PowerPoint Presentation:
Defination of epithelial dysplasia- Dyplasia-Reagon 1958
Mechanism of transformation of epithelium from normal to dysplastic changes:
Mechanism of transformation of epithelium from normal to dysplastic changes
Grading of epithelial dysplasia and its applications: :
Grading of epithelial dysplasia and its applications: 1. Smith and Pindborgs’photographic method (1969) 2. Banoczy and Csiba (1976) 3. WHO (1978) 4. Kramer (1980) 5. Burkhardt and Maerkar (1981) 6. Lumermann H Et al (1995) 7. Neville et al (1995) 8. Speight P M et al (1996) 9. Kuffer and Lombardi (2002) 10. Ljubljana (2003) 11. Brothwell DJ (2003) 12. Binary system (2005)
Cellular changes:
Cellular changes Abnormal variation in nuclear size and shape Abnormal variation in cell size and shape Increased nuclear/cytoplasm Enlarged nuclei and cell Hyperchromatism Increased mitotic figures Increased number and size of nucleoli
Architectural changes:
Architectural changes Loss of cohesion Basal cell hyperplasia Dyskeratosis Bulbous rete pegs Irregular epithelial stratification Keratin pearl within rete pegs Acanthosis
Grading of dysplasia:
Grading of dysplasia Mild Moderate Severe Carcinoma in situ