Marrow Failure powerpoint.

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Marrow Failure Syndromes: 

Marrow Failure Syndromes 1 www.HemOnc101.com

Marrow Failure Syndromes: 

Marrow Failure Syndromes -Bone marrow failure indicates the inability of hematopoiesis to meet the demands of production. -May be either congenital or acquired. www.HemOnc101.com 2

Diamond-Blackfan Anemia (DBA): 

Diamond-Blackfan Anemia (DBA) A 2 month old infant presenting with craniofacial malformations, thumb as well as upper limb abnormalities, cardiac defects, urogenital malformations, and a cleft palate. WBC and platelet count normal but hemoglobin 5g/dL, macrocytic with low reticulocyte count. Negative Coombs’ test, normal haptolgobin, normal B12, folate, TSH. Bone marrow reveals normal myeloid cells and megakaryocytes but marked reduction in immature proerythroblasts. -DBA is a congenital erythroid aplasia which usually presents in infancy. www.HemOnc101.com 3