logging in or signing up FILARIASIS sunethweerarathna Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 335 Category: Education License: All Rights Reserved Like it (0) Dislike it (0) Added: June 18, 2012 This Presentation is Public Favorites: 0 Presentation Description common parasitic infestation in Sri lanka. Comments Posting comment... Premium member Presentation Transcript FILARIASIS: FILARIASISFilariasis- Learning Objectives: Filariasis- Learning Objectives Be able to recognize spectrum of diseases caused by filarial worms in Sri Lanka Different diagnostic methods and their utility Understand the basis of treatment protocols Aware of preventive measures used in Sri LankaFilariasis- main types : Filariasis- main types Lymphatic – Wuchereria Bancrofti Brugia Malayi S.cutaneous– Onchocerca volvulus & ocular Loa LoaLymphatic Filariasis: Lymphatic Filariasis Worldwide distribution in Asian African and Pacific Islands Caused by W. Bancrofti in SL Vector – Anopheles, Culex and Aedes mosquitoes Breeding and biting habits influence the epidemiology of these infections Human disease is caused by prolonged and repeated infectionsLymphatic Filariasis- Clinical Features: Lymphatic Filariasis- Clinical Features Depend on – area of transmission age of the first exposure degree of exposure Sex of the Individual Immune response of the host [hyper / hypo immune]Clinical Features : Clinical Features Acute – Fever malaise, headache,3-7 days Lymphangitis and /or Lymphadenitis Epidedemo orchitis, Hydrocele Due to immune mediated – nocturnal cough, UrticariaClinical Features – Chronic : Clinical Features – Chronic Occur due to prolonged exposure or repeated acute attacks Hydrocele Lymphoedema Elephantiasis Chyluria – due to obstruction & rupture of abdominal lymphatics to urinary bladderClinical Features : Clinical Features Tropical Pulmonary Eosinophilia due to immune reaction for microfilaria Characterized by high eosinophil count Paroxysmal nocturnal cough resembling bronchial asthma Typical Chest radiographic findings [mottling] Lung function tests show obstructive + restrictive patternDiagnosis : Diagnosis Established case- Clinical Diagnosis Parasitological Diagnosis by finding microfilaria, tissue diagnosis of lymph nodes , New diagnostic methods with high sensitivity using antigen and antibody assays are being developedDiagnosis by Microfilaria : Diagnosis by Microfilaria In thick blood film, hydrocele fluid, urine Problems due to periodicity and need for personnel with experience May not be present in early and late stage of the disease Has a variable correlation with the clinical disease.Immunological methods: Immunological methods Antibody tests Antigen TestsImmunological methods Antibody tests- : Immunological methods Antibody tests- FAT – Filarial Antibody Test Not useful as a diagnostic tests at all !!! [due to high rate of false positive, do not indicate clinical disease, do not differentiate past infection from current disease ]Immunological methods – Antigen tests: Immunological methods – Antigen tests ICT – Immune Chromatography Test Expensive , not routinely available May indicate past infectionImmunological Tests - New: Immunological Tests - New Ig-G subclasses against specific filarial antigens developed Has been shown to be positive in saliva, Urine in addition to blood Can be used as a tests to evaluate therapeutic efficacy Still initial stages of developmentManagement: Management DEC – Drug of choice Kills microfilaria and adult worms dose 6 mg/kg given annually as mass treatment campaigns [along with Albendazole 400mg to supplement its anti filarial action.Management: Management Lympangitis – Oral Antibiotics to cover against common skin pathogens- Erythromycin Elevation Diuretics to reduce swelling – cosmetic/early recovery/ functional gainManagement : Management Elephantiasis- Prophylaxis against bacterial skin sepsis [oral penicillin/ monthly benzathine penicillin ] Good foot hygiene, nail care, raising the foot at night appropriate footwear Periodic DEC to prevent re infectionManagement: Management Hydrocele – Surgery Elephantiasis – Surgical care in specialized centers – Shunt surgery , removal of excess tissue You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.