sumit ppt

Temperature based drug delivery : 

Temperature based drug delivery SUMIT KUMAR MITTAL M.PHARMA(1 ST SEM) QUALITY ASSURANCE ISF College of Pharmacy, Moga

Drug Delivery: 

Drug Delivery Drug delivery is the delivery of the drugs to receptors or organs or any specific part of the body to which one wishes to deliver exclusively.

Classification of Targeted Drug Delivery: 

Classification of Targeted D rug D elivery 1.Passive targeting 2.Inverse targeting 3.Active targeting: a. Ligand b.Physical : pH based targeting Temperature based targeting 4.Double targeting 5.Combination targeting

Temperature based drug delivery: 

Temperature based drug delivery Release rate of drug from the formulation is controlled by variation in the temperature. Examples: Suppositories Temperature sensitive Liposomes

Suppositories: 

Suppositories Medicated solid dosage form intended for use in the rectum, vagina and lesser extent in urethra. Prepared from vehicle which melt or soften at body temperature like theobroma oil (about 36 0 c) and release their drug content locally which get absorbed through rectum mucosa. Suppository bases must melt at rectal temperature .

Uses: 

Uses It is used for treatment of constipation and hemorrhoids. Also used as an analgesic, antibacterial and antispasmodic. Used for systemic action in condition where oral medicament lead to nausea and vomiting .

PowerPoint Presentation: 

Examples: Dulcolex Panadol

PowerPoint Presentation: 

IT IS NEW APPROACH FOR CONTROLLED DRUG DELIVERY SYSTEM.

Temperature sensitive polymers: 

Temperature sensitive polymers Have a critical solution temperature (typically in water) at which the phase of polymer and solution is changed. LCST- Polymer solution that appears as monophasic below a specific temperature & biphasic above it. Lower critical solution temperature of most polymer is between 25-32 c close to body temperature.

Hydrogels : 

Hydrogels These system have property of control delivery system based on sol gel phase conversion. At lower temperature hydrogen bonding between hydrophilic segment of polymer chain & water molecule dominate leading to enhance dissolution in water. As the temperature increase hydrophobic interaction among hydrophobic segment increases while hydrogen bonding becomes weaker, the net result in shrinkage of hydrogel due to interpolymer chain association though hydrophobic interaction .

PowerPoint Presentation: 

PNIPAAm PDEAAm Example:

Uses: 

Uses Prevent undesirable side effects. Increased drug accumulation in pathological area. Sustained effects. Increased bioavailability.

Disadvantages : 

Disadvantages Non biodegradable. Carcinogenicity. Non biocompatibility.

Temperature sensitive liposomes: 

Temperature sensitive liposomes Proliferating cells with increased metabolism have higher temperature as in case of tumour cells than the normal body cells. Low temperature sensitive liposomes are prepared using 1,2 dipalmitoyl-sn-glycero-3-phosphoglyceroglycerol (DPPGOG) in combination with 1,2-dipalmitoyl-sn-glysro-3-phosphocholine which release their drug content at tumour site because of mild hyperthermia. Change in physical state of liposomes lead to enhanced permeability of encapsulated membrane which release drug content.

Advantages: 

Advantages Drug delivery to tumour cells is 30 times more than free drug & 3-5 times greater than traditional liposomes . As the mild hyperthermia,a temperature which increases blood flow and tumour permeability which is easily achievable in deep & superfacial tumour lead to increased drug delivery. Reduction of unwanted side effects of chemotherapy.

THERMODOX : 

THERMODOX It contains heat activated liposomal encapsulation of doxorubicin. The drug has cleared the preclinical studies and undergoining phase 3 clinical trials. It is given I.V. Used in breast cancer & liver cancer. Developed by celsion pharma

PowerPoint Presentation: 

Liposomes loaded with doxorubicin

Ocular drug delivery: 

Ocular drug delivery Drug in solution form is instilled into the eyes which form gel at body temperature. Polymer used are:- Poloxamer Cellulose derivative Xyloglucan Examples :- Bioavailability of pilocarpine is increased by poloxamer Timolol eye drop.

Advantages : 

Advantages Reduced no. of applications Better patient compliance Increased bioavailability Minimization of interference with blinking Sustained effect.

Nasal drug delivery : 

Nasal drug delivery It is used for delivery of proteins & peptides. Example – insulin (tested on animals) Mixture of thermo-sensitive polymer chitosan & polyethylene are used.

References: 

References www.wikipedia.com 1. Rathore KS, Nema RK, Ishibashi Tejraj , Yokoi N, Born JA, Tiffany MJ, Komuro A. Review on Ocular inserts International Journal of Pharm Tech Research (2); 2009: 164-169. 2.Rathore KS, Nema RK. Formulation and evaluation of ophthalmic films for timolol maleate . Planta indica4; 2008:49-50. 3.Keister JC, Cooper ER, Missel PJ, Lang JC, Hager DF. Limits on optimizing ocular drug delivery Journal of Pharmaceutical Sciences 80; 1991: 50-53.