Sjogren Syndrome

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Sjogren’s Syndrome : 

Sjogren’s Syndrome By SIDRA MAQSOOD (DCP) DOW UNIVERSITY OF HEALTH SCIENCES(DUHS)

What is Sjogren’s syndrome? : 

What is Sjogren’s syndrome? Sjogren’s syndrome is a chronic autoimmune disorder characterized by xerostomia (dry mouth), xerophthalmia (dry eyes), and lymphocytic infiltration of the exocrine glands. In Sjogren’s syndrome the body’s defense system turns againist itself and attacks glands that produce moisture.

Slide 3: 

Primary Sjogren’s Syndrome, which comprises dry mouth and dry eyes NOT ASSOCIATED with any connective tissue disease. Secondary Sjogren’s Syndrome, which comprises dry mouth and dry eyes ASSOCIATED with Rheumatoid Arthritis OR any connective tissue disease.

Suspected Causes : 

Suspected Causes The cause of Sjogren’s Syndrome is unknown, however there are some contributing factors: Heredity Viral Infection Hormones

Early Symptoms : 

Early Symptoms Dry eyes Dry mouth Difficulty chewing Dry cough Dry nose Dry throat Dry lungs Fatigue

Late Symptoms : 

Late Symptoms Cavities Difficulty Swallowing Difficulty Chewing Oral Yeast Infections

Oral effects : 

Oral effects Discomfort Difficult with eating or swallowing Disturbed taste sensation Disturbed quality of speech Predisposition to infection

Ocular effects : 

Ocular effects Failure of tear secretion Failure of clearance of foreign particles from the cornea and conjunctiva Gritty sensation in the eyes and inflammation (keratoconjectivitis sicca) Risk of impairment or loss of sight.

Sjogren’s is Systemic : 

Sjogren’s is Systemic All instances of Sjogren’s Syndrome are systemic, affecting the entire body. Although the hallmark symptoms of Sjogren’s syndrome are dry eyes and mouth, it can cause dryness of other organs affecting the kidneys, GI tract, vessels, lungs, liver, pancreas, and the CNS. Patients experience debilitating fatigue and joint pain

Sjögren's Syndrome : 

Sjögren's Syndrome

Lab Work : 

Lab Work Schirmer test/Slit-lamp exam measures dryness of eyes Erythrocyte Sedimentation rate (ESR) Complete Blood Count Urine Test

Schirmer test : 

Schirmer test

Diagnosis : 

Diagnosis Sjogren’s syndrome is diagnosed by blood tests, a decrease in tear and saliva production, salivary glands, and lip biopsy. Early diagnosis and a maintenance of dental and eye care is extremely important. Rheumatologists primarily have the responsibility of diagnosing and managing Sjogren’s Syndrome.

Prognosis of the disease : 

Prognosis of the disease Ocular dryness can lead to chronic keratoconjunctivitis and corneal ulcers. Oral dryness leads to cavities, fissures, canidal infections and difficulty speaking and swallowing food. This disease process rarely shortens a patient’s lifespan.

Facts about the disease : 

Facts about the disease It occurs 10 times more often in women than in men. Onset can occur at any age, but usually between 45 and 55 years of age.

Treatment : 

Treatment Depends on symptoms. Artificial tears, eye ointments Saliva substitutes Frequent dental visits

Treatment of xerophthalmia : 

Treatment of xerophthalmia General measures and replacement therapy Protective bicarbonate buffer solutions Stimulators of tear production Local : Cyclosporine A Systemic: Pilocarpine, Cimeviline Operative procedures

Treatment of Xerostomia : 

Treatment of Xerostomia Oral hygiene to prevent DENTAL CARIES Early diagnosis and treatment of oral Candidiasis Saliva substitutes Systemic stimulation of glandular secretions

Slide 20: 

Dryness of the eyes is treated with artificial tears such as METHYL CELLULOSE solution. In dental patients, sweet-eating should be prohibited.

Slide 21: 

Thanks Sidra Maqsood