nanoparticles

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Presentation Transcript

Slide 1: 

NANOPARTICLES SEVEN HILLS COLLEGE OF PHARMACY VENKATRAMAPURAM, TIRUPATI SUBMITED BY: SUBHASHIS DEBNATH, M.PHARMACY,(Ph.D) And G. RADHIKA

Slide 2: 

Introduction CONVENTIONAL DOSAGE FORM SMALL AMOUNT OF ADMINISTERED DOSE REACHES TO THE TERGATED SITE Therefore developing a drug delivery system that optimizes the pharmaceutical action of a drug while reducing its toxic side effects in vivo is a challenging task

DEFINITION : 

DEFINITION Solid colloidal particles Diameter 1-1000nm Macromolecular materials Used therapeutically as adjuvant in vaccines

ADVANTAGES : 

ADVANTAGES NANOPARTICLES PARTICLE SIZE CAN EASILY MANIPULATED CONTROL AND SUSTAIN RELEASE SITE SPECIFIC TARGETING VARIOUS ROUTES OF ADMINISTRATION BETTER DRUG UTILIZATION AND LESS SIDE EFFECT

TYPES OF NANOPARTICLES : 

TYPES OF NANOPARTICLES NANOPARTICLES NANOSPHERES NANOCAPSULES

POLYMERS USED IN PREPARATION OF NANOPARTICLES : 

POLYMERS USED IN PREPARATION OF NANOPARTICLES POLYMERS NATURAL HYDROPHILIC SYNTHETIC HYDROPHOBIC Eg: proteins Eg: polyesters Polysacchrides Polycyanoacylates

PREPARATION OF NANOPARTICLES : 

PREPARATION OF NANOPARTICLES Ionic Gelation Emulsion cross linking method Nano precipitation Coaceravation Spray drying Salting out method Emulsion droplet method Reverse micellar method Sieving method Poly electrolyte complex

IONIC GELATION : 

IONIC GELATION

EMULSION CROSS LINKING METHOD : 

EMULSION CROSS LINKING METHOD

COACERAVATION : 

COACERAVATION

PHYSICOCHEMICAL CHARACTERISTICS : 

PHYSICOCHEMICAL CHARACTERISTICS

DRUG LOADING : 

DRUG LOADING Incorporating at the time Adsorbing the drug after of nano particle production formation of nano particle by incubating the carrier DRUG LOADING INCORPORATION INCUBATION

DRUG RELEASE : 

DRUG RELEASE

DISTRIBUTION OF NANO PARTICLES : 

DISTRIBUTION OF NANO PARTICLES NANO PARTICLES INTRAVENOUS SUBCUTANEOUS PERORAL OPTHALMIC

THERAPEUTICAL APPLICATIONS : 

THERAPEUTICAL APPLICATIONS

CONCLUSION : 

CONCLUSION Formulation of Nano particles was found to be easier and simpler, to produce stable nano particles with low distribution. It was found to have better targeting to RES organs, hence it may represent as a new alternative, natural and cheaper carrier in therapy for reduction in dose and thereby dose related systemic toxicities, in turn it may reduce the cost of therapy.

Slide 17: 

THANK YOU