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ANAYTICAL STUDY OF SILA TALAKA RAS AND IT'S CLINICAL EFFICACY IN TAMAKA-SWASA :

ANAYTICAL STUDY OF SILA TALAKA RAS AND IT'S CLINICAL EFFICACY IN TAMAKA-SWASA Dr. M. Srinivas Naik Dr.Ajay V.Nagula ( P.G.Scholar ) Dr.N.R.S.Govt . Ayurvedic College , Vijayawada

INTRODUCTION :

INTRODUCTION -Word itself indicate that Hartala and Manahsilla are chief ingredient drugs. -It is prepared in Valuka Yantra . -It is first mentioned in 'Rasa Ratnakara ' ,written by Nitynanda Siddha in for 1day. Then Valuka Pachana should be done for 2 Yamas . Then add equal quantity of Trikatu Churna and Nirgundi Mula Churna seperately . -The drug should be administered in the dose of 1 masha,It acts as swasa,kasahara -After him ;many books mentioned this drug with the same process but with some changes . 13th century A.D. are to be triturated with Gokshura Swarasa and Vasa Swarasa each -In that gives as 1 part of Sodhita Hartala and 4 part of Sodhita Manahsilla

METHOD OF PREPARATION OF DRUG :

METHOD OF PREPARATION OF DRUG Preparation of Sila-talaka ras is divided into 3 phases – 1. Pre-heating Phase – a) Collection and identification of raw materials :- Sr.no . Material Rasa satsra parameters adopted Modern parameter adopted 1 . Haratala Golden yellow in colour; Layed ; Lustrus AAS ; ICPOES 2 . Manahsila Devoid of stones ; Red lotus like colour ; Heavy in weight ; Lustrus AAS; ICPOES

B)Sodhana of Raw Material:- :

B) Sodhana of Raw Material:- Sr . no . Material Ref . Yantra Process Required Material Material Taken Material Obteined 1. Haratala R.T. 11 / 19 Dola yantra Swedana for 6 hours Kushmanda swarasa ; Choornodaka 260 gms 250gms 2. Manahsila R.T. 11/ 114 Khalwa Yantra Bhavana for 7 times Ardraka Swarasa 1 kg 1kg 60gms

C) Bhavana :- :

C) Bhavana :- -Before this ,250 gms hartala and 1kg manahsila are mixed throughly for 2 hours. 1) Gokshura Swarasa :- 500 ml for 1 day . 2) Vasa Swarasa :- 700 ml for 1 day . D) Preparation of Chakrikas :- -Mixture is added with pure water and chakrikas are made . -Become dry and hard with one hour .

E) Fixing Of Sarava In Valuka Yantra :-:

E) Fixing Of Sarava In Valuka Yantra :- -Dried chakrikas are kept in sarava and another sarava kept on first one in upside down manner. - Sandhibandhna is done and for drying after that fixed on Valuka Yantra . 2. Heating Phase :- -Since there is no clear discription of preparation method Sila Talaka Ras firstly done in Kupi pakwa process but it is inconvinient . -On advice of Dr.P.H.C . Murthy preparation of medicine is done in another method i.e. doing Valuka Yantra Pachana .

Slide 7:

Hours Temprature At starting 34˙c At the end of 1 st hour 105˙c At the end of 2 nd hour 148˙c At the end of 3 rd hour 205˙c At the end of 4 th hour 230˙c At the end of 5 th hour 255˙c At the end of 6 th hour 285˙c -Heating phase takes 6 hours only . - Before heating taken mixture is 100gm and after comletion obteined drug is 80 gms .

Slide 8:

3 . Post heating phase :- Test Sila Talaka Ras 1 Sila Talaka Ras 2 Sila Talaka Ras 3 Loss of Drying 3.2% 2.4% 2.0% Water Soluble Extract NLT-8.5% NLT-9.8% NLT-11.2% Ethanol Soluble Extract NLT-14.2% NLT-14.53% NLT-15.68 % a) Mixing of Trikatu and Nirgundi Mula to obtained product . b) Making as tablets :- made in quantity of 250 mg . c) Test and Analysis of prepared medicine :- A) Physio -chemical Analysis :- NLT :- Not Less Than ANALYTICAL STUDY :-

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Sr.no . Solvent Sila Talaka Ras 1 Sila Talaka Ras 2 Sila Talaka Ras 3 1. Inwater Slightly Soluble Slightly Soluble Slightly Soluble 2. Methanol Insoluble Insoluble Insoluble 3. Toluene Insoluble Insoluble Insoluble 4. Chloroform Slightly Soluble Slightly soluble Slightly Soluble 5. Ethyl Alcohol Slightly Soluble Slightly Soluble Slightly Soluble 6. CCl4 Insoluble Insoluble Insoluble 7. HCl Insoluble Insoluble Insoluble C) X-RD :- - Gives % of major element of the compound and also crystal structure - Realgar – 42.07% ; Arsenic Oxide – 42.07% - Presence of un- dectable compound is observed B) Solubility Test :-

Slide 10:

Element Asodhita Haratala Sodhita Haratala Asodhita Manahsila Sodhita Manahsila As (ppm) 46.60 44.81 48.31 54.34 Se Nil Nil 0.01 0.01 Sn 0.06 Nil 0.06 Nil Cd 0.03 0.03 0.031 0.034 B Nil Nil Nil Nil Mn Nil Nil 0.002 0.002 Mg Nil 0.01 0.008 0.044 D) HPTLC :- - Preliminary quantitative analysis which shows the number of E) ICP-OES components presents in the sample accurately and precisely . - On the basis of mild variation in Rf values , that can acceptable in this drug and it indicates that purity of drugs .

Slide 11:

Element Sample 1 Sample 2 Sample 3 As( ppm ) 12.02 14.20 16.11 Sn Nil Nil Nil Mg 0.23 0.15 0.14 Cd 0.0045 0.0056 0.006 Al Nil Nil Nil Ca 0.96 0.86 0.88 Se Nil Nil Nil Mn Nil Nil Nil F ) AA S - -To measure the concentration of element ; Cu , Fe , K ,Zn , Pb , & Na G) E-DAX - elements are present. Elements like As ,Mg , Cd ,Ca is present.

CLINICAL STUDY-: :

CLINICAL STUDY- : ELECTION OF PATIENTS-: A) INCLUSION CRITERIA-: B) EXCLUSIVE CRITERIA-: 1) Age between 12-70 yrs irrespective 1)Cardiac complaints Of sex ,religion, and caste. 2)Endocrine disorder :- D.M.; 2)Difficulty in breathing thyroid hormone diseases 3)Paroxysm of attack of dysponea 3)Other respiratory disorder 4)Wheezing sound P neumo thorax; P yo thorax 5)No/difficult expectoration Malignancy 6)Duration of illness with in 15 yrs 4)H/O Liver or R enal D isorder Aims & objectives- : This clinical trail has been designed to 1)study the etio -pathogenesis of disease tamaka swasa 2)T0 evaluate the efficacy of sila – talaka ras in tamaka swasa .

SELECTION OF DRUG,DOSE,DURATION :

SELECTION OF DRUG,DOSE,DURATION DIAGNOSTIC CRITERIA-: 1)Classical sign& symptom 2) Variability in peak expiratory flow rate during 24 hrs 1)Mode of administration-: oral. 2)Time of administration-:1 tab in morning ;evening &night 3) Anupana -: Honey 4)Dose-:1 TID (250mg each) 5)Period-:30 days 6)Result assessment-:every 7 days 7)Method of study-:single blind method

PARAMETERS FOR ASSESMENT-: :

PARAMETERS FOR ASSESMENT-: 1)SUBJECTIVE PARAMETER-: 2)OBJECTIVE PRAMETER-: b) Hb ; E.S.R; Neutrophil ; c) Eosinophilia h) Ronchi e) Kapha nistivanam (expectoration of sputum) f) Orthopnoea g) Wheezing d) Kasa (cough) c) Swasakrichrrata (difficult brething ) b) Duration of attack a) Pulmonary function test a) Frequency of swasa vega

Slide 15:

Sr:no Symptom n B.T A.T % OF RELIEF S.D S.E T p 1 Frequency of swasa vega 34 3.6 1.7 52.77 1.59 0.5 3.8 <0.01 2 Duration of swasa vega 34 2.5 1.2 52 1.05 0.33 3.87 <0.01 3 Dysponea 34 2.15 1.23 42.71 0.49 0.13 6.71 <0.001 4 Kasa 34 2.05 1 51.51 0.64 0.17 6.04 <0.001 5 Kapha nishtivana 34 2.01 0.8 61.90 0.82 0.26 4.98 <0.001 6 Asino labhate sowkhyam 34 2.1 0.8 61.90 0.82 0.26 4.98 <0.01 7 Sleshma vimokshathe sowkhyam 34 2 1 50 1.26 0.51 1.98 >0.5 8 Wheezing 34 3.3 0.9 66.66 1.34 0.42 5.61 <0.001 9 Ronchi 34 2.8 0.8 67.78 1.44 0.45 4.14 <0.1 10 P.E.F.R. 15 106.2 155 29.32 22.00 9.48 2.26 <0.01 11 Hb 13.08 12.02 7.79 0.91 0.28 3.04 >0.5 12 E.S.R 16 15.8 0.2 7.48 2.38 0.08 >0.5 13 N 56.5 54.2 5.48 10.33 3.26 0.94 >0.5 14 L 35.6 34.8 7.3 10.13 3.20 0.62 >0.5 15 Absolute eosinophile count 34 570.4 424.9 25.57 514.9 143.04 1.02 >0.5

Slide 16:

Sr.no . Effects No. of Patients % 1. No improvement 3 8.82 2. Mild improvement 9 26.47 3. Moderate improvement 16 38.23 4. Marked improvement 7 20.58 5. Complete improvement 2 5.88 OBSERVATION & RESULT-: In present study of 45 patient of tamaka swasa are registered of which 34 patients completed the course of treatment,11 paients left the treatment OVER ALL EFFECT OF THERAPY-:

CONCLUSION :-:

CONCLUSION :- -It is concluded that analytically there is less amount As is present in this drug . Tamaka Swasa . - So Sila Talaka Ras is safe and effective drug for treatment . - Clinically it is evaluated that it effective in 92% of patient of

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