Aging

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V. Onur Yılmaz - 130104002

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Outline Tumor immunity Tumor immunity dynamics Tregs and antitumor Teffs coexists at tumor emergence Tregs outrun Teffs at tumor implantation Immunity at induced tumors MHC class II dependency Elimination of dividing T cells Role of memory status Discussion

Tumor Immunity : 

Tumor Immunity Considerable evidence about establishing Tumor immunity by Tregs Function Maintainance of self tolerance, control of auto-immune diseases Treg markers in this paper: CD4+ and Foxp3+ Tregs are normally at steady state, but some memory Tregs are active

Tumor Immunity : 

Tumor Immunity Early responses of Tregs and Teffs to tumor is poorly characterized. Cancer cells express self antigens Self antigens are recognized by activated/memory CD44+ Tregs(amTregs)

Tregs and Teffs coexists at tumor emergence : 

Tregs and Teffs coexists at tumor emergence Figure 1: 4T1 mammary tumor cells are implanted to mice. Total number of Tregs after tumor innoculation (A-B). Treg depleted mice with anti-CD25 and survival Cured mice rejected new tumor implantation after survival. (data not shown) Anti-tumor Teffs are overpowered by Tregs, shown by anti-CD25 treatment

Tregs outrun Teffs at tumor implantation : 

Tregs outrun Teffs at tumor implantation

Tregs outrun Teffs at tumor implantation : 

Tregs outrun Teffs at tumor implantation

Tregs outrun Teffs at the time of tumor emergence in mice with doxycycline inducible expression of polyoma middle T oncogene : 

Tregs outrun Teffs at the time of tumor emergence in mice with doxycycline inducible expression of polyoma middle T oncogene

Early Treg response by amTregs and MHC-II dependent : 

Early Treg response by amTregs and MHC-II dependent

Early Treg response by amTregs and MHC-II dependent : 

Early Treg response by amTregs and MHC-II dependent

Elimination of Tregs with antimitotic drugs : 

Elimination of Tregs with antimitotic drugs

Role of Memory status : 

Role of Memory status

Discussion : 

Discussion