logging in or signing up penetration enhancers shiva029 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 252 Category: Science & Tech.. License: All Rights Reserved Like it (0) Dislike it (0) Added: June 17, 2011 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: thokesagar (1 month(s) ago) will u plz send me ur ppt my id thokesagar7@gmail.com or thokesagar@yahoo.com Saving..... Post Reply Close Saving..... Edit Comment Close By: yustine (7 month(s) ago) can i have your presentation? pleaase send it to my_pinkrose@yahoo.com Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Slide 1: PENETRATION ENHANCERS Presentation By Shivraj P. Jadhav II sem. M. Pharm (Pharmaceutics) Amrutvahini college of pharmacy, Sangamner. 1Slide 2: 2INTRODUCTION: INTRODUCTION 3THE SKIN: Weight of skin: 8 pounds Surface Area: 20,000 cm 2 Three layers: Epidermis (Stratum corneum) Dermis Subcutaneous layer THE SKIN 4 TRANSPORT ACROSS SKIN : TRANSPORT ACROSS SKIN 5MAIN BARRIERS: MAIN BARRIERS 6factors affecting absorption: factors affecting absorption 7PENETRATION ENHANCEMENT TECHNIQUES: PENETRATION ENHANCEMENT TECHNIQUES 8CLASSIFIACTION: CLASSIFIACTION 9Chemical Enhancers: Chemical Enhancers 10IDEAL PROPERTIES: IDEAL PROPERTIES 11DIFFERENT CHEMICAL ENHANCERS: DIFFERENT CHEMICAL ENHANCERS Water Sulfoxide and similar chemicals Azons Pyrrolidons Fatty acids Alcohols, fatty alcohols ,glycols Surfactant Urea Essential oils, terpens, terpenoids 12WATER: WATER 13SULPHOXIDE AND SIMILAR COMPOUND: SULPHOXIDE AND SIMILAR COMPOUND 14AZONES: AZONES 15PYRROLIDONES: PYRROLIDONES 16ALCOHOLS, FATTY ALCOHOLS,GLYCOLS: ALCOHOLS, FATTY ALCOHOLS,GLYCOLS 17SURFACTANTS: SURFACTANTS 18UREA: UREA 19PRODRUG: PRODRUG 20Slide 21: Occlusion can enhance the penetration of drugs through the stratum corneum by increased hydration. Due to hydration pore size will be increases . VESICLES AND CARRIER SYSTEMS Ultra deformable carrier system 21Slide 22: Structure based Electric based Velocity based Microneedles Iontophoresis Electrphoresis Phonophoresis Jet injectors 22ELECTRIC BASED: ELECTRIC BASED Iontophoresis 23ELECTRIC BASED: ELECTRIC BASED Electroporation 24ELECTRIC BASED: ELECTRIC BASED Phonophoresis/ Sonophoresis 25STUCTURE BASED: STUCTURE BASED Microneedle approach 26VELOCITTY BASED: VELOCITTY BASED Jet injectors 27CONCLUDING REMARKS: CONCLUDING REMARKS The ultimate goal of penetration enhancer is to assure that the compounds are delivered preferably at specific rate to remain at topical site or to reach the systemic circulation. The customization drug vehicles and enhancers may be most promising future direction for transdermal enhancement and drug delivery. 28REFERENCES: REFERENCES Heather A.E. Benson, transdermal drug delivery: penetration enhancement techniques, current drug delivery, 2005, 2, 23-33. Shradha R. Baheti, kamlesh J. Wadher, Milind J. Umekar, A recent approach towards transdermal drug delivery by physical and chemical techniques ,Internationale pharmaceutica sciencia, jan-march 2011, vol. 1, issue 1,42-53. Dinesh Dhamecha, Amita Rathi , Maria Saifee , drug vehicle based approaches of penetration enhancement, international journal of pharmacy and pharmaceutical sciences, vol. 1, issue 1, july-sep. 2009, 24-46. H. Trommer, R.H.H. Neubert, Overcoming the Stratum Corneum: The Modulation of Skin Penetration A Review, Skin Pharmacoloy and Physiology, 2006;19:106–121. 29Slide 30: THANK YOU !!! 30Slide 31: 31 You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
penetration enhancers shiva029 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 252 Category: Science & Tech.. License: All Rights Reserved Like it (0) Dislike it (0) Added: June 17, 2011 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: thokesagar (1 month(s) ago) will u plz send me ur ppt my id thokesagar7@gmail.com or thokesagar@yahoo.com Saving..... Post Reply Close Saving..... Edit Comment Close By: yustine (7 month(s) ago) can i have your presentation? pleaase send it to my_pinkrose@yahoo.com Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Slide 1: PENETRATION ENHANCERS Presentation By Shivraj P. Jadhav II sem. M. Pharm (Pharmaceutics) Amrutvahini college of pharmacy, Sangamner. 1Slide 2: 2INTRODUCTION: INTRODUCTION 3THE SKIN: Weight of skin: 8 pounds Surface Area: 20,000 cm 2 Three layers: Epidermis (Stratum corneum) Dermis Subcutaneous layer THE SKIN 4 TRANSPORT ACROSS SKIN : TRANSPORT ACROSS SKIN 5MAIN BARRIERS: MAIN BARRIERS 6factors affecting absorption: factors affecting absorption 7PENETRATION ENHANCEMENT TECHNIQUES: PENETRATION ENHANCEMENT TECHNIQUES 8CLASSIFIACTION: CLASSIFIACTION 9Chemical Enhancers: Chemical Enhancers 10IDEAL PROPERTIES: IDEAL PROPERTIES 11DIFFERENT CHEMICAL ENHANCERS: DIFFERENT CHEMICAL ENHANCERS Water Sulfoxide and similar chemicals Azons Pyrrolidons Fatty acids Alcohols, fatty alcohols ,glycols Surfactant Urea Essential oils, terpens, terpenoids 12WATER: WATER 13SULPHOXIDE AND SIMILAR COMPOUND: SULPHOXIDE AND SIMILAR COMPOUND 14AZONES: AZONES 15PYRROLIDONES: PYRROLIDONES 16ALCOHOLS, FATTY ALCOHOLS,GLYCOLS: ALCOHOLS, FATTY ALCOHOLS,GLYCOLS 17SURFACTANTS: SURFACTANTS 18UREA: UREA 19PRODRUG: PRODRUG 20Slide 21: Occlusion can enhance the penetration of drugs through the stratum corneum by increased hydration. Due to hydration pore size will be increases . VESICLES AND CARRIER SYSTEMS Ultra deformable carrier system 21Slide 22: Structure based Electric based Velocity based Microneedles Iontophoresis Electrphoresis Phonophoresis Jet injectors 22ELECTRIC BASED: ELECTRIC BASED Iontophoresis 23ELECTRIC BASED: ELECTRIC BASED Electroporation 24ELECTRIC BASED: ELECTRIC BASED Phonophoresis/ Sonophoresis 25STUCTURE BASED: STUCTURE BASED Microneedle approach 26VELOCITTY BASED: VELOCITTY BASED Jet injectors 27CONCLUDING REMARKS: CONCLUDING REMARKS The ultimate goal of penetration enhancer is to assure that the compounds are delivered preferably at specific rate to remain at topical site or to reach the systemic circulation. The customization drug vehicles and enhancers may be most promising future direction for transdermal enhancement and drug delivery. 28REFERENCES: REFERENCES Heather A.E. Benson, transdermal drug delivery: penetration enhancement techniques, current drug delivery, 2005, 2, 23-33. Shradha R. Baheti, kamlesh J. Wadher, Milind J. Umekar, A recent approach towards transdermal drug delivery by physical and chemical techniques ,Internationale pharmaceutica sciencia, jan-march 2011, vol. 1, issue 1,42-53. Dinesh Dhamecha, Amita Rathi , Maria Saifee , drug vehicle based approaches of penetration enhancement, international journal of pharmacy and pharmaceutical sciences, vol. 1, issue 1, july-sep. 2009, 24-46. H. Trommer, R.H.H. Neubert, Overcoming the Stratum Corneum: The Modulation of Skin Penetration A Review, Skin Pharmacoloy and Physiology, 2006;19:106–121. 29Slide 30: THANK YOU !!! 30Slide 31: 31