Xylene: a drugful tool

Xylene: an overview of it's health hazards & preventive measures: 

Journal of oral & maxillofacial pathology- vol14 issue 1, Jan,2010 -reena kandyala, sumanth p &saraswati r(vishnu dental college,bhimavaram,AP, india) Xylene: an overview of it's health hazards & preventive measures

Introduction: 

Introduction § colourless liquid or gas § uses § exposure limits § exposure sorces- soil § smelling mostly begins at 0.08-3.7ppm § taste@0.53-1.8ppm

Toxicity of xylene: 

Toxicity of xylene Default body

Toxicity of xylene: 

Toxicity of xylene Routes Excretion Severity Health effects from both acute & chronic exposure

Nervous system: 

Nervous system concentration Ill effects on nervous system 100-200 ppm Nausea, headache 200-500 ppm Feeling HIGH, dizziness, weakeness , vomiting, ringing in ears 800-1000ppm Giddiness, confusion, clumsiness, loss of balance, ringing in ears >10000 ppm Sleeiness , loss of consciousness, death

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Eyes , nose & throat

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Lungs Liver & kidney

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Blood Gastrointestinal tract

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Musculoskeletal system skin

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Cancer Reproductive system

PREVENTIVE MEASURES: 

PREVENTIVE MEASURES Substitution Local exaust ventilation Proper protective equipment

Substitution: 

Substitution Limonene reagents Aliphatic hydrocarbon mixtures Aromatic hidrocarbon mixtures Mineral oil mixtures

Local exaust ventilation: 

Local exaust ventilation Fan Hood System of ducts Air cleaning device Source of make up air

Proper protective equipment: 

Proper protective equipment

Biological monitoring: 

Biological monitoring

Emergency procedures: 

Emergency procedures Eye exposure Skin exposure Inhalation ingestion

CONCLUSION : 

CONCLUSION Efforts to reduce the health hazards in the histology labs should be made to create a safer working atmosphere by making the histopathology technicians more familiar with the hazards of xylene ,safety measures & emergency procedures The hazards of xylene are well documented ,but the substitutes are not thoroughly evaluated. Less expensive substitutes – sold under trade names without any obvious disclosure of the chemicals of which they are composed. Use of proper personal protective equipment & a descent fume hood MAKE A LAW- to safeguard h/p technicians.

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Thank you.