Stimuli responsive nanomaterials as a dr

Stimuli Responsive Nanomaterials as Drug Carriers : 

Stimuli Responsive Nanomaterials as Drug Carriers By: Sijumon Kunjachan (September 2009) CHE 674: Introduction to Nanoscience and Technology Instructor: Dr. Sri Sivakumar Department of Chemical Engineering, Indian Institute of Technology Kanpur, INDIA

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What are Stimuli responsive polymers? Stimuli-responsive polymers are polymers that respond with dramatic property changes to small changes in their environment*. They are also called “smart polymeric delivery systems” or “Intelligent systems” or “sensitive polymeric systems” Environmental changes could be temperature-, pH-, ionic strength-, light-, electric- and magnetic field-sensitive or a combination of two or more stimuli. They are widely categorized into 3 different types: *TRENDS in Biotechnology Vol.20 No.7 July 2002

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Physical stimuli polymeric nanocarriers* Thermo responsive polymeric systems * Chem. Soc. Rev., 2005, 34, 276–285

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Chemical stimuli polymeric nanocarriers pH responsive polymeric drug delivery system Polyacrylic acid, polymethacrylic acid (PMAA), poly(ethylene imine), poly(L-lysine), and poly(N,N-dimethyl aminoethyl methacrylamide) are typical examples of pH-sensitive polymers

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Biological stimuli responsive polymeric nanocarriers Glucose-responsive polymeric nanoparticulate DDS Blood circulation

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One Step Synthesis of Biotinylated ‘Smart’ Polymers Bontempo, D.; Li, R.C.; Ly, T.; Brubaker, C.E.; Maynard, H.D. Chem. Commun. 2005.

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Commonly used responsive polymers

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A model drug sensing nanomaterial* *Ref: http://macromolecules.case.edu/research_stimuli-responsive.htm

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An application of stimuli responsive nanocarriers for the treatment of cancer VIDEO

Challenges and Limitations : 

Challenges and Limitations Properties of responsive drug delivery device Combination of sensing and delivery Small and easy to administer and remove patient compliance Long-lived, Biocompatible and inexpensive Safe from accidental release, easy to synthesize and sterilize and allow high drug loading Continuous monitoring and allow physician intervention if needed

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Response to stimulus is a basic process of living systems…..!! Thank You