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angiotensin receptors and their transducer mechanism

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ANGIOTENSIN RECEPTORS Presented by- Toshit Sharma M.Pharm (Pharmacology) j

Angiotensinogen :

Angiotensinogen Human plasma contains a glycoprotein called angiotensinogen . which serves as the only known substrate for renin. Angiotensinogen is synthesized in many organs, including the liver, brain and kidney. Angiotensinogen also has been found in large quantities in cerebrospinal.

Angiotensin Pathway:

Angiotensin Pathway

Receptors :

Receptors AT 1 and AT 2 receptor . AT 1 receptors – AT 1 receptor is a member of the seven transmembrane G protein couple receptor family. Binding of Ang -II to the AT 1 receptor. Stimulation of phosholipase C Activation of protein kinase C release of interacellular Ca ++

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Location :- vascular smooth muscle,Adrenal cortex and medulla,uterus,Brain,liver,and Heart . AT 2 Receptor Member of seven transmembrane G protein couple receptor family. Location :- Adrenalgland,Brain,uterus,kidney,Heart , and reproductive tissue.

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Recently studies show that,the AT 4 Receptor is a novel binding site that have high affinity for Ang -IV. Distribution :- Brain,Kidney . Function :- It mediating cerebal and Renal blood flow. Memory retention. Neuronal development .

TRANSDUCER MECHANISMS AT1Receptor:

TRANSDUCER MECHANISMS AT 1 Receptor IP 3 and DAG Pathway

TRANSDUCER MECHANISMS OF AT2:

TRANSDUCER MECHANISMS OF AT 2

Biological action of Angiotensin II:

Biological action of Angiotensin II Blood pressure :- Influences B.P Adrenalcortex :- stimulate the Aldosterone synthesis and release. At higher conc. Ang II stimulate Glucocorticoid Synthesis . kidney :- Renal vasoconstriction, increase sodium reabsorption .

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Central nervous system :- stimulate the drinking,and increase the secretion of vassopressine . ANS :- Stimulation of sympathetic,facilitation of adrenergic transmission,release of NA. CVS :- positive inotropic action .

Function of AT2 Receptor:

Function of AT 2 Receptor It play a important role in foetal development. Recent studies show that,the AT 2 receptor is involved in the production of cGMP , NO, Prostaglandin, Vasodilation and B.P regulation.

Role of renin:

Role of renin

AT1 Receptor Antagonists:

AT 1 Receptor Antagonists CGP 38560 A Compund 10. Compound rac – 30. Saralasin . Losartan . Valsartan . Eprosartan . Irbesartan . Candesartan . Olmesartan . Telmesartan .

AT2 Receptor antagonists:

AT 2 Receptor antagonists PD 123177. PD 123319. CGP42112.

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