novel drug delivery system

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By: radhakrishnagoli (101 month(s) ago)

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NOVEL DRUG DELIVERY SYSTEM (NDDS):

NOVEL DRUG DELIVERY SYSTEM (NDDS) K.Senthil Kumar. M.Pharm Asst. professor Department of Pharmaceutics QIS college of pharmacy Ongole ,A.P-India 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 1

INTRODUCTION:

For many years the conventional dosage forms are used to treat the acute or chronic disease. Even today these conventional dosage form as primary pharmaceutical product in market. Eg. Tablet Capsule Creams Paste Suppositories Emulsion etc…… INTRODUCTION 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 2

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Why do we need novel drug delivery system ? 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 3

Why do we need NDDS ?:

These conventional dosage form provide drug release for immediately and it causes fluctuation of drug level in blood. Therefore to maintain the drug concentration within the therapeutically effective range need novel drug delivery system .(NDDS) Why do we need NDDS ? 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 4

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Novel drug delivery system (NDDS) is a system for delivery of drug other than conventional drug delivery system. Novel drug delivery companies have existed since the late 1960s to enhanced oral drug delivery Recently several techniques are developed to controlled or sustained and target the drug release for particular site . There are great opportunities for companies investing in R&D for new, improved drug delivery system, allowing for improved therapeutic absorption and efficacy in patients 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 5

Advantages of NDDS ? :

Decreased  in dosing frequency Reduced rate of rise of drug concentration in blood. Sustained & Consistent blood level with in the therapeutic window. Enhanced bioavailability To achieve a targeted drug release Reduced side effects Improved patient compliance Advantages of NDDS ? 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 6

Plasma concentration VS time profile :

Plasma concentration VS time profile 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 7

SUSTAINED VS CONTROLLED :

SR-Release of the intial dose further prolonged release.It is also called as extended release (ER), Delayed release (DR), prolonged release , time release drug release or pulsatile drug release. The drug release follows first order kinetics CR- Relase of the drug in controlled release for long period . The drug release follows ZERO order kinetics . SUSTAINED VS CONTROLLED 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 8

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SRF’s describes the slow release of a drug substance from a dosage form to maintain therapeutic response for extended period (8-12hrs)of time. Time depends on the dosage form. In oral form it is in hours, and in parenteral’s it is in days and months. Ex: Aspirin SR, Dextrim SR. Controlled release dosage form: In this the rate or speed at which the drug is released is controlled. Ex: Adalat CR (Nifidipine), Dynacirc CR (Isradipine.) 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 9

TERMINOGIES FOR SRF:

Extended release (ER / XR /XL) Modified release (MR) Pulsatile release Time drug release or choronotherapy Delayed release(DR) Continuous release Sustained action (SA) Sometimes it is called as controlled release . But all controlled release are not SR. TERMINOGIES FOR SRF 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 10

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole Global drug delivery market by administration mode Oral 53% Inhalation 32% Transdermal 8% Injectable/Implant 3% Ocular 2% Nasal 2% 11

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Drug Delivery Systems Oral Inject-able Mucosal Trans-dermal Ocular Vaginal/Anal Needle Needle-less Nasal Buccal Pulmo-nary Active Passive Topical 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 12

Novel drug Delivery Systems:

Novel drug Delivery Systems 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 13

DRUG DELIVERY:

Drug delivery is the method or process of administering pharmaceutical compound to achieve a therapeutic effect in humans or animals . Most common methods of delivery include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal ( nasal , buccal / sublingual , vaginal , ocular and rectal ) and inhalation routes DRUG DELIVERY 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 14

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Many medications such as peptide and protein , antibody , vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective protein and peptide drugs have to be delivered by injection . 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 15

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole 16

TARGETED DRUG DELIVERY (TDDS):

Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and in which the drug is released over a period of time in a controlled manner TARGETED DRUG DELIVERY (TDDS) 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 17

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole 18

List of drug carriers in NDDS :

Nanosomes Liposomes Niosomes Proniosomes vesicular drug delivery system Cubisomes Aquasomes Pharmacosomes Nanoparticle Nanosphere Microsphere Microparticle Transferosomes Microemulsion Nanosuspension Dendrimers Micellls Dendrosomes , List of drug carriers in NDDS 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 19

NOVEL CARRIERS:

NOVEL CARRIERS 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 20

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Red Blood Cells(RBC ) The normal erythrocyte is flexible , elastic a& biconcave shape with thickness near 2.2um . it consist of red blood cells include water (63%), lipids( 0.5%), , glucose (0.8% ), minerals (0.7%),non hemoglobin protein (0.9%), methehemoglobin (0.5%) and hemoglobin (33.67%) The primary function of the erythrocyte is transport of oxygen and co2. The term carrier RBC was first introduced in 1979. RESEALED ERTHYROCYTES 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 21

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole 22

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It should be biocompatible It is biodegradable in nature The large amount of drug can be encapsulated in small volume of cells It can be target to disease tissue or organ. 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 23

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Blood is withdrawn from cardiac puncture ( in case of small animals ) and through veins ( in large animals ) in to syringe containing a drop of anticoagulant .the whole blood centrifuged at 2500 rpm for 5 min. the serum and buffy coats are carefully removed and packed cells washed 3 times with phosphate buffer saline (PBS , Ph 7.4) The washed erthyrocytes are diluted with PBS and stored at 4 0 c until used. 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 24

Microsphere and Microcapsule :

Microsphere and Microcapsule 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 25

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole 26

SEM Photo of microsphere:

SEM Photo of microsphere 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 27

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole 28

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole 29

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NIOSOMES 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 30

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Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 31

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole 32

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NANO CARRIERS 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 33

TRANSDERMAL DRUG DELIVERY SYSTEM:

TRANSDERMAL DRUG DELIVERY SYSTEM 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 34

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4/18/2011 k.senthil , Asst.prof, qiscp, ongole 35

ORAL OSMOTIC DRUG DELIVERY SYSTEM:

ORAL OSMOTIC DRUG DELIVERY SYSTEM 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 36

GASTRO RETENTIVE DRUG DELIVERY SYSTEM :

GASTRO RETENTIVE DRUG DELIVERY SYSTEM 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 37

OCULAR DRUG DELIVERY SYSTEM:

OCULAR DRUG DELIVERY SYSTEM 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 38

BUCCAL DRUG DELIVERY SYSTEM:

BUCCAL DRUG DELIVERY SYSTEM 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 39

COLON DRUG DELIVERY SYSTEM:

COLON DRUG DELIVERY SYSTEM 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 40

PULSINCAP DELIVERY SYSTEM:

PULSINCAP DELIVERY SYSTEM 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 41

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Controlled / sustained drug delivery oral parentral Mucoadhesive / bioadhesive drug delivery Transdermal drug delivery Nasal drug delivery Targeted drug delivery Ocular drug delivery Novel protein & peptide drug delivery Novel design of drug delivery 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 42

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Dermatology Inflammatory/ Immune-related Oncology/ Cancer Respiratory Cardiovascular/ Blood Disorder Musculoskeletal Infectious Disease Microbial/Viral Neurological/ Pyschotherapeutic Ophthalmic Metabolic Gastrointestinal Important DRUG Targets Focused Areas of Research 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 43

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THANKYOU 4/18/2011 k.senthil , Asst.prof, qiscp, ongole 44

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