Pharmaceutical aerosols

PowerPoint Presentation: 

1 Srikanth Asst prof Jpnes Mahabub Nagar Pharmaceutical aerosols ; A pharmaceutical Aerosol is defined as'' a system that depends on the power of a compressed or liqueified gas to expel the contents from the container. ''OR Prsessurised dosage form,containing one or more active ingredients,which upon actuation emit a fine dispersion of liquid and solid materials is gaseous medium. Aerosols are also known as ''Pressurised packages.'' these aerosols are ment for topical,systemic and oral adminsration.

PowerPoint Presentation: 

2 Components of Aerosol package; I.Propellant; II.Container; III.Valve and actuator; IV.Product concentrate; Advantages; 1.A dose can be removed without contamination of remaining materials. 2.The medication can be delivered directly to the affected area in a desired form.sucha s spray,stream,quick-breaking foam or stable form. 3.Irratation produced bt mechanical application of topical medication is reduced or eliminated. 4.Ease,convenience of application of medication in athin layer.

PowerPoint Presentation: 

3 I.Propellants; Propellant is responsible for developing the proper pressure within the container,and it expels the product when the valve is opened and aids in the atomization or foam production of the product. Types of propellants; I.Liquid gas propellan t. a.Chloroflurocarbons; 1.Trichloromonofluromethane or propellant11. 2.Dichlorofluromethane or propellant 12. 3.Dichlorotetra fluroethane or propellant 114. b.Hydrocarbons; 1.Butane. 2.Isobutane. 3.Propane.

PowerPoint Presentation: 

4 IICompressed gas propellant; 1.Nitrogen. 2.Oxygen. 3.Carbon-di-oxide.

PowerPoint Presentation: 

5 II.Container; Various materials are used in the manufacture fof aerosols.the container used in formulation should withstand pressure as high as 140 to 180 psig (Pounds per square inch gauze) at 130oF Types of materials used; I Metal; II Glass; I Metal; 1.Tin plate steel; a.Side seam;(three piece) b.Two piece or Drawn. c. Tin-free steel. 2.Aluminium; a.Two piece. b.One piece (extruded or Drawn)

PowerPoint Presentation: 

6 3.Stainless; II Glass; 1.Uncoated glass. 2.Plastic coated glass.

PowerPoint Presentation: 

7 III.Valves and actuator; Valves are imporatant for aerosols containers as they help in expelling the contents from the container.The performance of the aerosol depends on the type of formulation and valve.They regulate the flow of the product and discharge the desiered amount.The valve helps the loss of product when the container is not in use. With the help of actuator present on the valve,the foam product present in the container can dispensed in the form of spray or wet stream.the type of product formed i.e,foam,spray or wet stream depends on tha proper selection of propellant during formulation.

PowerPoint Presentation: 

8 Continuous spray valve; 1.Ferrule or mouning cup; 2.Valve body or Housing; 3.Stem; 4.Gasket; 5.Spring; 6.Dip tube;

PowerPoint Presentation: 

9 Metred valves; Meter valves are applicable to the dispensing of potent medication. Actuators;(Button); These are many different types of actuators; 1.Spray actuators. 2.Foam ''. 3.Solid stream ''. 4.Special applications. Formulation of pharmaceutical aerosols; An aerosols formulation consistes of 2 essential components; 1.Product concentrate . 2.Propellant.

PowerPoint Presentation: 

10 Types of systems; 1.Solution system or Two phase system. 2.Three phase system or water based system. 3.Suspension or dispersion system. 4.Foam system. a.Aqueous stable foams; b.Non-aqueous stable foams; c.Quick breaking foams; d.Thermal foams; 5.Intranasal system.

PowerPoint Presentation: 

11 Selection of componets; 1.Propellant; 2.Containers; 3.Chemical Reactions; 4.Other containers; Stability Testing of Pharmaceutical aerosols; 1.Concentrate and Propellants; 2.Containers; 3.Valves;

PowerPoint Presentation: 

12 Manufacture of Pharmaceutical Aerosols; 1.Pressure filling apparatus; 2.Cold filling apparatus; 3.Compressed gas filling apparatus;

PowerPoint Presentation: 

13 Large scale equipments; 1.Concentrate filler; 2.Valve placer; 3.Purger and vaccum crimper; 4.Pressure filler; 5.Leak test tank;

PowerPoint Presentation: 

14 Manufacture procedure; Quality control for Pharmaceutical aerosols; 1.Propellants; 2.Valvaes,Actuators,and Dip tubes; 3.Containers; 4.Weught checking; 5.Leak testing; 6.Spray testing;

PowerPoint Presentation: 

15 Evaluation of Pharmaceutical Aerosols; A.Flammability and Combustibility; 1.Flame projection; 2.Flash point; B.Physicochemical charecterstics; 3.Vapour pressure; 4.Density; 5.Moisture; 6.Identification of propellants;

PowerPoint Presentation: 

16 C.Performance; 7.Aerosol valve discharge rate; 8.Spray patterns; 9.Dosage with Metered valves; 10.Net contants; 11.Foam stability; 12.Particle size determination; 13.Leakage; D.Biological testing; 14.Therapeutic activity; 15.Toxicity