slide 22: 

?????????????NK??(natural killer cell,??????)????? ?YAC-1??????, ????,?????????????????? Sinmon??,????????????????????IgA??? ? Goulet ??,??????????????,??????????????????????????????????? ??????????????????????? ?????

????? : 

????? Matar(2002)????????????????????????? ??HPLC?,???????????? ????,??IgA??? HPLC???????????IgA?

???? : 

???? ??????????????????,??????????????(MDP )? Krueger??????????????,????????,??????????,????????????IL-1-ß?TNF-a???? ?????????????????????????????,????????????????????????(MDP),???????????????????

??? : 

??? ????? MIMLh5 ?????????????????,???? ????? ??????,???????????? Wataru Aoi,(2007)?????????????????????? 24h?,???????????????????????????????????????????????????????? ?????mRNA ??????????????,????????????????????, ?????????????????

????????????????????????????? : 

????????????????????????????? 2004??????????????????????????,??????????????? ??????????????? 2006?“?????????????????????”?????????????????? 6???????6????????????????,???????

??????????????? : 

??????????????? ?????????????????????? ????????????? ?????????????????? ??????????????????? ?????????????ACE????? ???????????CPPs???

Slide 28: 

?????????????,????????????????,????????????,???????pro???2~9?? ??????????????????????

?????????????????????????????????? : 

??????????????????????????????????

?????????????????????????? : 

?????????????????????????? ??8??SD??????????????????????????????? ???????????,??????(??8?),?????????????,???????????????,????10?????X???????????????????????????????????,?????????? ?????????????????,??????????????????,???????????????????????????????????????,????????????????????????????????????????????????,?????????? ???????????????,??????????????????????????,????????????

??????????????? : 

??????????????? ????????????Camembert??? ?????????CPPs????6.12 g/L,N/P? 11.17? ??????CPPs????3.12 g/L; ??????????CPPs????7.92 g/100g???N/P?11.12? ?? ??????CPPsN/P?8.49,???????CPPsN/P?8.39?

?????????????ACE????? : 

?????????????ACE????? ??????ACE???????????,???,3 d?,??????????

?????TUST005???ACE???? : 

?????TUST005???ACE????

?????????SHR??? : 

?????????SHR???

SHR??????? : 

SHR??????? ????????????????, ?????(40±1) ? ??????, ??10 min, ??????????, ?????????? ?????1?,???????, ?????,?????????,????1?,??ZH-HX-Z?????????????0?1?2?3?4?5?6?7 h?SHR??????(systolic blood pressure; SBP)???(heart rate; HR),???3?,??medlab??????,????? ????3?,???????

??SHR????????? : 

??SHR????????? SHR??6???????????,??24??????????????,?????????? ????6???SHR??ACEI???,?????????????????,?????????,??????????????????ACEI????????????????????????? ??ACEI??????????????????????????,???????

?SHR??????? : 

?SHR??????? ???????????????,?????? ???,???????????????????? 14.2±2.1,15.9±1.7bpm,???????????( P >0.05) ?

Slide 39: 

??????,TC?TG??????(p<0.05)? ACEI???????????????????????? ?????SHR????????????, ????????????????????? ????????????????? ????????

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?????????????? ????????????? ???????????? ?????????????? ?????????????? ????????????????

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