nanotechnology

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By: kxswami (27 month(s) ago)

Very Nice presentation. I am preparing for a presentation on TiO2 nanoparticles and I could use some of your introduction slides in my presentation. Could you please send your presentaion at kxswami@yahoo.com. Thanks

By: engrami (28 month(s) ago)

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By: karthik122 (39 month(s) ago)

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By: karthik122 (39 month(s) ago)

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Presentation Transcript

Nanotechnology : 

Nanotechnology Nano size: Generally 1-100 nm The European Science Foundation definition Nanoscale was seen to range from 1 to 1000 nm

Particle size classification : 

Particle size classification 1 nm Chemical drug 5 nm Protein 10 nm DNA 20-50 nm Blood vessel pore 50 nm Carbon nanotube 100-500 nm Liposome nanoparticle 1000 nm (1 µm) bacteria 10 µm Cell 50 µm Human hair

Cell membrane pore : 

Cell membrane pore A side view of a pore (blue dots) in the water-channel protein AQP1, which pierces the cell membrane. Cell exterior is at top, interior at bottom. The pore is about 2.8 angstroms across at its narrowest.

Advantages of nanoparticles : 

Advantages of nanoparticles Advantage of nanoparticles - To deliver more effectively: Enhance amount permeate at favorable site, sustain release of actives, increase mucoadhesive (liposome, neosome, nanoparticle, microemulsion, nanoemulsion) Nano-powder (Zno, TiO2 etc) Carbon nanotube

Titanium dioxide nano powder : 

Titanium dioxide nano powder

Toxicology of nanoparticles : 

Toxicology of nanoparticles Size Surface area Surface chemistry Solubility Shape Material type 1) biodegradable 2) Non-biodegradable * Depend on phagocytic clearance

Exposure routes : 

Exposure routes

Phagocytosis : 

Phagocytosis Most Dangerous 2 1 3

Limited Experimental toxicology of manufactured nanomaterials reported to date : 

Limited Experimental toxicology of manufactured nanomaterials reported to date Fullerenes Carbon nanotube Metal oxide nanoparticles (ZnO, TiO2)

Slide 13: 

Eight allotropes of carbon: a) Diamond, b) Graphite, c) Lonsdaleite, d) C60 (Buckminsterfullerene or buckyball), e) C540, f) C70, g) Amorphous carbon, and h) single-walled carbon nanotube or buckytube.

Research work in nanoparticles toxicology : 

Research work in nanoparticles toxicology Use carbon single wall carbon nanotube (SWCNT) as model SWCT do not induce cell damage but stimulate fibroblast proliferation and collagen synthesis→ Lung Fibrosis Small well disperse SWCNT penetrate lung tissue more efficiently than agglomeration SWCT induce angiogenesis

Nanomaterialization of Chitin-chitosan: Approaches and potential applications : 

Nanomaterialization of Chitin-chitosan: Approaches and potential applications Nanomaterials: the materials which exhibit the special properties due to the function in nanometer range

Formation of nanomaterials : 

Formation of nanomaterials Molecolar Architecture: Building from molecular components, Chemical modification Size reduction: Constructing from large entities, Depolymerization

Chitosan Nanosphere : 

Chitosan Nanosphere Synthesis Organic base system: mPEG grafted phthaloylchitin Water base system: Chitosan-mPEG-CA

Self assembly property : 

Self assembly property

Slide 19: 

PEG

UV-screening Nanocarrier Based on polyvinylalcohol-co-vinylcinnamate : 

UV-screening Nanocarrier Based on polyvinylalcohol-co-vinylcinnamate Chemical modification Amphiphilic polymer: self-assembly: PVA combined UV protective substances